Structural and Functional Change in Albino Rat Retina Induced by Various Visible Light Wavelengths

The effects of visible light, from short to long wavelengths, on the retina were investigated functionally and histologically. The left eyes of Sprague–Dawley albino rats (6-weeks old, n = 6 for each wavelength) were exposed to seven narrow-band wavelengths (central wavelengths, 421, 441, 459, 501, 541, 581, and 615 nm) with bandwidths of 16 to 29 nm (half bandwidth, ±8–14.5 nm) using a xenon lamp source with bandpass filters at the retinal radiant exposures of 340 and 680 J/cm2. The right unexposed eyes served as controls. Seven days after exposure, flash electroretinograms (ERGs) were recorded, and the outer nuclear layer (ONL) thickness was measured. Compared to the unexposed eyes, significant reductions in the a- and b-wave ERG amplitudes were seen in eyes exposed to 460-nm or shorter wavelengths of light. The ONL thickness near the optic nerve head also tended to decrease with exposure to shorter wavelengths. The decreased ERG amplitudes and ONL thicknesses were most prominent in eyes exposed to 420-nm light at both radiant exposures. When the wavelengths were the same, the higher the amount of radiant exposure and the stronger the damage. Compared to the unexposed eyes, the a- and b-waves did not decrease significantly in eyes exposed to 500-nm or longer wavelength light. The results indicate that the retinal damage induced by visible light observed in albino rats depends on the wavelength and energy level of the exposed light.

Using child-friendly movie stimuli to study the development of face, place, and object regions from age 3 to 12 years

Scanning young children while watching short, engaging, commercially-produced movies has emerged as a promising approach for increasing data retention and quality. Movie stimuli also evoke a richer variety of cognitive processes than traditional experiments - allowing the study of multiple aspects of brain development simultaneously. However, because these stimuli are uncontrolled, it is unclear how effectively distinct profiles of brain activity can be distinguished from the resulting data. Here we develop an approach for identifying multiple distinct subject-specific Regions of Interest (ssROIs) using fMRI data collected during movie-viewing. We focused on the test case of higher-level visual regions selective for faces, scenes, and objects. Adults (N=13) were scanned while viewing a 5.5 minute child-friendly movie, as well as a traditional experiment with isolated faces, scenes, and objects. We found that just 2.7 minutes of movie data could identify subject-specific face, scene, and object regions. While successful, the movie approach was still less effective than a traditional localizer. Having validated our approach in adults, we then used the same methods on movie data collected from 3-12-year-old children (N=122). Movie response timecourses in 3-year-old childrens face, scene, and object regions were already significantly and specifically predicted by timecourses from the corresponding regions in adults. We also found evidence of continued developmental change, particularly in the face-selective posterior superior temporal sulcus. Taken together, our results reveal both early maturity and functional change in face, scene, and object regions, and more broadly highlight the promise of short, child-friendly movies for developmental cognitive neuroscience.

Transformation of former socialist industrial landscapes in Budapest

Budapest, the capital of Hungary, used to host numerous and diverse types of industrial activities. Their imprints on the urban fabric became especially significant during the socialist period due to the top-down decision of transferring the profile of the country from agricultural to industrial. They were realized in factories, management buildings, at huge areas supporting transport of goods on water or by trains. Moreover, districts were dedicated to the industrial workers and incorporated education, health and leisure services as well. Since the political change in 1989, most of these factories and organizations shrank then completely stopped to operate, but their premises have experienced a more varied after-life. The text introduces examples for almost entire physical elimination, complete functional change and even continuous musealizations of former industrial sites in Budapest. The investigation is based on the analysis of diverse written documents (such as policies, scientific evaluations and media coverage) as well as on-site research. Through the case study analyses from Budapest, Hungary that focus on the period between 1989 and 2016, the paper identifies general approaches of urbanization in the post-socialist time regarding to former industrial sites and the major challenges that threaten the valuation of these tangible and intangible reminiscences of the past.

Diagnosing Mild Cognitive Impairment Among Racially Diverse Older Adults: Comparison of Consensus, Actuarial, and Statistical Methods

