In vitro and in vivo high‐frequency ultrasound response of microbubbles

2006 ◽  
Vol 119 (5) ◽  
pp. 3438-3438
Author(s):  
Orlando Aristizábal ◽  
Daniel H. Turnbull ◽  
Jeffrey A. Ketterling
Keyword(s):  
High Frequency ◽  
High Frequency Ultrasound ◽  
Frequency Ultrasound

scholarly journals Quantification of Endothelial αvβ3 Expression with High-Frequency Ultrasound and Targeted Microbubbles: In Vitro and In Vivo Studies

2016 ◽  
Vol 42 (9) ◽  
pp. 2283-2293 ◽  
Author(s):  
Verya Daeichin ◽  
Klazina Kooiman ◽  
Ilya Skachkov ◽  
Johan G. Bosch ◽  
Thomas L. Theelen ◽  
...  
Keyword(s):  
High Frequency ◽  
In Vivo Studies ◽  
High Frequency Ultrasound ◽  
Targeted Microbubbles ◽  
Frequency Ultrasound

2MHz ultrasound enhances t-PA-mediated thrombolysis: comparison of continuous versus pulsed ultrasound and standing versus travelling acoustic waves

2003 ◽  
Vol 89 (03) ◽  
pp. 583-589 ◽  
Author(s):  
Stefan Pfaffenberger ◽  
Branka Devcic-Kuhar ◽  
Karem El-Rabadi ◽  
Martin Gröschl ◽  
Walter Speidl ◽  
...  
Keyword(s):  
Wave Field ◽  
Acoustic Waves ◽  
High Frequency ◽  
Travelling Wave ◽  
High Frequency Ultrasound ◽  
Pulsed Ultrasound ◽  
Application Mode ◽  
Frequency Ultrasound

SummaryIn addition to fibrinolytic enzymes, ultrasound has the potential to enhance thrombolysis. High frequency ultrasound has the advantage that a combination of diagnostic and therapeutic ultrasound with only one device is possible. Therefore, we investigated the optimal high frequency (2 MHz) ultrasound field characteristics and application mode in vitro. Continuous ultrasound significantly enhanced rt-PA mediated thrombolysis: in a travelling wave field thrombolysis was augmented by 49.0 ± 14.7% and in a standing wave field by 34.8 ± 7.3%. In an intermittent application mode (1Hz, 10Hz, 100Hz, 1kHz) most efficient results were obtained for both wave fields using 1 Hz (46.4 ± 10.7% and 39.1 ± 6.6%, respectively). Referring to a possible in vivo application our in vitro data suggests that an intermittent application of a 2 MHz high frequency ultrasound using a travelling wave field would be the most potent application for lysing blood clots.

Arterial Thrombus Dissolution In Vivo Using a Transducer-Tipped, High-Frequency Ultrasound Catheter and Local Low-Dose Urokinase Delivery

2001 ◽  
Vol 8 (3) ◽  
pp. 282-290 ◽  
Author(s):  
Shaul Atar ◽  
Huai Luo ◽  
Tomoo Nagai ◽  
Roger A. Sahm ◽  
Michael C. Fishbein ◽  
...  
Keyword(s):  
High Frequency ◽  
Low Dose ◽  
High Frequency Ultrasound ◽  
Arterial Thrombus ◽  
Frequency Ultrasound

Abstract 245: Non-Invasive in vivo Assessment of the Re-Endothelialization Process Using Ultrasound Biomicroscopy in the Rat Carotid Artery Balloon Injury Model

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Samuel Röhl ◽  
Linnea Eriksson ◽  
Robert Saxelin ◽  
Mariette Lengquist ◽  
Kenneth Caidahl ◽  
...  
Keyword(s):  
Carotid Artery ◽  
High Frequency ◽  
Ultrasound Biomicroscopy ◽  
Blue Dye ◽  
High Frequency Ultrasound ◽  
Balloon Injury ◽  
En Face ◽  
In Vivo Assessment ◽  
Frequency Ultrasound

Objective: Ultrasound BioMicroscopy (UBM), or high-frequency ultrasound, is a novel technique used for assessment of anatomy and physiology small research animals. In this study, we evaluate the UBM assessment of the re-endothelialization process following denudation of the carotid artery in rats. Methods: Ultrasound BioMicroscopy data from three different experiments were analyzed. A total of 66 rats of three different strains (Sprague-Dawley, Wistar and Goto-Kakizaki) were included in this study. All animals were subjected to common carotid artery balloon injury and examined with UBM 2 and 4 weeks after injury. Re-endothelialization in UBM was measured as the length from the carotid bifurcation to the distal edge of the intimal hyperplasia. En face staining with Evans-blue dye was performed upon euthanization at 4 weeks after injury followed by tissue harvest for morphological and immunohistochemical evaluation. Results: A significant correlation (Spearman r=0.63,p<0.0001) and an agreement according to Bland-Altman test was identified when comparing all measurements of re-endothelialization in high frequency ultrasound and en face staining. Analysis by animal strain revealed a similar pattern and a significant growth in re-endothelialization length measured in UBM from 2 to 4 weeks could be identified. Immunohistochemical staining for von Willebrand factor confirmed the presence of endothelium in the areas detected as re-endothelialized by the ultrasound assessment. Conclusion: Ultrasound BioMicroscopy can be used for longitudinal in vivo assessment of the re-endothelialization following arterial injury in rats.

Ultra high frequency ultrasound: a promising technique to visualize pelvic floor meshes in vivo

2020 ◽  
Author(s):  
A. W. Kastelein ◽  
B. C. de Graaf ◽  
Y. P. Latul ◽  
K. W. J. Verhorstert ◽  
J. Holthof ◽  
...  
Keyword(s):  
Pelvic Floor ◽  
High Frequency ◽  
High Frequency Ultrasound ◽  
Promising Technique ◽  
Ultra High Frequency ◽  
Frequency Ultrasound

In Vitro Volume Imaging of Articular Cartilage Using Chirp-Coded High Frequency Ultrasound

2018 ◽  
Author(s):  
Anowarul Habib ◽  
Juha Vierinen ◽  
Ashraful Islam ◽  
Inigo Zubiavrre Martinez ◽  
Frank Melandso
Keyword(s):  
Articular Cartilage ◽  
High Frequency ◽  
High Frequency Ultrasound ◽  
Volume Imaging ◽  
Frequency Ultrasound

In vivo imaging of blood flow in the mouse Achilles tendon using high-frequency ultrasound

Ultrasonics ◽  
2009 ◽  
Vol 49 (2) ◽  
pp. 226-230 ◽  
Author(s):  
Chih-Kuang Yeh ◽  
Jia-Jiun Chen ◽  
Meng-Lin Li ◽  
Jer-Junn Luh ◽  
Jia-Jin Jason Chen
Keyword(s):  
Blood Flow ◽  
Achilles Tendon ◽  
In Vivo Imaging ◽  
High Frequency ◽  
High Frequency Ultrasound ◽  
Frequency Ultrasound
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