scholarly journals Fluctuations in isometric muscle force can be described by one linear projection of low-frequency components of motor unit discharge rates

2009 ◽  
Vol 587 (24) ◽  
pp. 5925-5938 ◽  
Author(s):  
Francesco Negro ◽  
Aleš Holobar ◽  
Dario Farina
Keyword(s):  
Motor Unit ◽  
Muscle Force ◽  
Low Frequency ◽  
Unit Discharge ◽  
Linear Projection ◽  
Discharge Rates ◽  
Motor Unit Discharge ◽  
Frequency Components ◽  
Isometric Muscle ◽  
Isometric Muscle Force

scholarly journals Exogenous neuromodulation of spinal neurons induces beta-band coherence during self-sustained discharge of hind limb motor unit populations

2019 ◽  
Vol 127 (4) ◽  
pp. 1034-1041
Author(s):  
Christopher K. Thompson ◽  
Michael D. Johnson ◽  
Francesco Negro ◽  
Laura Miller Mcpherson ◽  
Dario Farina ◽  
...  
Keyword(s):  
Motor Unit ◽  
Low Frequency ◽  
Motor Units ◽  
Intrathecal Administration ◽  
Spinal Motoneurons ◽  
Beta Band ◽  
Unit Discharge ◽  
Discharge Rates ◽  
Motor Unit Discharge ◽  
Sustained Discharge

The spontaneous or self-sustained discharge of spinal motoneurons can be observed in both animals and humans. Although the origins of this self-sustained discharge are not fully known, it can be generated by activation of persistent inward currents intrinsic to the motoneuron. If self-sustained discharge is generated exclusively through this intrinsic mechanism, the discharge of individual motor units will be relatively independent of one another. Alternatively, if increased activation of premotor circuits underlies this prolonged discharge of spinal motoneurons, we would expect correlated activity among motoneurons. Our aim is to assess potential synaptic drive by quantifying coherence during self-sustained discharge of spinal motoneurons. Electromyographic activity was collected from 20 decerebrate animals using a 64-channel electrode grid placed on the isolated soleus muscle before and following intrathecal administration of methoxamine, a selective α1-noradrenergic agonist. Sustained muscle activity was recorded and decomposed into the discharge times of ~10–30 concurrently active individual motor units. Consistent with previous reports, the self-sustained discharge of motor units occurred at low mean discharge rates with low-interspike variability. Before methoxamine administration, significant low-frequency coherence (<2 Hz) was observed, while minimal coherence was observed within higher frequency bands. Following intrathecal administration of methoxamine, increases in motor unit discharge rates and strong coherence in both the low-frequency and 15- to 30-Hz beta bands were observed. These data demonstrate beta-band coherence among motor units can be observed through noncortical mechanisms and that neuromodulation of spinal/brainstem neurons greatly influences coherent discharge within spinal motor pools. NEW & NOTEWORTHY The correlated discharge of spinal motoneurons is often used to describe the input to the motor pool. We demonstrate spinal/brainstem neurons devoid of cortical input can generate correlated motor unit discharge in the 15- to 30-Hz beta band, which is amplified through neuromodulation. Activity in the beta band is often ascribed to cortical drive in humans; however, these data demonstrate the capability of the mammalian segmental motor system to generate and modulate this coherent state of motor unit discharge.

Low-frequency common modulation of soleus motor unit discharge is enhanced during postural control in humans

2006 ◽  
Vol 175 (4) ◽  
pp. 584-595 ◽  
Author(s):  
G. Mochizuki ◽  
J. G. Semmler ◽  
T. D. Ivanova ◽  
S. J. Garland
Keyword(s):  
Postural Control ◽  
Motor Unit ◽  
Low Frequency ◽  
Unit Discharge ◽  
Motor Unit Discharge

scholarly journals Stroke increases ischemia-related decreases in motor unit discharge rates

