scholarly journals Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin

2017 ◽  
Vol 46 (2) ◽  
pp. 109-121 ◽  
Author(s):  
Helen Gu ◽  
Catherine Dutreix ◽  
Sam Rebello ◽  
Taoufik Ouatas ◽  
Lai Wang ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Pbpk Modeling ◽  
Active Metabolites ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based ◽  
Drug Drug Interaction

scholarly journals In vitro and physiologically‐based pharmacokinetic based assessment of drug–drug interaction potential of canagliflozin

2016 ◽  
Vol 83 (5) ◽  
pp. 1082-1096 ◽  
Author(s):  
Rao N. V. S. Mamidi ◽  
Shannon Dallas ◽  
Carlo Sensenhauser ◽  
Heng Keang Lim ◽  
Ellen Scheers ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based ◽  
Drug Drug Interaction
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