scholarly journals Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis

2020 ◽  
Vol 598 (16) ◽  
pp. 3373-3393 ◽  
Author(s):  
Tiina Petäistö ◽  
David Vicente ◽  
Kari A. Mäkelä ◽  
Mikko A. Finnilä ◽  
Ilkka Miinalainen ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Collagen Xviii ◽  
Hepatic Glucose ◽  
Glucose And Lipid Homeostasis

scholarly journals Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis

2020 ◽  
Vol 598 (16) ◽  
pp. 3329-3330
Author(s):  
Jessica L. Braun ◽  
Mia S. Geromella ◽  
Sophie I. Hamstra
Keyword(s):  
Lipid Homeostasis ◽  
Collagen Xviii ◽  
Hepatic Glucose ◽  
Glucose And Lipid Homeostasis

scholarly journals Soluble Klotho Improves Hepatic Glucose and Lipid Homeostasis in Type 2 Diabetes

2020 ◽  
Vol 18 ◽  
pp. 811-823 ◽  
Author(s):  
Huiying Gu ◽  
Wei Jiang ◽  
Nan You ◽  
Xiaobing Huang ◽  
Yuming Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Homeostasis ◽  
Hepatic Glucose ◽  
Glucose And Lipid Homeostasis

scholarly journals PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis

PLoS Genetics ◽  
2015 ◽  
Vol 11 (10) ◽  
pp. e1005561 ◽  
Author(s):  
Yong-Sheng Cheng ◽  
Oksana Seibert ◽  
Nora Klöting ◽  
Arne Dietrich ◽  
Katrin Straßburger ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Hepatic Glucose ◽  
Glucose And Lipid Homeostasis

scholarly journals Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis

Oncotarget ◽  
2017 ◽  
Vol 8 (53) ◽  
pp. 91362-91378 ◽  
Author(s):  
Xiliang Du ◽  
Yuchen Yang ◽  
Chuang Xu ◽  
Zhicheng Peng ◽  
Min Zhang ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Hepatic Glucose ◽  
Glucose And Lipid Homeostasis

Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway

2021 ◽  
Vol 12 (6) ◽  
pp. 2726-2740
Author(s):  
Dong-Xue Xu ◽  
Xiao-Xuan Guo ◽  
Zhu Zeng ◽  
Yong Wang ◽  
Jing Qiu
Keyword(s):  
Insulin Resistance ◽  
Hepatic Insulin Resistance ◽  
Lipid Homeostasis ◽  
Therapeutic Effects ◽  
Ampk Pathway ◽  
Hepatic Glucose ◽  
Glucose And Lipid Homeostasis

Identification of potential therapeutic effects of puerarin for the prevention of hepatic insulin resistance and steatosis in vivo and in vitro.

scholarly journals Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

Diabetologia ◽  
2013 ◽  
Vol 56 (10) ◽  
pp. 2286-2296 ◽  
Author(s):  
C. Owen ◽  
E. K. Lees ◽  
L. Grant ◽  
D. J. Zimmer ◽  
N. Mody ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Lipid Homeostasis ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Adult Mice ◽  
Glucose And Lipid Homeostasis

205-LB: HGFAC Is a ChREBP-Regulated Hepatokine That Enhances Glucose and Lipid Homeostasis

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 205-LB
Author(s):  
ASHOT SARGSYAN ◽  
LUDIVINE DORIDOT ◽  
SARAH A. HANNOU ◽  
WENXIN TONG ◽  
HARINI SRINIVASAN ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Glucose And Lipid Homeostasis

scholarly journals The Effects of Naphthenic Acids on Tryptophan Metabolism and Peripheral Serotonin Signalling

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A493-A493
Author(s):  
Laiba Jamshed ◽  
Genevieve A Perono ◽  
Shanza Jamshed ◽  
Kim Ann Cheung ◽  
Philippe J Thomas ◽  
...  
Keyword(s):  
Oil Sands ◽  
Naphthenic Acid ◽  
Kynurenine Pathway ◽  
Naphthenic Acids ◽  
Tryptophan Metabolism ◽  
Lipid Homeostasis ◽  
Prostaglandin E ◽  
Serotonin Synthesis ◽  
Active Metabolites ◽  
Glucose And Lipid Homeostasis

Abstract Introduction: Serotonin produced in the periphery has been shown to affect glucose and lipid homeostasis. The availability of the amino acid tryptophan, the precursor of serotonin, affects serotonin availability. In addition, the metabolism of tryptophan via the kynurenine pathway produces physiologically active metabolites which have been shown to be altered under conditions of increased adiposity and dysglycemia. There is now evidence demonstrating some environmental xenobiotics, known to affect glucose and lipid homeostasis, can also alter serotonin production and key components of the kynurenine pathway. Recent evidence suggests that exposure to compounds present in petroleum and wastewaters from oil and gas extraction sites can impact endocrine signaling and result in aberrant lipid accumulation and altered glycemic control. However, whether any of these changes can be causally ascribed to altered serotonin synthesis/signaling or tryptophan metabolism remains unknown. The goal of this study was to determine the effects of exposure to naphthenic acid (NA), a key toxicant found in wastewater from bitumen (thick crude oil present in oil sands deposits) extraction on the enzymes involved in tryptophan metabolism and serotonin production. Methods: McA-RH7777 rat hepatoma cells, were exposed to a technical NA mixture for 48 hours at concentrations within the reported range of NA found in wastewaters from oil extraction. We assessed mRNA expression for key rate-limiting enzymes involved in tryptophan metabolism that lead to either serotonin [Tph1] and/or kynurenine [Ido2 and Tdo2] production, as well as downstream enzymes in the kynurenine pathway [Afmid, Kyat1, Aadat, Kyat3, Kmo, Haao, Acmsd, Qprt]. We also examined the effects of NA on prostaglandin synthesis [Ptgs1, Ptgs2, Ptges] and signalling [Ptger2, Ptger4] as prostaglandins have been shown to be induced by serotonin and are linked to hepatic fat accumulation. Results: NA treatment significantly increased Tph1 and Ido2 expression; this occurred in association with a significant increase in the expression of the inducible prostaglandin synthase Ptgs2 (COX-2), prostaglandin E synthase Ptges, and prostaglandin receptors Ptger2 and Ptger4. Acmsd was the only downstream enzyme in the kynurenine pathway that was significantly altered by NA treatment. Conclusion: These results provide proof-of-concept that compounds associated with oil sands extraction have the potential to perturb key components of serotonin synthesis (Tph1) and tryptophan metabolism (Ido2, Acmsd). Furthermore, we found that the increase in Tph1 expression paralleled expression of Ptgs2. As increased prostaglandin production has been reported in association with nonalcoholic steatohepatitis, these data provide a potential mechanism by which exposure to NA and other petroleum-based compounds may increase the risk of metabolic disease.

scholarly journals Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis

JCI Insight ◽  
2021 ◽  
Vol 6 (10) ◽  
Author(s):  
Shanu Jain ◽  
Sai P. Pydi ◽  
Young-Hwan Jung ◽  
Mirko Scortichini ◽  
Efrat L. Kesner ◽  
...  
Keyword(s):  
Whole Body ◽  
Lipid Homeostasis ◽  
Glucose And Lipid Homeostasis
Sign in / Sign up

Export Citation Format

Share Document