Comparative dosimetry of diode and diamond detectors in electron beams for intraoperative radiation therapy

2000 ◽  
Vol 27 (11) ◽  
pp. 2580-2588 ◽  
Author(s):  
Peter Björk ◽  
Tommy Knöös ◽  
Per Nilsson
Keyword(s):  
Radiation Therapy ◽  
Electron Beams ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation

Synthetic single crystal diamond diode inclinical dosimetry of high dose per pulse electron beams for intraoperative radiation therapy (IORT)

2014 ◽  
Vol 30 ◽  
pp. e68-e69
Author(s):  
Marco Marinelli ◽  
G. Verona-Rinati ◽  
M.D. Falco ◽  
M. Pimpinella ◽  
S. De Stefano ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Single Crystal ◽  
Electron Beams ◽  
Intraoperative Radiation Therapy ◽  
High Dose ◽  
Pulse Electron ◽  
Intraoperative Radiation ◽  
Single Crystal Diamond

Characterization of high-dose-per-pulse intraoperative radiation therapy electron beams by using a microDiamond dosimeter

2016 ◽  
Vol 32 ◽  
pp. 22 ◽  
Author(s):  
M. Falco ◽  
M. Marinelli ◽  
A. Tonnetti ◽  
G. Verona Rinati ◽  
M. Pimpinella ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Electron Beams ◽  
Intraoperative Radiation Therapy ◽  
High Dose ◽  
Intraoperative Radiation

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

scholarly journals Intraoperative Radiation Therapy Combined with Hyperthermia against Pancreatic Carcinoma.

1992 ◽  
Vol 166 (3) ◽  
pp. 395-401 ◽  
Author(s):  
SHOGO YAMADA ◽  
YOSHIHIRO TAKAI ◽  
KENJI NEMOTO ◽  
YOSHIHIRO OGAWA ◽  
YOSHIHISA KAKUTO ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pancreatic Carcinoma ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation
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