scholarly journals Imaging of intrahepatic progression of hepatocellular carcinoma post transarterial chemoembolization. A long-term, prospective evaluation of contrast-enhanced ultrasonography (CEUS)

2017 ◽  
Vol 19 (2) ◽  
pp. 134 ◽  
Author(s):  
Hippocrates Moschouris ◽  
Mariana Kalokairinou-Motogna ◽  
Spyros Vrakas ◽  
Aggeliki Papadatou ◽  
Eyaggelos Karagiannis ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Prospective Evaluation ◽  
Diagnostic Efficacy ◽  
Contrast Enhanced ◽  
Major Vessel ◽  
Term Evaluation ◽  
Contrast Enhanced Ultrasonography

Aims: To assess the diagnostic efficacy of contrast-enhanced ultrasonography (CEUS) in the context of intrahepatic progression (IHP) of hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).Material and methods:Sixty HCC patients were prospectively included in the study. They were treated with transarterial chemoembolization (TACE)with doxorubicin-eluting microspheres (231 sessions). Imaging follow-up was performed 1 month after each session and at 3-6 month intervals after the last session of TACE and included CEUS and contrast-enhanced magnetic resonance (MR) imaging (reference modality). The diagnosis of IHP was based on mRECIST criteria and the respective findings of MR and CEUS were recorded, categorized and correlated.Results: A total of 441 CEUS studies were compared with the corresponding MR studies. During a follow-up period of 5-82 months (mean: 22 months), MR diagnosed 51 cases of IHP in 34/60 (56.6%) patients. CEUS correctly diagnosed 12/14 (85.7%) cases of IHP of target tumors, 2/5 (40%) cases of IHP of non-target tumors, 13/18 (72.2%) cases of distal and 6/9 (66.6%) cases of proximal new lesions, and 5/5 (100%) cases of major vessel involvement. On a per-lesion basis, CEUS was significantly inferior to MR in the detection of new lesions (p=0.002). No false positive CEUS diagnoses of IHP were observed. 54% of the diagnostic failures of CEUS were considered clinically significant.Conclusion: In the long term evaluation of HCC post TACE, CEUS appears to have limitations in the detection of IHP, which are more prominent in the case of new lesions and of progressive non-target tumors.

scholarly journals Long-term follow-up after conventional transarterial chemoembolization (c-TACE) with mitomycin for hepatocellular carcinoma (HCC)

2019 ◽  
Vol 10 (2) ◽  
pp. 348-353 ◽  
Author(s):  
Ricardo Yamada ◽  
Beatriz Bassaco ◽  
Stephen Bracewell ◽  
Kirkpatrick Gillen ◽  
Madison Kocher ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Long Term Follow Up

scholarly journals Contrast enhanced ultrasonography in assessing the treatment response to transarterial chemoembolization in patients with hepatocellular carcinoma.

2016 ◽  
Vol 18 (1) ◽  
pp. 96 ◽  
Author(s):  
Zeno Spârchez ◽  
Tudor Mocan ◽  
Pompilia Radu ◽  
Ofelia Anton ◽  
Nicolae Bolog
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Disease Free Survival ◽  
Early Assessment ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Current Guidelines

Abstract. The last decades have known continuous development of therapeutic strategies in hepatocellular carcinoma (HCC). Unfortunately the disease it still not diagnosed until it is already at an intermediate or even an advanced disease. In these circumstances transarterial chemoembolization (TACE) is considered an effective treatment for HCC. The most important independent prognostic factor of both disease free survival and overall survival is the presence of complete necrosis. Therefore, treatment outcomes are dictated by the proper use of radiological imaging. Current guidelines recommend contrast enhanced computer tomography (CECT) as the standard imaging technique for evaluating the therapeutic response in patients with HCC after TACE. One of the most important disadvantage of CECT is the overestimation of tumor response. As an attempt to overcome this limitation contrast enhanced ultrasound (CEUS) has gained particular attention as an imaging modality in HCC patients after TACE. Of all available imaging modalities, CEUS performs better in the early and very early assessment of TACE especially after lipiodol TACE. As any other imaging techniques CEUS has disadvantages especially in hypovascular tumors or in cases of tumor multiplicity. Not far from now the current limitations of CEUS will be overcome by the new CEUS techniques that are already tested in clinical practice such as dynamic CEUS with quantification, three-dimensional CEUS or fusion techniques.

Contrast Enhanced Ultrasonography in Diagnosis and Therapeutical Follow-up of Hepatocellular Carcinoma: A Case Report

2011 ◽  
Vol 37 (8) ◽  
pp. S105-S106
Author(s):  
S. Ioanitescu ◽  
M. Voiculescu ◽  
E. Mindrut ◽  
D. Pencu ◽  
A. Tirdea ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

Short-term evaluation of liver tumors after transarterial chemoembolization: limitations and feasibility of contrast-enhanced ultrasonography

2011 ◽  
Vol 36 (6) ◽  
pp. 718-728 ◽  
Author(s):  
Hippocrates Moschouris ◽  
Katerina Malagari ◽  
Marina Georgiou Papadaki ◽  
Ioannis Kornezos ◽  
Panagiotis Gkoutzios ◽  
...  
Keyword(s):  
Transarterial Chemoembolization ◽  
Liver Tumors ◽  
Short Term ◽  
Contrast Enhanced ◽  
Short Term Evaluation ◽  
Term Evaluation ◽  
Contrast Enhanced Ultrasonography
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