Faculty Opinions recommendation of Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737780631.793577330 ◽

2020 ◽

Author(s):

Brion Murray

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

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Faculty Opinions recommendation of Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737780631.793577218 ◽

2020 ◽

Author(s):

Angus Nairn ◽

Shannon Leslie

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

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Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

Cell ◽

10.1016/j.cell.2020.03.051 ◽

2020 ◽

Vol 181 (3) ◽

pp. 702-715.e20 ◽

Author(s):

Ken Morita ◽

Shuning He ◽

Radosław P. Nowak ◽

Jinhua Wang ◽

Mark W. Zimmerman ◽

...

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

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Abstract LB-193: Protein phosphatase 2A inhibition,with a novel small molecule inhibitor, LB-100, achieves durable immune-mediated antitumor activity when combined with PD1 blockade in a preclinical model

10.1158/1538-7445.am2017-lb-193 ◽

2017 ◽

Author(s):

Winson S. Ho ◽

Herui Wang ◽

John S. Kovach ◽

Rongze Lu ◽

Zhengping Zhuang

Keyword(s):

Antitumor Activity ◽

Small Molecule ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Small Molecule Inhibitor ◽

Preclinical Model ◽

Immune Mediated ◽

Molecule Inhibitor ◽

Phosphatase 2A ◽

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Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade

Nature Communications ◽

10.1038/s41467-018-04425-z ◽

2018 ◽

Vol 9 (1) ◽

Author(s):

Winson S. Ho ◽

Herui Wang ◽

Dominic Maggio ◽

John S. Kovach ◽

Qi Zhang ◽

...

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Immune Mediated ◽

Phosphatase 2A ◽

Pharmacologic Inhibition

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67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance

Journal of Biological Chemistry ◽

10.1074/jbc.m114.604983 ◽

2014 ◽

Vol 289 (47) ◽

pp. 32671-32681 ◽

Author(s):

Shuntaro Tsukamoto ◽

Yuhui Huang ◽

Daisuke Umeda ◽

Shuhei Yamada ◽

Shuya Yamashita ◽

...

Keyword(s):

Drug Resistance ◽

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Laminin Receptor ◽

Phosphatase 2A ◽

Dependent Protein ◽

Pp2a Activation

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IMMU-55. PHARMACOLOGIC INHIBITION OF PROTEIN PHOSPHATASE-2A, WITH NOVEL INHIBITOR LB-100, ACHIEVES DURABLE IMMUNE-MEDIATED ANTITUMOR ACTIVITY WHEN COMBINED WITH PD1 BLOCKADE

Neuro-Oncology ◽

10.1093/neuonc/nox168.513 ◽

2017 ◽

Vol 19 (suppl_6) ◽

pp. vi125-vi125

Author(s):

Winson SC Ho ◽

Herui Wang ◽

Kovach John ◽

Dominic Maggio ◽

John Heiss ◽

...

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Immune Mediated ◽

Phosphatase 2A ◽

Pd1 Blockade ◽

Pharmacologic Inhibition

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Auxin transportGarbers, C., DeLong, A., Deruére, J., Bernasconi, P. and Söll, D. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis, EMBO J. 15, 2115–2124

Trends in Plant Science ◽

10.1016/s1360-1385(96)86891-0 ◽

1996 ◽

Vol 1 (7) ◽

pp. 211-211

Keyword(s):

Protein Phosphatase ◽

Auxin Transport ◽

Protein Phosphatase 2A ◽

Regulatory Subunit ◽

Subunit A ◽

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Faculty Opinions recommendation of Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009236.125458 ◽

2002 ◽

Author(s):

Andreas Wodarz

Keyword(s):

Tight Junction ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Tight Junction Complex ◽

Atypical Pkc ◽

Phosphatase 2A ◽

Epithelial Tight Junction

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Faculty Opinions recommendation of Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012648.186405 ◽

2003 ◽

Author(s):

Martin A Schwartz

Keyword(s):

Protein Kinase ◽

Protein Phosphatase ◽

Protein Kinase B ◽

Protein Phosphatase 2A ◽

Local Activation ◽

Phosphatase 2A ◽

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Faculty Opinions recommendation of Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023795.367924 ◽

2006 ◽

Author(s):

Jonathan Millar

Keyword(s):

Sister Chromatid ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Sister Chromatid Cohesion ◽

Chromatid Cohesion ◽

Phosphatase 2A ◽

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