2018 ◽  
Vol 120 (6) ◽  
pp. 3246-3256 ◽  
Author(s):  
Spencer A. Murphy ◽  
Francesco Negro ◽  
Dario Farina ◽  
Tanya Onushko ◽  
Matthew Durand ◽  
...  
Keyword(s):  
Motor Unit ◽  
Time Constant ◽  
Motor Units ◽  
Unit Discharge ◽  
Firing Rates ◽  
Sensory Pathways ◽  
Discharge Rates ◽  
Motor Unit Firing ◽  
Motor Unit Discharge ◽  
Density Surface

Following stroke, hyperexcitable sensory pathways, such as the group III/IV afferents that are sensitive to ischemia, may inhibit paretic motor neurons during exercise. We quantified the effects of whole leg ischemia on paretic vastus lateralis motor unit firing rates during submaximal isometric contractions. Ten chronic stroke survivors (>1 yr poststroke) and 10 controls participated. During conditions of whole leg occlusion, the discharge timings of motor units were identified from decomposition of high-density surface electromyography signals during repeated submaximal knee extensor contractions. Quadriceps resting twitch responses and near-infrared spectroscopy measurements of oxygen saturation as an indirect measure of blood flow were made. There was a greater decrease in paretic motor unit discharge rates during the occlusion compared with the controls (average decrease for stroke and controls, 12.3 ± 10.0% and 0.1 ± 12.4%, respectively; P < 0.001). The motor unit recruitment thresholds did not change with the occlusion (stroke: without occlusion, 11.68 ± 5.83%MVC vs. with occlusion, 11.11 ± 5.26%MVC; control: 11.87 ± 5.63 vs. 11.28 ± 5.29%MVC). Resting twitch amplitudes declined similarly for both groups in response to whole leg occlusion (stroke: 29.16 ± 6.88 vs. 25.75 ± 6.78 Nm; control: 38.80 ± 13.23 vs 30.14 ± 9.64 Nm). Controls had a greater exponential decline (lower time constant) in oxygen saturation compared with the stroke group (stroke time constant, 22.90 ± 10.26 min vs. control time constant, 5.46 ± 4.09 min; P < 0.001). Ischemia of the muscle resulted in greater neural inhibition of paretic motor units compared with controls and may contribute to deficient muscle activation poststroke. NEW & NOTEWORTHY Hyperexcitable inhibitory sensory pathways sensitive to ischemia may play a role in deficient motor unit activation post stroke. Using high-density surface electromyography recordings to detect motor unit firing instances, we show that ischemia of the exercising muscle results in greater inhibition of paretic motor unit firing rates compared with controls. These findings are impactful to neurophysiologists and clinicians because they implicate a novel mechanism of force-generating impairment poststroke that likely exacerbates baseline weakness.

scholarly journals Motor unit behavior during submaximal contractions following six weeks of either endurance or strength training

2010 ◽  
Vol 109 (5) ◽  
pp. 1455-1466 ◽  
Author(s):  
Carolina Vila-Chã ◽  
Deborah Falla ◽  
Dario Farina
Keyword(s):  
Strength Training ◽  
Endurance Training ◽  
Motor Unit ◽  
Conduction Velocity ◽  
Training Programs ◽  
Control Group ◽  
Unit Discharge ◽  
Task Failure ◽  
Discharge Rates ◽  
Motor Unit Discharge

The study investigated changes in motor output and motor unit behavior following 6 wk of either strength or endurance training programs commonly used in conditioning and rehabilitation. Twenty-seven sedentary healthy men (age, 26.1 ± 3.9 yr; mean ± SD) were randomly assigned to strength training (ST; n = 9), endurance training (ET; n = 10), or a control group (CT; n = 8). Maximum voluntary contraction (MVC), time to task failure (isometric contraction at 30% MVC), and rate of force development (RFD) of the quadriceps were measured before ( week 0), during ( week 3), and after a training program of 6 wk. In each experimental session, surface and intramuscular EMG signals were recorded from the vastus medialis obliquus and vastus lateralis muscles during isometric knee extension at 10 and 30% MVC. After 6 wk of training, MVC and RFD increased in the ST group (17.5 ± 7.5 and 33.3 ± 15.9%, respectively; P < 0.05), whereas time to task failure was prolonged in the ET group (29.7 ± 13.4%; P < 0.05). The surface EMG amplitude at 30% MVC force increased with training in both groups, but the training-induced changes in motor unit discharge rates differed between groups. After endurance training, the motor unit discharge rate at 30% MVC decreased from 11.3 ± 1.3 to 10.1 ± 1.1 pulses per second (pps; P < 0.05) in the vasti muscles, whereas after strength training it increased from 11.4 ± 1.2 to 12.7 ± 1.3 pps ( P < 0.05). Finally, motor unit conduction velocity during the contractions at 30% MVC increased for both the ST and ET groups, but only after 6 wk of training ( P < 0.05). In conclusion, these strength and endurance training programs elicit opposite adjustments in motor unit discharge rates but similar changes in muscle fiber conduction velocity.

