scholarly journals Modulation of Opioid Actions by Nitric Oxide Signaling

2009 ◽  
Vol 110 (1) ◽  
pp. 166-181 ◽  
Author(s):  
Noboru Toda ◽  
Shiroh Kishioka ◽  
Yoshio Hatano ◽  
Hiroshi Toda ◽  
David S. Warner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Glial Cells ◽  
Withdrawal Syndrome ◽  
Therapeutic Agents ◽  
Nitric Oxide Signaling ◽  
Endogenous Nitric Oxide ◽  
Oxide Synthase ◽  
New Strategies

Nitric oxide (NO) plays pivotal roles in controlling physiological functions, participates in pathophysiological intervention, and is involved in mechanisms underlying beneficial or untoward actions of therapeutic agents. Endogenous nitric oxide is formed by three isoforms of nitric oxide synthase: endothelial, neurogenic and inducible. The former two are constitutively present mainly in the endothelium and nervous system, respectively, and the latter one is induced by lipopolysaccharides or cytokines mainly in mitochondria and glial cells. Constitutively formed nitric oxide modulates the actions of morphine and related analgesics by either enhancing or reducing antinociception. Tolerance to and dependence on morphine or its withdrawal syndrome are likely prevented by nitric oxide synthase inhibition. Information concerning modulation of morphine actions by nitric oxide is undoubtedly useful in establishing new strategies for efficient antinociceptive treatment and for minimizing noxious and unintended reactions.

Inhibitory effect of melatonin on nitric oxide synthase in rat enteric nervous system

2001 ◽  
Vol 120 (5) ◽  
pp. A176-A176
Author(s):  
P KOPPITZ ◽  
M STORR ◽  
D SAUR ◽  
M KURJAK ◽  
H ALLESCHER
Keyword(s):  
Nitric Oxide ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Enteric Nervous System ◽  
Inhibitory Effect ◽  
Oxide Synthase

Nitric Oxide Synthase Expression in Glial Cells: Suppression by Tyrosine Kinase Inhibitors

2002 ◽  
Vol 62 (2) ◽  
pp. 811-814 ◽  
Author(s):  
Douglas L. Feinstein ◽  
Elena Galea ◽  
Jennifer Cermak ◽  
Punita Chugh ◽  
Liubov Lyandvert ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Glial Cells ◽  
Kinase Inhibitors ◽  
Oxide Synthase

Endothelin enhances lipopolysaccharide-induced expression of inducible nitric oxide synthase in rat glial cells

1997 ◽  
Vol 339 (2-3) ◽  
pp. 253-260 ◽  
Author(s):  
Haruko Oda ◽  
Toshihiko Murayama ◽  
Yukio Sasaki ◽  
Toshikazu Okada ◽  
Yasuyuki Nomura
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Glial Cells ◽  
Inducible Nitric Oxide Synthase ◽  
Induced Expression ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Transplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Conor J. McCann ◽  
Julie E. Cooper ◽  
Dipa Natarajan ◽  
Benjamin Jevans ◽  
Laura E. Burnett ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Enteric Nervous System ◽  
Deficient Mouse ◽  
Mouse Colon ◽  
Oxide Synthase

NG-Methyl-L-Arginine, an Inhibitor of Nitric Oxide Synthase, Affects the Central Nervous System to Produce Peripheral Hyperglycemia in Conscious Rats

1997 ◽  
Vol 66 (2) ◽  
pp. 136-144 ◽  
Author(s):  
Kazumasa Uemura ◽  
Tatsuo Tamagawa ◽  
Yi Chen ◽  
Noriki Maeda ◽  
Shuko Yoshioka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Central Nervous System ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Conscious Rats ◽  
The Central Nervous System ◽  
Oxide Synthase
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