α2A Adrenergic Receptor Activation Inhibits Epileptiform Activity in the Rat Hippocampal CA3 Region

2007 ◽  
Vol 71 (6) ◽  
pp. 1572-1581 ◽  
Author(s):  
Chris W. D. Jurgens ◽  
Hana M. Hammad ◽  
Jessica A. Lichter ◽  
Sarah J. Boese ◽  
Brian W. Nelson ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Epileptiform Activity ◽  
Receptor Activation ◽  
Hippocampal Ca3 ◽  
Ca3 Region

scholarly journals Regulator of G Protein Signaling Protein Suppression of Gαo Protein-Mediated α2A Adrenergic Receptor Inhibition of Mouse Hippocampal CA3 Epileptiform Activity

2009 ◽  
Vol 75 (5) ◽  
pp. 1222-1230 ◽  
Author(s):  
Brianna L. Goldenstein ◽  
Brian W. Nelson ◽  
Ke Xu ◽  
Elizabeth J. Luger ◽  
Jacquline A. Pribula ◽  
...  
Keyword(s):  
G Protein ◽  
Adrenergic Receptor ◽  
Epileptiform Activity ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Signaling Protein ◽  
Receptor Inhibition ◽  
Hippocampal Ca3

scholarly journals Gαo proteins regulate the α2A adrenergic receptor‐mediated inhibitory effects of epinephrine in the mouse hippocampal CA3 region

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Brian W Nelson ◽  
Ke Xu ◽  
Brianna Goldenstein ◽  
Jacquline Pribula ◽  
Elizabeth Luger ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Inhibitory Effects ◽  
Hippocampal Ca3 ◽  
Ca3 Region

scholarly journals RGS7 Protein Suppression of Gao Protein‐Mediated α2A‐Adrenergic Receptor Inhibition of Mouse Hippocampal CA3 Epileptiform Activity

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Brian William Nelson ◽  
Brianna Goldenstein ◽  
Ke Xu ◽  
Elizabeth Luger ◽  
Jenna Wald ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Epileptiform Activity ◽  
Receptor Inhibition ◽  
Hippocampal Ca3

Phasic GABAA-receptor activation is required to suppress epileptiform activity in the CA3 region of the immature rat hippocampus

Epilepsia ◽  
2012 ◽  
Vol 53 (5) ◽  
pp. 888-896 ◽  
Author(s):  
Sergey N. Kolbaev ◽  
Salim Sharopov ◽  
Paul W. Dierkes ◽  
Heiko J. Luhmann ◽  
Werner Kilb
Keyword(s):  
Gabaa Receptor ◽  
Epileptiform Activity ◽  
Receptor Activation ◽  
Rat Hippocampus ◽  
Immature Rat ◽  
Ca3 Region

scholarly journals Pharmacological characterization of the α 2 adrenergic receptor inhibiting mouse hippocampal CA3 epileptiform activity

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Brian Nelson ◽  
Brianna Goldenstein ◽  
Ke Xu ◽  
Elizabeth Luger ◽  
Jacquline Pribula ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Epileptiform Activity ◽  
Pharmacological Characterization ◽  
Hippocampal Ca3

Simulations of epileptiform activity in the hippocampal CA3 region in vitro

Hippocampus ◽  
1994 ◽  
Vol 4 (3) ◽  
pp. 281-285 ◽  
Author(s):  
Roger D. Traub ◽  
John G. R. Jefferys
Keyword(s):  
Epileptiform Activity ◽  
Hippocampal Ca3 ◽  
Ca3 Region

scholarly journals Alpha‐2A adrenergic receptor activation inhibits rat hippocampal CA3 network activity

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Kylie Davis ◽  
Jessica Lichter ◽  
Brian Nelson ◽  
Brianna Goldenstein ◽  
Sarah Boese ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Activation ◽  
Network Activity ◽  
Hippocampal Ca3

Prenatal Morphine Exposure Attenuates the Maintenance of Late LTP in Lateral Perforant Path Projections to the Dentate Gyrus and the CA3 Region In Vivo

2008 ◽  
Vol 99 (3) ◽  
pp. 1235-1242 ◽  
Author(s):  
D. M. Villarreal ◽  
B. Derrick ◽  
I. Vathy
Keyword(s):  
Dentate Gyrus ◽  
Opioid Receptor ◽  
Prenatal Exposure ◽  
Opioid Receptors ◽  
Opioid Peptides ◽  
Long Term Potentiation ◽  
Receptor Activation ◽  
Perforant Path ◽  
Hippocampal Ca3 ◽  
Ca3 Region

Previously we reported that prenatal exposure to morphine twice daily during gestation decreases proenkephalin levels in adult progeny within the brain, including the dentate gyrus, and alters μ and δ opioid receptors in the hippocampal CA3 region. The lateral aspect of the perforant path contains and releases enkephalin-derived opioid peptides, and induction of long-term potentiation (LTP) in lateral perforant path projections to both the dentate gyrus and the hippocampal CA3 region is blocked by antagonists of opioid receptors. Thus LTP induction at these synapses involves opioid receptor activation mediated by the release of proenkephalin-derived opioid peptides with lateral perforant path activation. Here we show in adult behaving animals, neither LTP induction nor the early phase of LTP (E-LTP) maintenance is altered by prenatal morphine exposure in the lateral perforant path projections to the dentate gyrus and the CA3 region. However, maintenance and longevity of late LTP (L-LTP), as reflected in the magnitude of LTP over days, was attenuated in animals prenatally exposed to morphine. In contrast, in medial perforant path projections to the dentate gyrus and CA3 region, both LTP induction and the maintenance of E- and L-LTP were unaffected by prenatal morphine treatment. Thus a brief prenatal exposure to the opiate morphine produces sustained, and possibly permanent, alterations in L-LTP in the opioidergic lateral perforant path projection. This suggests that prenatal morphine exposure disrupts LTP via disruption of opioid mechanisms involved in LTP maintenance or via disruption of opioid receptor activation during LTP induction, which can subsequently alter LTP maintenance.

scholarly journals Alpha‐2A adrenergic receptor activation inhibits rat hippocampal CA3 network activity

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jacquline A Pribula ◽  
Sarah Boese ◽  
Ke Xu ◽  
Brian Nelson ◽  
Brianna Goldenstein ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Activation ◽  
Network Activity ◽  
Hippocampal Ca3
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