Background: Actuarial and statistical methods have been proposed as alternatives to conventional methods of diagnosing mild cognitive impairment (MCI), with the aim of enhancing diagnostic and prognostic validity, but have not been compared in racially diverse samples. Objective: We compared the agreement of consensus, actuarial, and statistical MCI diagnostic methods, and their relationship to race and prognostic indicators among diverse older adults. Methods: Participants (N = 354; M age = 71; 68% White, 29% Black) were diagnosed with MCI or normal cognition (NC) according to clinical consensus, actuarial neuropsychological criteria (Jak/Bondi), and latent class analysis (LCA). We examined associations with race/ethnicity, longitudinal cognitive and functional change, and incident dementia. Results: MCI rates by consensus, actuarial criteria, and LCA were 44%, 53%, and 41%, respectively. LCA identified three MCI subtypes (memory; memory/language; memory/executive) and two NC classes (low normal; high normal). Diagnostic agreement was substantial, but agreement of the actuarial method with consensus and LCA was weaker than the agreement between consensus and LCA. Among cases classified as MCI by actuarial criteria only, Black participants were over-represented, and outcomes were generally similar to those of NC participants. Consensus diagnoses best predicted longitudinal outcomes overall, whereas actuarial diagnoses best predicted longitudinal functional change among Black participants. Conclusion: Consensus diagnoses optimize specificity in predicting dementia, but among Black older adults, actuarial diagnoses may be more sensitive to early signs of decline. Results highlight the need for cross-cultural validity in MCI diagnosis and should be explored in community- and population-based samples.

Urban Development and the (Re)use of the Communist-Built Industrial and Agricultural Sites after 1990. The Showcase of Bucharest–Ilfov Development Region

Urban development and changing the patterns of industry and agriculture had caused the foremost spatial and functional transformations of the post-communist period in Romania. These changes have resulted in increased land consumption, often including the reuse of abandoned or non-residential built-up areas (e.g., industrial, agricultural). By integrating spatial and statistical data, the current analysis has revealed as key features: spatial shrinkage, fragmentation, functional diversification, tertiarization and change of patterns. Using a functional change matrix, five main (re)use types have been identified and quantified: maintenance, conversion, replacement, abandonment, and demolition. Overall, between 1990 and 2018, over 50% functional losses have been recorded.

Dynamics Qf Urban Growth And Environmental Challenges: A Case Qf Kolkata, India

The history of development of Kolkata as a megacity in India dates back to 300 years. The scenario changed when the administrative headquarter of the British East India Company was established in erstwhile Calcutta, located at the bank of the River Hugli in the lower Gangetic plain. Since its inception, Kolkata has undergone rapid formal and functional change. Both national and international migration has led to the demographic explosion, urban industrial development and an increase in economic opportunities which caused environmental degradation. Until 1793, the urban dynamics of Kolkata followed a linear pattern along the left bank of the Hugli River. A similar trend continued along the right bank from 1793 to 1947 and extended up to its periphery post-independence. In this paper, an attempt was made to explore the influence of river ghats on the urban environment along the selected stretch of the River Hugli. Human activities like garbage disposal (0.089), sewage disposal (0.088) and idol immersion (0.084) have a negative impact on the river water. Secondly, this paper attempts to study the vertical expansion of Kolkata. It has been observed that the average height of buildings in the CBD area is 84.6 meters while along the peri-urban area it is only 10.61 meters proving the distance decay effect (R2 = 0.405 and R2 = 0.314). Besides, the mean values of DQ (5.179mg/l), BQD (8.5mg/l) and CQD (34.5mg/l) in the river water reflect the degrading water quality for the aquatic environment. Geospatial assessment techniques were used to understand the research problems and combat the environmental challenges. Complex functional development and decaying urban quality of life along the Hugli River has led to critical environmental transformation.

The difference in postoperative pulmonary functional change between upper and lower thoracoscopic lobectomy

OBJECTIVES Through 3-dimensional lung volumetric and morphological analyses, we aimed to evaluate the difference in postoperative functional changes between upper and lower thoracoscopic lobectomy. METHODS A total of 145 lung cancer patients who underwent thoracoscopic upper lobectomy (UL) were matched with 145 patients with lung cancer who underwent thoracoscopic lower lobectomy (LL) between April 2012 and December 2018, based on their sex, age, smoking history, operation side, and pulmonary function. Spirometry and computed tomography were performed before and 6 months after the operation. In addition, the postoperative pulmonary function, volume and morphological changes between the 2 groups were compared. RESULTS The rate of postoperative decreased and the ratio of actual to predicted postoperative forced expiratory volume in 1 s were significantly higher after LL than after UL (P < 0.001 for both). The tendency above was similar irrespective of the resected side. The postoperative actual volumes of the ipsilateral residual lobe and contralateral lung were larger than the preoperatively measured volumes in each side lobectomy. Moreover, the increased change was particularly remarkable in the middle lobe after right LL. The change in the D-value, representing the structural complexity of the lung, was better maintained in the left lung after LL than after UL (P = 0.042). CONCLUSIONS Pulmonary function after thoracoscopic LL was superior to that after UL because the upward displacement and the pulmonary reserves of the remaining lobe appeared more robust after LL.