scholarly journals Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential

2017 ◽  
Vol 363 (1) ◽  
pp. 66-79 ◽  
Author(s):  
A. J. Brock ◽  
S. M. G. Goody ◽  
A. N. Mead ◽  
A. Sudwarts ◽  
M.O. Parker ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Abuse Potential ◽  
Preference Model

Neural Circuits Associated with 5-HT1BReceptor Agonist Inhibition of Methamphetamine Seeking in the Conditioned Place Preference Model

2019 ◽  
Vol 10 (7) ◽  
pp. 3271-3283 ◽  
Author(s):  
Taleen S. Der-Ghazarian ◽  
Delaram Charmchi ◽  
Sean N. Noudali ◽  
Samantha N. Scott ◽  
Michael C. Holter ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Neural Circuits ◽  
Place Preference ◽  
Preference Model

In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol

Synapse ◽  
2001 ◽  
Vol 43 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Jon E. Sprague ◽  
Michael Leifheit ◽  
Jennifer Selken ◽  
Michael M. Milks ◽  
David H. Kinder ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
In Vivo Microdialysis ◽  
Place Preference ◽  
Abuse Potential

scholarly journals Regional expression of extracellular signal-regulated kinase 1 and 2 mRNA in a morphine-induced conditioned place preference model

2014 ◽  
Vol 1543 ◽  
pp. 191-199 ◽  
Author(s):  
Jing Yuan Ma ◽  
Shan Zhi Gu ◽  
Min Meng ◽  
Yong Hui Dang ◽  
Chong Ya Huang ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Preference Model ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Test of the Popular Benzodiazepine Alprazolam in a Positive Conditioned Place-Preference Model in Female Rats

2021 ◽  
Vol 12 (05) ◽  
pp. 100-108
Author(s):  
Cheyenne Moffett ◽  
Katherine J. Kost ◽  
Austen Thompson ◽  
Michael H. Ossipov ◽  
Joseph V. Pergolizzi Jr. ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Female Rats ◽  
Preference Model

Assessment of the abuse potential of MDMA in the conditioned place preference paradigm: Role of CB1 receptors

2013 ◽  
Vol 47 ◽  
pp. 77-84 ◽  
Author(s):  
Marta Rodríguez-Arias ◽  
Olga Valverde ◽  
Manuel Daza-Losada ◽  
M. Carmen Blanco-Gandía ◽  
María A. Aguilar ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Abuse Potential ◽  
Cb1 Receptors ◽  
Conditioned Place Preference Paradigm

scholarly journals Effects of imidazoline agents in a rat conditioned place preference model of addiction

2022 ◽  
Author(s):  
V. Şorodoc ◽  
G. Rusu-Zota ◽  
P. Nechita ◽  
C. Moraru ◽  
O. M. Manole
Keyword(s):  
Central Nervous System ◽  
Conditioned Place Preference ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Place Preference ◽  
Receptor Ligands ◽  
Preference Model ◽  
Beneficial Effects ◽  
Central Nervous System Disorders ◽  
Male Wistar Rats

AbstractAgmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance.

Two newly-emerging substituted phenethylamines MAL and BOD induce differential psychopharmacological effects in rodents

2020 ◽  
Vol 34 (9) ◽  
pp. 1056-1067 ◽  
Author(s):  
Raly James Perez Custodio ◽  
Leandro Val Sayson ◽  
Chrislean Jun Botanas ◽  
Arvie Abiero ◽  
Mikyung Kim ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptor ◽  
Conditioned Place Preference ◽  
Dopaminergic System ◽  
Wave Activity ◽  
Place Preference ◽  
Abuse Potential ◽  
Brain Wave ◽  
Brain Wave Activity ◽  
Substituted Phenethylamines

Background: Recently, the recreational use of substituted phenethylamines has grown rapidly. Among these are 2-(3,5-dimethoxy-4-((2-methylallyl)oxy)phenyl)ethanamine (MAL) and 2-(2,5-dimethoxy-4-methylphenyl)-2-methoxyethan-1-amine (BOD). However, studies characterizing their abuse potential are still lacking. Aim: The purpose of this study was to investigate the abuse potential of MAL and BOD. Methods: The psychostimulant, reinforcing, and rewarding properties of MAL and BOD were analyzed using locomotor sensitization, self-administration, and conditioned place preference tests. Dopamine antagonists (i.e. SCH23390, haloperidol) were administered during conditioned place preference to evaluate the involvement of the mesolimbic dopamine system. Furthermore, dopamine-related protein expression in the nucleus accumbens and the ventral tegmental area was measured along with dopamine concentrations in the nucleus accumbens. Electroencephalography was conducted to determine effects of MAL and BOD on brain wave activity. Results: MAL induced psychostimulant effects and sensitization, while BOD induced locomotor depression in mice. Only MAL was self-administered by rats. Both drugs induced conditioned place preference in mice at different doses; dopamine receptor antagonists blocked MAL- and BOD-induced conditioned place preference. Both the compounds altered the expression of dopamine receptor D1 and D2 proteins in the nucleus accumbens and tyrosine hydroxylase (TH) and dopamine transporter in the ventral tegmental area, enhanced dopamine levels in the nucleus accumbens, and increased delta and gamma wave activities in the brain. Conclusions: MAL may induce abuse potential via the mesolimbic dopaminergic system and possibly accompanied by alterations in brain wave activity. Moreover, the lack of rewarding and reinforcing effects in BOD suggest that this drug may have little to no capability to engender compulsive behavior, though having found to induce alterations in dopaminergic system and brain wave activities.

Methoxetamine, a ketamine derivative, produced conditioned place preference and was self-administered by rats: Evidence of its abuse potential

2015 ◽  
Vol 133 ◽  
pp. 31-36 ◽  
Author(s):  
Chrislean Jun Botanas ◽  
June Bryan de la Peña ◽  
Irene Joy dela Peña ◽  
Reinholdgher Tampus ◽  
Robin Yoon ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Abuse Potential
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