scholarly journals Test of the Popular Benzodiazepine Alprazolam in a Positive Conditioned Place-Preference Model in Female Rats

2021 ◽  
Vol 12 (05) ◽  
pp. 100-108
Author(s):  
Cheyenne Moffett ◽  
Katherine J. Kost ◽  
Austen Thompson ◽  
Michael H. Ossipov ◽  
Joseph V. Pergolizzi Jr. ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Female Rats ◽  
Preference Model

scholarly journals Vulnerability factors for mephedrone-induced conditioned place preference in rats—the impact of sex differences, social-conditioning and stress

2021 ◽  
Author(s):  
Olga Wronikowska ◽  
Maria Zykubek ◽  
Łukasz Kurach ◽  
Agnieszka Michalak ◽  
Anna Boguszewska-Czubara ◽  
...  
Keyword(s):  
Sex Differences ◽  
Conditioned Place Preference ◽  
Low Dose ◽  
Social Factor ◽  
Place Preference ◽  
Female Rats ◽  
Male Rats ◽  
Social Conditioning ◽  
Male And Female Rats ◽  
The Impact

Abstract Rationale Mephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of action, as well as toxic and psychoactive effects, has been widely studied, the role of different factors that could contribute to the increased vulnerability to mephedrone abuse is still poorly understood. Objectives The aim of the presented study was to assess the impact of several factors (sex differences, social-conditioning, and chronic mild unpredictable stress — CMUS) on the liability to mephedrone-induced reward in Wistar rats. Methods The rewarding effects of mephedrone in male and female rats were assessed using the conditioned place preference (CPP) procedure. Furthermore, the impact of social factor and stress was evaluated in male rats using social-CPP and CMUS-dependent CPP, respectively. Results Mephedrone induced classic-CPP in female (10 mg/kg), as well as in male (10 and 20 mg/kg) rats. However, the impact of mephedrone treatment during social-CPP was highly dose-dependent as the rewarding effects of low dose of mephedrone (5 mg/kg; non-active in classic-CPP) were potentiated when administered during social-conditioning. Interestingly, social-conditioning with a higher dose of 20 mg/kg (that induced classic-CPP) was able to reverse these effects. Finally, CMUS potentiated rewarding effects of a low dose of mephedrone (5 mg/kg) and increased the level of corticosterone in rats’ prefrontal cortex and hippocampus. Conclusions Altogether, the presented results give new insight into possible factors underlying the vulnerability to mephedrone abuse and can serve as a basis for further studies assessing mechanisms underlying observed effects.

scholarly journals Isolation stress during adolescence increases conditioned place preference to cocaine in female rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Carlos J. Rivero ◽  
Jaime A. Freire ◽  
Ivan Santiago ◽  
Cristian Delgado ◽  
Annabell C. Segarra
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Female Rats ◽  
Isolation Stress

Neural Circuits Associated with 5-HT1BReceptor Agonist Inhibition of Methamphetamine Seeking in the Conditioned Place Preference Model

2019 ◽  
Vol 10 (7) ◽  
pp. 3271-3283 ◽  
Author(s):  
Taleen S. Der-Ghazarian ◽  
Delaram Charmchi ◽  
Sean N. Noudali ◽  
Samantha N. Scott ◽  
Michael C. Holter ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Neural Circuits ◽  
Place Preference ◽  
Preference Model

Prepubertal ovariectomy modulates paced mating behavior but not sexual preference or conditioned place preference for mating in female rats

2017 ◽  
Vol 171 ◽  
pp. 142-148 ◽  
Author(s):  
Sarah H. Meerts ◽  
Kelly S. Anderson ◽  
Molly E. Farry-Thorn ◽  
Elliott G. Johnson ◽  
Lisa Taxier
Keyword(s):  
Mating Behavior ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Sexual Preference ◽  
Female Rats

scholarly journals Regional expression of extracellular signal-regulated kinase 1 and 2 mRNA in a morphine-induced conditioned place preference model

2014 ◽  
Vol 1543 ◽  
pp. 191-199 ◽  
Author(s):  
Jing Yuan Ma ◽  
Shan Zhi Gu ◽  
Min Meng ◽  
Yong Hui Dang ◽  
Chong Ya Huang ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Preference Model ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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