Activation of Endogenous Nitric Oxide Synthase Coupled with Methacholine-Induced Exocytosis in Rat Parotid Acinar Cells

2002 ◽  
Vol 301 (1) ◽  
pp. 355-363 ◽  
Author(s):  
Yasuko Ishikawa ◽  
Hirokazu Iida ◽  
Mariusz T. Skowronski ◽  
Hajime Ishida
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Acinar Cells ◽  
Parotid Acinar Cells ◽  
Endogenous Nitric Oxide ◽  
Rat Parotid ◽  
Oxide Synthase

scholarly journals Modulation of Opioid Actions by Nitric Oxide Signaling

2009 ◽  
Vol 110 (1) ◽  
pp. 166-181 ◽  
Author(s):  
Noboru Toda ◽  
Shiroh Kishioka ◽  
Yoshio Hatano ◽  
Hiroshi Toda ◽  
David S. Warner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Glial Cells ◽  
Withdrawal Syndrome ◽  
Therapeutic Agents ◽  
Nitric Oxide Signaling ◽  
Endogenous Nitric Oxide ◽  
Oxide Synthase ◽  
New Strategies

Nitric oxide (NO) plays pivotal roles in controlling physiological functions, participates in pathophysiological intervention, and is involved in mechanisms underlying beneficial or untoward actions of therapeutic agents. Endogenous nitric oxide is formed by three isoforms of nitric oxide synthase: endothelial, neurogenic and inducible. The former two are constitutively present mainly in the endothelium and nervous system, respectively, and the latter one is induced by lipopolysaccharides or cytokines mainly in mitochondria and glial cells. Constitutively formed nitric oxide modulates the actions of morphine and related analgesics by either enhancing or reducing antinociception. Tolerance to and dependence on morphine or its withdrawal syndrome are likely prevented by nitric oxide synthase inhibition. Information concerning modulation of morphine actions by nitric oxide is undoubtedly useful in establishing new strategies for efficient antinociceptive treatment and for minimizing noxious and unintended reactions.

scholarly journals Endogenous Nitric Oxide Synthase Inhibitor in Human Atheromatous Lesion

1997 ◽  
Vol 75 ◽  
pp. 55
Author(s):  
Hidehiro Matsuoka ◽  
Hiroshi Miyazaki ◽  
Seiya Katoh ◽  
Hideo Yasukawa ◽  
Michiaki Usui ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase Inhibitor ◽  
Endogenous Nitric Oxide ◽  
Synthase Inhibitor ◽  
Oxide Synthase
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