Quantitative in Vivo Microdialysis Study on the Influence of Multidrug Transporters on the Blood-Brain Barrier Passage of Oxcarbazepine: Concomitant Use of Hippocampal Monoamines as Pharmacodynamic Markers for the Anticonvulsant Activity

2005 ◽  
Vol 314 (2) ◽  
pp. 725-731 ◽  
Author(s):  
Ralph Clinckers ◽  
Ilse Smolders ◽  
Alfred Meurs ◽  
Guy Ebinger ◽  
Yvette Michotte
Keyword(s):  
Blood Brain Barrier ◽  
Anticonvulsant Activity ◽  
In Vivo Microdialysis ◽  
Brain Barrier ◽  
Multidrug Transporters ◽  
Blood Brain ◽  
Pharmacodynamic Markers ◽  
Microdialysis Study

Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study

2002 ◽  
Vol 80 (7) ◽  
pp. 670-678 ◽  
Author(s):  
Michel Diserbo ◽  
Arnaud Agin ◽  
Ioannis Lamproglou ◽  
Jérôme Mauris ◽  
Fatiha Staali ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Radiation Effects ◽  
In Vivo Microdialysis ◽  
Brain Barrier ◽  
Whole Body ◽  
Moderate Dose ◽  
Blood Brain ◽  
Bbb Permeability ◽  
Microdialysis Study

The effects of total-body irradiation on the permeability of rat striatal blood-brain barrier (BBB) to [3H]alpha-aminoisobutyric acid (AIBA) and [14C]sucrose were investigated using the microdialysis technique. Seven days, 3 and 6 weeks, and 3, 5, and 8 months after gamma exposure at a dose of 4.5 Gy, no modification of the permeability to both [3H]AIBA and [14C]sucrose was observed. But, in the course of the initial syndrome, we observed a significant but transient increase in the BBB permeability to the two markers between 3 and 17 h after exposure. A secondary transient "opening" of the BBB to [14C]sucrose was noticed about 28 h following irradiation without the corresponding increase in BBB permeability to [3H]AIBA. On the contrary, the transport of [3H]AIBA through the BBB was decreased between 33 and 47 h postradiation. In conclusion, our experiments showed early modifications of BBB permeability after a moderate-dose whole-body exposure. Confirmation of these results with other tracers, in another experimental model or in humans, would have clinical applications for designing appropriate pharmacotherapy in radiotherapy and treatment of accidental overexposure.Key words: radiation effects, central nervous system, blood-brain barrier, moderate dose, microdialysis.

1-Benzyl-1,2,3,4-tetrahydroisoquinoline passes through the blood–brain barrier of rat brain: An in vivo microdialysis study

2006 ◽  
Vol 395 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Yaru Song ◽  
Yangzheng Feng ◽  
Michael H. LeBlanc ◽  
Neal Castagloni ◽  
Yi-Ming Liu
Keyword(s):  
Rat Brain ◽  
Blood Brain Barrier ◽  
In Vivo Microdialysis ◽  
Brain Barrier ◽  
Blood Brain ◽  
Microdialysis Study

scholarly journals In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study

2013 ◽  
Vol 127 (3) ◽  
pp. 342-352 ◽  
Author(s):  
Gary N. Y. Chan ◽  
Victor Saldivia ◽  
Yingbo Yang ◽  
Henrianna Pang ◽  
Inés de Lannoy ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Intracerebral Microdialysis ◽  
Mouse Blood ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Microdialysis Study ◽  
In Vivo Induction
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