Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced IL-1β Production

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.120.000321 ◽

2020 ◽

pp. JPET-AR-2020-000321

Author(s):

Marwa M Qadri ◽

Sandy ElSayed ◽

Khaled A Elsaid

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Human Monocytes ◽

Monosodium Urate ◽

Phosphatase 2A ◽

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Fingolimod (FTY720) Activates Protein Phosphatase‐2A in Human Monocytes and Inhibits Uric Acid Crystal‐Induced Interleukin‐1 Beta Production

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.02386 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

Sandy Elsayed ◽

Marwa Qadri ◽

Khaled Elsaid

Keyword(s):

Uric Acid ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Interleukin 1 ◽

Human Monocytes ◽

Interleukin 1 Beta ◽

Uric Acid Crystal ◽

Acid Crystal ◽

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Auxin transportGarbers, C., DeLong, A., Deruére, J., Bernasconi, P. and Söll, D. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis, EMBO J. 15, 2115–2124

Trends in Plant Science ◽

10.1016/s1360-1385(96)86891-0 ◽

1996 ◽

Vol 1 (7) ◽

pp. 211-211

Keyword(s):

Protein Phosphatase ◽

Auxin Transport ◽

Protein Phosphatase 2A ◽

Regulatory Subunit ◽

Subunit A ◽

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Faculty Opinions recommendation of Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009236.125458 ◽

2002 ◽

Author(s):

Andreas Wodarz

Keyword(s):

Tight Junction ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Tight Junction Complex ◽

Atypical Pkc ◽

Phosphatase 2A ◽

Epithelial Tight Junction

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Faculty Opinions recommendation of Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012648.186405 ◽

2003 ◽

Author(s):

Martin A Schwartz

Keyword(s):

Protein Kinase ◽

Protein Phosphatase ◽

Protein Kinase B ◽

Protein Phosphatase 2A ◽

Local Activation ◽

Phosphatase 2A ◽

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Faculty Opinions recommendation of Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023795.367924 ◽

2006 ◽

Author(s):

Jonathan Millar

Keyword(s):

Sister Chromatid ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Sister Chromatid Cohesion ◽

Chromatid Cohesion ◽

Phosphatase 2A ◽

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Faculty Opinions recommendation of Generation of active protein phosphatase 2A is coupled to holoenzyme assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087308.540326 ◽

2007 ◽

Author(s):

Ian Willis

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Active Protein ◽

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Faculty Opinions recommendation of REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718505432.793499740 ◽

2014 ◽

Author(s):

Rony Seger ◽

Zhong Yao

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Mtorc1 Signaling ◽

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Faculty Opinions recommendation of The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7352956.10037054 ◽

2011 ◽

Author(s):

Philipp Kaldis

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Phosphatase 2A ◽

Greatwall Kinase ◽

Inhibiting Protein

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Faculty Opinions recommendation of Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737780631.793577330 ◽

2020 ◽

Author(s):

Brion Murray

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

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The Structure of Protein Phosphatase 2A and Its Inhibition of Tumorigenesis

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS ◽

10.3724/sp.j.1206.2008.00420 ◽

2009 ◽

Vol 2009 (2) ◽

pp. 133-142

Author(s):

Tian-Zhu LI ◽

Ben-Qiong XIANG

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

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