A Clinical Test to Capture Humidity From Exhalation: Self-Humidification

Author(s):  
Sandra Grau-Bartual ◽  
Ahmed M. Al-Jumaily

Abstract Lung supportive devices are widely used for non-invasive positive airway pressure ventilation and respiratory therapy to help provide breathing support for patients with various lung diseases including Obstructive Sleep Apnea. These devices deliver air to the patient through a facial or nasal mask, and the use of these devices normally results in dryness in the upper airways. However, the exhaled air consists of very high humidity content hence the moisture content of this air can be reused in the inhalation process. This research focuses on testing clinically a previously developed element which can recover the moisture from the exhaled air and use it for re-inhalation. 21 healthy volunteers between the ages of 21 and 55, where 38.1% were females and 61.9% males, were invited to participate in this study. The results show a viable element which is able to trap water molecules from the expiration airflow and release them into the inspiration airflow.

Author(s):  
Sandra Grau-Bartual ◽  
Ahmed M. Al-Jumaily

Lung supportive devices (LSD) are widely used for respiratory ventilation and therapy to help provide breathing support for patients with various lung diseases including Obstructive Sleep Apnea. These devices deliver air to the patient through a nasal or facial mask, and the use of these devices normally results in dryness in the upper airways. However, the exhaled air consists of very high humidity content. The question raised, is it possible to recover some of the moisture content of this air to reuse in the inhalation process. This research focuses on developing an element which can recover the moisture from the exhaled air and the possibility of using it for re-inhalation. The main component is made up of a fibrous cotton fabric polymerized with Poly (N-isopropylacrylamide) (PNIPAM) and sewed with a resistor filament to control the temperature. The results show a viable element which is able to trap water molecules from the expiration airflow and release them into the inspiration airflow.


2020 ◽  
Vol 6 (2) ◽  
pp. 00327-2019
Author(s):  
Sandra Grau-Bartual ◽  
Ahmed M. Al-Jumaily ◽  
Paul M. Young ◽  
Daniela Traini ◽  
Maliheh Ghadiri

Continuous positive airway pressure (CPAP) therapy is the gold standard treatment for obstructive sleep apnoea, which affects millions of people worldwide. However, this therapy normally results in symptoms such as dryness, sneezing, rhinorrhoea, post-nasal drip, nasal congestion and epistaxis in the upper airways.Using bronchial epithelial (Calu-3) and nasal epithelial (RPMI 2650) cells in an in vitro respiratory model, this study, for the first time, investigates the effect of CPAP positive pressure on the human respiratory epithelial mechanisms that regulate upper airways lubrication characteristics. To understand how the epithelium and mucus are affected by this therapy, several parameters were determined before and after positive pressure application.This work demonstrates that the positive pressure not only compresses the cells, but also reduces their permeability and mucus secretion rate, thus drying the airway surface liquid layer and altering the mucus/water ratio. It is also observed that the respiratory epithelia is equally inflamed without or with external humidification during CPAP application.These findings clearly identify the causes of the side-effects reported by patients under CPAP therapy.


2019 ◽  
Vol 29 (7) ◽  
pp. 977-979
Author(s):  
Maria Boutsikou ◽  
Wei Li ◽  
Michael A. Gatzoulis

AbstractIn patients with CHD after Fontan palliation, there is a lack of a pumping chamber in the pulmonary circulation; thus, pulmonary blood flow and cardiac output are sensitive to increased pulmonary vascular resistance; if obstructive sleep apnoea is present, there are legitimate concerns from continuous positive airway pressure ventilation, which may hinder pulmonary blood flow.


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