Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability

R. S. Obach; G. S. Walker; M. A. Brodney

doi:10.1124/dmd.116.069310

Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability

Drug Metabolism and Disposition ◽

10.1124/dmd.116.069310 ◽

2016 ◽

Vol 44 (5) ◽

pp. 634-646 ◽

Cited By ~ 8

Author(s):

R. S. Obach ◽

G. S. Walker ◽

M. A. Brodney

Keyword(s):

Nuclear Magnetic Resonance ◽

Cytochrome P450 ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Metabolic Stability ◽

Resonance Spectroscopy ◽

Cytochrome P450 Enzymes ◽

Human Cytochrome ◽

Quantitative Nuclear Magnetic Resonance

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A Workup Protocol Combined with Direct Application of Quantitative Nuclear Magnetic Resonance Spectroscopy of Aqueous Samples from Large-Scale Steam Explosion of Biomass

ACS Omega ◽

10.1021/acsomega.0c05642 ◽

2021 ◽

Author(s):

Camilla Løhre ◽

Jarl Underhaug ◽

Rune Brusletto ◽

Tanja Barth

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Steam Explosion ◽

Large Scale ◽

Direct Application ◽

Resonance Spectroscopy ◽

Aqueous Samples ◽

Quantitative Nuclear Magnetic Resonance

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Same analytical method for both (bio)assay and zone isolation to identify/quantify bioactive compounds by quantitative nuclear magnetic resonance spectroscopy

Journal of Chromatography A ◽

10.1016/j.chroma.2020.461434 ◽

2020 ◽

Vol 1628 ◽

pp. 461434

Author(s):

Ebrahim Azadniya ◽

Luca Goldoni ◽

Tiziano Bandiera ◽

Gertrud E. Morlock

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Bioactive Compounds ◽

Analytical Method ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Bio Assay ◽

Nuclear Magnetic

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Determination and Validation of Piracetam in Pharmaceuticals Using Quantitative Nuclear Magnetic Resonance Spectroscopy

Analytical Chemistry Letters ◽

10.1080/22297928.2017.1320227 ◽

2017 ◽

Vol 7 (2) ◽

pp. 271-279

Author(s):

Sobhy M. El-Adl ◽

Mohamed E. El-sadek ◽

Marwa H. Hasan

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Assessment of the Purity of Emodin by Quantitative Nuclear Magnetic Resonance Spectroscopy and Mass Balance

Natural Product Sciences ◽

10.20307/nps.2019.25.3.222 ◽

2019 ◽

Vol 25 (3) ◽

pp. 222

Author(s):

Sojung Park ◽

Yu-Jin Choi ◽

Giang Hoang Do ◽

Eun Kyoung Seo ◽

Seunghun Hyun ◽

...

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Mass Balance ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Application of Quantitative Nuclear Magnetic Resonance Spectroscopy for the Determination of Amantadine and Acyclovir in Plasma and Pharmaceutical Samples

Journal of AOAC International ◽

10.5740/jaoacint.11-165 ◽

2012 ◽

Vol 95 (6) ◽

pp. 1644-1651 ◽

Cited By ~ 4

Author(s):

Alaa A. Salem ◽

Ibrahim M. Abdou ◽

Habiba A. Saleh

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Pharmaceutical Samples ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Hygroscopic Tendencies of Substances Used as Calibrants for Quantitative Nuclear Magnetic Resonance Spectroscopy

Analytical Chemistry ◽

10.1021/acs.analchem.1c04268 ◽

2021 ◽

Author(s):

Christopher L. Suiter ◽

Jason A. Widegren

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Analysis of coumarin and other compounds in commercially available cinnamon and cinnamon supplements utilizing quantitative Nuclear Magnetic Resonance Spectroscopy

Planta Medica ◽

10.1055/s-0035-1556196 ◽

2015 ◽

Vol 81 (11) ◽

Author(s):

KB Killday ◽

MA Markus ◽

C Fischer ◽

KL Colson

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b00116 ◽

2018 ◽

Vol 61 (8) ◽

pp. 3626-3640 ◽

Cited By ~ 13

Author(s):

R. Scott Obach ◽

Gregory S. Walker ◽

Raman Sharma ◽

Stephen Jenkinson ◽

Tuan P. Tran ◽

...

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Liver Microsomes ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Determination of fipronil and its metabolites in chicken egg by dispersive liquid–liquid microextraction with 19F quantitative nuclear magnetic resonance spectroscopy

Microchemical Journal ◽

10.1016/j.microc.2020.105547 ◽

2021 ◽

Vol 160 ◽

pp. 105547

Author(s):

Cong Wang ◽

Yao Lin ◽

Yichao Wang ◽

Ting-Fu Jiang ◽

Zhihua Lv

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Chicken Egg ◽

Quantitative Nuclear Magnetic Resonance ◽

Dispersive Liquid Liquid Microextraction ◽

Liquid Microextraction

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In SituDetermination of Fructose Isomer Concentrations in Wine Using13C Quantitative Nuclear Magnetic Resonance Spectroscopy

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.5b03641 ◽

2015 ◽

Vol 63 (38) ◽

pp. 8551-8559 ◽

Cited By ~ 8

Author(s):

Cinzia Colombo ◽

Clara Aupic ◽

Andrew R. Lewis ◽

B. Mario Pinto

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Quantitative Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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