Aging, Resistance Training, and Motor Unit Discharge Behavior

2005 ◽  
Vol 30 (3) ◽  
pp. 341-351 ◽  
Author(s):  
Gary Kamen
Keyword(s):  
Motor Unit ◽  
Muscular Strength ◽  
Discharge Rate ◽  
Recruitment Rate ◽  
Unit Discharge ◽  
Discharge Rates ◽  
Motor Unit Synchronization ◽  
Motor Unit Discharge ◽  
Rate Coding ◽  
Neural Factors

Researchers have alluded to the existence of "neural factors" in the expression and development of muscular strength. Candidate neural factors including motor unit recruitment, rate coding, doublet firing, and motor unit synchronization are discussed in this review. Aging is generally accompanied by lower motor unit discharge rates. However, both young and older adults exhibit rapid changes in muscular strength with repeated strength testing. These strength changes occur with concomitant albeit transient increases in motor unit discharge rate. These and other neural factors may contribute to the initial increases in muscular strength observed during the early phases of resistance exercise training. Key words: firing rate, muscle, exercise

Experimental muscle pain reduces initial motor unit discharge rates during sustained submaximal contractions

2005 ◽  
Vol 98 (3) ◽  
pp. 999-1005 ◽  
Author(s):  
Dario Farina ◽  
Lars Arendt-Nielsen ◽  
Thomas Graven-Nielsen
Keyword(s):  
Motor Unit ◽  
Conduction Velocity ◽  
Muscle Pain ◽  
Tibialis Anterior ◽  
Discharge Rate ◽  
Human Study ◽  
Unit Discharge ◽  
Discharge Rates ◽  
Motor Unit Discharge ◽  
The Right

The aim of this human study was to investigate the effect of experimentally induced muscle pain on the modifications of motor unit discharge rate during sustained, constant-force contractions. Intramuscular and multichannel surface electromyographic (EMG) signals were collected from the right and left tibialis anterior muscle of 11 volunteers. The subjects performed two 4-min-long isometric contractions at 25% of the maximal dorsiflexion torque, separated by a 20-min rest. Before the beginning of the second contraction, hypertonic (painful; right leg) or isotonic (nonpainful; left leg) saline was injected into the tibialis anterior. Pain intensity scores did not change significantly in the first 150 s of the painful contraction. Exerted torque and its coefficient of variation were the same for the painful and nonpainful contractions. Motor unit discharge rate was higher in the beginning of the nonpainful contraction than the painful contraction on the right side [means ± SE, 11.3 ± 0.2 vs. 10.6 ± 0.2 pulses/s (pps); P < 0.01] whereas it was the same for the two contractions on the left side (11.6 ± 0.2 vs. 11.5 ± 0.2 pps). The decrease in discharge rate in 4 min was smaller for the painful (0.4 ± 0.1 pps) than for the control contractions (1.3 ± 0.1 pps). Initial value and decrease in motor unit conduction velocity were not different in the four contractions (right leg, 4.0 ± 0.1 m/s with decrease of 0.6 ± 0.1 m/s in 4 min; left leg, 4.1 ± 0.1 m/s with 0.7 ± 0.1 m/s decrease). In conclusion, stimulation of nociceptive afferents by injection of hypertonic saline did not alter motor unit conduction velocity but reduced the initial motor unit discharge rates and the difference between initial and final discharge rates during sustained contraction.

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