Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Physiologically Based ◽

From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1782 ◽

2012 ◽

Vol 33 (2) ◽

pp. 111-121 ◽

Cited By ~ 49

Author(s):

Vikash Kumar Sinha ◽

Jan Snoeys ◽

Nancy Van Osselaer ◽

Achiel Van Peer ◽

Claire Mackie ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Oral Absorption ◽

Pbpk Modeling ◽

Modeling Approach ◽

Industrial Setting ◽

Physiologically Based ◽

Evaluation of the Drug–Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP ‐5862, Using a Physiologically‐Based Pharmacokinetic Modeling Approach

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12408 ◽

2019 ◽

Vol 8 (7) ◽

pp. 489-499 ◽

Cited By ~ 1

Author(s):

Diansong Zhou ◽

Terry Podoll ◽

Yan Xu ◽

Ganesh Moorthy ◽

Karthick Vishwanathan ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Active Metabolite ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based ◽

Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin

Drug Metabolism and Disposition ◽

10.1124/dmd.117.078006 ◽

2017 ◽

Vol 46 (2) ◽

pp. 109-121 ◽

Cited By ~ 12

Author(s):

Helen Gu ◽

Catherine Dutreix ◽

Sam Rebello ◽

Taoufik Ouatas ◽

Lai Wang ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pbpk Modeling ◽

Active Metabolites ◽

Physiologically Based ◽

Physiologically‐based pharmacokinetic modelling to predict oprozomib CYP3A drug–drug interaction potential in patients with advanced malignancies

British Journal of Clinical Pharmacology ◽

10.1111/bcp.13817 ◽

2018 ◽

Vol 85 (3) ◽

pp. 530-539 ◽

Cited By ~ 1

Author(s):

Ying Ou ◽

Yang Xu ◽

Lia Gore ◽

R. Donald Harvey ◽

Alain Mita ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic Modelling ◽

Advanced Malignancies ◽

Physiologically Based ◽

Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2134 ◽

2020 ◽

Author(s):

Jennifer Lang ◽

Ludwig Vincent ◽

Marylore Chenel ◽

Kayode Ogungbenro ◽

Aleksandra Galetin

Keyword(s):

Drug Interaction ◽

Literature Review ◽

Pharmacodynamic Modeling ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Critical Literature

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.01.007 ◽

2017 ◽

Vol 106 (5) ◽

pp. 1439-1451 ◽

Cited By ~ 11

Author(s):

Wen Lin ◽

Tao Ji ◽

Heidi Einolf ◽

Surya Ayalasomayajula ◽

Tsu-Han Lin ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based ◽

In vitro and physiologically‐based pharmacokinetic based assessment of drug–drug interaction potential of canagliflozin

British Journal of Clinical Pharmacology ◽

10.1111/bcp.13186 ◽

2016 ◽

Vol 83 (5) ◽

pp. 1082-1096 ◽

Cited By ~ 6

Author(s):

Rao N. V. S. Mamidi ◽

Shannon Dallas ◽

Carlo Sensenhauser ◽

Heng Keang Lim ◽

Ellen Scheers ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Physiologically Based ◽

A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12360 ◽

2018 ◽

Vol 7 (12) ◽

pp. 829-837 ◽

Cited By ~ 1

Author(s):

Christian Lüpfert ◽

Martin Dyroff ◽

Oliver von Richter ◽

Dieter Gallemann ◽

Samer El Bawab ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Interaction Potential ◽

Pbpk Modeling ◽

Modeling Approach ◽

Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacokinetics ◽

10.1007/s40262-016-0412-5 ◽

2016 ◽

Vol 55 (11) ◽

pp. 1435-1445 ◽

Cited By ~ 16

Author(s):

Nageshwar R. Budha ◽

Tao Ji ◽

Luna Musib ◽

Steve Eppler ◽

Mark Dresser ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Modeling And Simulation ◽

Interaction Potential ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based ◽

Simulation and Prediction of the Drug‐Drug Interaction Potential of Naloxegol by Physiologically Based Pharmacokinetic Modeling

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12070 ◽

2016 ◽

Vol 5 (5) ◽

pp. 250-257 ◽

Cited By ~ 22

Author(s):

D Zhou ◽

K Bui ◽

M Sostek ◽

N Al‐Huniti

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based ◽