Epilepsy is caused by sudden abnormal discharges of neurons in the brain. This paper constructs an automatic seizure detection system, which combines the predicting result of multi-domain feature with the predicting result of spike rate feature to detect the occurrence of epileptic seizures. After segmenting EEG data into 5[Formula: see text]s with 80% overlap epochs, the paper extracts time domain features, frequency domain features and hurst exponents (HE) from each epoch and these features are reduced by linear discriminant analysis (LDA) to be input parameters of the random forest (RF) classifier, which provides classification of the EEG epochs concerning the existence of seizures. In parallel, the paper extracts spikes from EEG data with morphological filter and calculates the spike rate to determine whether there is seizure. Then the results obtained by these two methods are merged as the final detection result. The paper shows that the accuracy (AC), sensitivity (SE), specificity (SP) and the false positive ratio based on event (FPRE) obtained by hybrid method are 98.94%, 76.60%, 98.99% and 2.43 times/h, respectively. Finally, the paper applies the seizure detection method to do seizure warning and recording to help the family member to take care of the patients and the doctor to adjust the antiepileptic drugs (AEDs).
