Age-related hearing loss, noise-induced hearing loss, and speech-understanding performance

2015 ◽  
Vol 137 (4) ◽  
pp. 2248-2248
Author(s):  
Larry E. Humes
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Speech Understanding ◽  
Age Related ◽  
Age Related Hearing Loss

FBXO3 Downregulation Attenuates Noise-induced Hearing Loss by Suppressing ATG10 Degradation and Activating Autophagy

2020 ◽  
Author(s):  
Fan Ye ◽  
Bi Lin ◽  
Lian Fang
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Underlying Mechanism ◽  
Noise Induced Hearing Loss ◽  
Age Related ◽  
Rat Cochlea ◽  
Model Treatment ◽  
Ear Injury ◽  
Age Related Hearing Loss

Abstract Noise induced hearing loss (NIHL) is a kind of hearing impairment, which is next to the age-related hearing loss. More and more evidences have verified that overproduction of reactive oxygen species is a common pathologic phenomenon of different inner ear injury including NIHL, and autophagy contributes to attenuate NIHL by reducing oxidative stress. However, the underlying mechanism by which noise exposure causes autophagy activation remains unclear. In this study, we found that NIHL was accompanied by autophagy in the rat cochlea. Furthermore, twelve common genes were found at the GEO datasets GSE85290 and GSE8342, and E3 ubiquitination ligase FBXO3 was confirmed significantly reduced in NIHL rat cochlea. Next, we demonstrated that FBXO3 can directly binding with autophagy-related protein 10 (ATG10), which is necessary for the initiation of autophagy, and mediate its degradation. In vivo animal model treatment with rapamycin, an autophagy activator, significantly reduced the NIHL. Based on these data, we confirmed that FBXO3 played an important role in autophagy caused by NIHL, may be a potential target of NIHL treatment.

Medical-Legal Assessment of Hearing Loss

1995 ◽  
Vol 112 (5) ◽  
pp. P75-P75
Author(s):  
Robert A. Dobie
Keyword(s):  
Hearing Loss ◽  
Time Course ◽  
Noise Induced Hearing Loss ◽  
Educational Objectives ◽  
Legal Assessment ◽  
Epidemiologic Data ◽  
Age Related ◽  
Exposure History ◽  
Age Related Hearing Loss

Educational objectives: To understand the epidemiology of noise-induced hearing loss (NIHL) and age-related hearing loss (ARHL), including time course, interactions, and importance of occupational and nonoccupational exposure history; to use clinical and epidemiologic data and principles to diagnose NIHL and ARHL; and to estimate the relative contributions of each in individual cases.

Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss

1996 ◽  
Vol 93 (1-2) ◽  
pp. 181-187 ◽  
Author(s):  
Lawrence C. Erway ◽  
Yea-Wen Shiau ◽  
Rickie R. Davis ◽  
Edward F. Krieg
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
F1 Hybrid ◽  
Age Related ◽  
Age Related Hearing Loss

Age-Related and Noise-Induced Hearing Loss

2018 ◽  
pp. 162-188
Author(s):  
Ruili Xie ◽  
Tessa-Jonne F. Ropp ◽  
Michael R. Kasten ◽  
Paul B. Manis
Keyword(s):  
Hearing Loss ◽  
Auditory Nerve ◽  
Transmitter Release ◽  
Time Course ◽  
Functional Change ◽  
Noise Induced Hearing Loss ◽  
Nerve Activity ◽  
Auditory Periphery ◽  
Age Related ◽  
Age Related Hearing Loss

Hearing loss generally occurs in the auditory periphery but leads to changes in the central auditory system. Noise-induced hearing loss (NIHL) and age-related hearing loss (ARHL) affect neurons in the ventral cochlear nucleus (VCN) at both the cellular and systems levels. In response to a decrease in auditory nerve activity associated with hearing loss, the large synaptic endings of the auditory nerve, the endbulbs of Held, undergo simplification of their structure and the volume of the postsynaptic bushy neurons decreases. A major functional change shared by NIHL and ARHL is the development of asynchronous transmitter release at endbulb synapses during periods of high afferent firing. Compensatory adjustements in transmitter release, including changes in release probability and quantal content, have also been reported. The excitability of the bushy cells undergoes subtle changes in the long-term, although short-term, reversible changes in excitability may also occur. These changes are not consistently observed across all models of hearing loss, suggesting that the time course of hearing loss, and potential developmental effects, may influence endbulb transmission in multiple ways. NIHL can alter the representation of the loudness of tonal stimuli by VCN neurons and is accompanied by changes in spontaneous activity in VCN neurons. However, little is known about the representation of more complex stimuli. The relationship between mechanistic changes in VCN neurons with noise-induced or age-related hearing loss, the accompanying change in sensory coding, and the reversibility of changes with the reintroduction of auditory nerve activity are areas that deserve further thoughtful exploration.

The inner ear

2019 ◽  
pp. 117-161
Author(s):  
Rogan Corbridge ◽  
Nicholas Steventon
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Bone Fractures ◽  
Auditory Neuropathy ◽  
Spectrum Disorder ◽  
Noise Induced Hearing Loss ◽  
Hearing Rehabilitation ◽  
Age Related ◽  
Age Related Hearing Loss

Conditions affecting the inner ear are delineated. Sensorineural hearing loss and its aetiologies are explored in reference to age-related hearing loss, noise-induced hearing loss, syndromic problems, and auditory neuropathy spectrum disorder. Causes of vertigo related to peripheral vestibular dysfunction are discussed, including vestibular migraine. Management of temporal bone fractures and their sequelae are explored. Methods of hearing rehabilitation are described.

Risk Factors of Age-related Hearing Loss, Adults over 65 Years in Korea: Including the Effect of the War Participation

2016 ◽  
Vol 17 (2) ◽  
pp. 68-73
Author(s):  
Dong-Wook Kim ◽  
Tae-Young Lee ◽  
Da-Hye Choi ◽  
Taek-Yeong Kim ◽  
Hyun-Chul Moon
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice

2021 ◽  
Vol 22 (6) ◽  
pp. 2853
Author(s):  
Judit Szepesy ◽  
Viktória Humli ◽  
János Farkas ◽  
Ildikó Miklya ◽  
Júlia Tímár ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
Dose Range ◽  
Auditory Brainstem ◽  
High Frequency Hearing Loss ◽  
Age Related ◽  
Hearing Function ◽  
Brainstem Response ◽  
Aging Societies ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL), a sensorineural hearing loss of multifactorial origin, increases its prevalence in aging societies. Besides hearing aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent ARHL. We hypothesized that selegiline, an antiparkinsonian drug, could be a promising candidate for the treatment due to its complex neuroprotective, antioxidant, antiapoptotic, and dopaminergic neurotransmission enhancing effects. We monitored by repeated Auditory Brainstem Response (ABR) measurements the effect of chronic per os selegiline administration on the hearing function in BALB/c and DBA/2J mice, which strains exhibit moderate and rapid progressive high frequency hearing loss, respectively. The treatments were started at 1 month of age and lasted until almost a year and 5 months of age, respectively. In BALB/c mice, 4 mg/kg selegiline significantly mitigated the progression of ARHL at higher frequencies. Used in a wide dose range (0.15–45 mg/kg), selegiline had no effect in DBA/2J mice. Our results suggest that selegiline can partially preserve the hearing in certain forms of ARHL by alleviating its development. It might also be otoprotective in other mammals or humans.

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