Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.114.213694 ◽

2014 ◽

Vol 349 (3) ◽

pp. 535-548 ◽

Author(s):

Klaus Linz ◽

Thomas Christoph ◽

Thomas M. Tzschentke ◽

Thomas Koch ◽

Klaus Schiene ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Orphanin Fq ◽

Opioid Receptor Agonist

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Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

Pharmacology Research & Perspectives ◽

10.1002/prp2.247 ◽

2016 ◽

Vol 4 (4) ◽

Author(s):

Anna Rizzi ◽

Maria Camilla Cerlesi ◽

Chiara Ruzza ◽

Davide Malfacini ◽

Federica Ferrari ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Orphanin Fq ◽

Pharmacological Characterization ◽

Opioid Receptor Agonist

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Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain

Pain Practice ◽

10.1111/papr.12558 ◽

2017 ◽

Vol 17 (8) ◽

pp. 1032-1041 ◽

Author(s):

Thomas M. Tzschentke ◽

Klaus Linz ◽

Stefanie Frosch ◽

Thomas Christoph

Keyword(s):

Neuropathic Pain ◽

Opioid Receptor ◽

Receptor Agonist ◽

Rodent Models ◽

Central Administration ◽

Orphanin Fq ◽

Opioid Receptor Agonist ◽

Antinociceptive Effects

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Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain

Inflammopharmacology ◽

10.1007/s10787-017-0405-5 ◽

2017 ◽

Vol 26 (2) ◽

pp. 361-374 ◽

Author(s):

Kinga Sałat ◽

Anna Furgała ◽

Robert Sałat

Keyword(s):

Neuropathic Pain ◽

Mouse Models ◽

Opioid Receptor ◽

Receptor Agonist ◽

Orphanin Fq ◽

Opioid Receptor Agonist

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Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist

British Journal of Anaesthesia ◽

10.1093/bja/aeu332 ◽

2015 ◽

Vol 114 (3) ◽

pp. 364-366 ◽

Author(s):

D.G. Lambert ◽

M.F. Bird ◽

D.J. Rowbotham

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Orphanin Fq ◽

Opioid Receptor Agonist

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A Novel κ-Opioid Receptor Agonist, TRK-820, Blocks the Development of Physical Dependence on Morphine in Mice

Life Sciences ◽

10.1016/s0024-3205(00)00582-8 ◽

2000 ◽

Vol 66 (21) ◽

pp. PL353-PL358 ◽

Author(s):

M Tsuji

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Physical Dependence ◽

Opioid Receptor Agonist

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The G protein-biased kappa opioid receptor agonist 6′-GNTI blocks hippocampal paroxysmal discharges without inducing aversion

Intrinsic Activity ◽

10.25006/ia.3.s2-a2.14 ◽

2015 ◽

Vol 3 (Suppl. 2) ◽

pp. A2.14

Author(s):

Luca Zangrandi

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Agonist

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Faculty Opinions recommendation of Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1086845.539776 ◽

2007 ◽

Author(s):

Howard Fields

Keyword(s):

Receptor Antagonist ◽

Conditioned Place Preference ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Place Preference ◽

Delta Opioid Receptor ◽

Bivalent Ligands ◽

Mu Opioid ◽

Opioid Receptor Agonist

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Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5'-guanidinonaltrindole and the biased kappa opioid receptor agonist 6'-guanidinonaltrindole in mice

Medicine in Drug Discovery ◽

10.1016/j.medidd.2021.100097 ◽

2021 ◽

pp. 100097

Author(s):

Alan Cowan ◽

Lee-Yuan Liu-Chen ◽

Saadet Inan

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Common Effect ◽

Opioid Receptor Agonist

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Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on Respiratory Depression: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Clinical and Translational Science ◽

10.1111/cts.13042 ◽

2021 ◽

Author(s):

Eugene R. Viscusi ◽

Marc C. Torjman ◽

Catherine L. Munera ◽

Joseph W. Stauffer ◽

Beatrice S. Setnik ◽

...

Keyword(s):

Respiratory Depression ◽

Opioid Receptor ◽

Receptor Agonist ◽

Controlled Trial ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Double Blind ◽

Double Blind Placebo ◽

Opioid Receptor Agonist

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Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H

Alcohol ◽

10.1016/j.alcohol.2009.05.001 ◽

2009 ◽

Vol 43 (5) ◽

pp. 359-365 ◽

Author(s):

Marian L. Logrip ◽

Patricia H. Janak ◽

Dorit Ron

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Agonist

Download Full-text