Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284

Deborah L. Smith; Jennifer E. Davoren; Jeremy R. Edgerton; John T. Lazzaro; Che-Wah Lee; Sarah Neal; Lei Zhang; Sarah Grimwood

doi:10.1124/mol.116.104737

Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284

Molecular Pharmacology ◽

10.1124/mol.116.104737 ◽

2016 ◽

Vol 90 (3) ◽

pp. 177-187 ◽

Cited By ~ 6

Author(s):

Deborah L. Smith ◽

Jennifer E. Davoren ◽

Jeremy R. Edgerton ◽

John T. Lazzaro ◽

Che-Wah Lee ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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P2-317: Suvn-i1312004, a novel M1 muscarinic acetylcholine receptor-positive allosteric modulator: Potential for the treatment of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.859 ◽

2015 ◽

Vol 11 (7S_Part_13) ◽

pp. P615-P616

Author(s):

Renny Abraham ◽

Ramkumar Subramanian ◽

Rajesh Babu Medapati ◽

Ravirala Venkateshwarlu ◽

Sumanth Yathavakilla ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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P1-399: SUVN-I1307014: NOVEL M1 MUSCARINIC ACETYLCHOLINE RECEPTOR POSITIVE ALLOSTERIC MODULATOR FOR POTENTIAL TREATMENT OF ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.05.641 ◽

2014 ◽

Vol 10 ◽

pp. P460-P460

Author(s):

Renny Abraham ◽

Medapati Rajesh Babu ◽

Rama Lakshmana ◽

Karthik Gadi ◽

Venkateshwarlu Ravirala ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Potential Treatment ◽

Positive Allosteric Modulator ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01562 ◽

2015 ◽

Vol 59 (1) ◽

pp. 388-409 ◽

Cited By ~ 27

Author(s):

Shailesh N. Mistry ◽

Manuela Jörg ◽

Herman Lim ◽

Natalie B. Vinh ◽

Patrick M. Sexton ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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A M1 muscarinic acetylcholine receptor positive allosteric modulator improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice

British Journal of Pharmacology ◽

10.1111/bph.15750 ◽

2021 ◽

Author(s):

Khaled S. Abd‐Elrahman ◽

Shaarika Sarasija ◽

Tash‐Lynn L. Colson ◽

Stephen S. G. Ferguson

Keyword(s):

Acetylcholine Receptor ◽

Cognitive Deficits ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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Pharmacological characterization of M1 muscarinic acetylcholine receptor-mediated Gq activation in rat cerebral cortical and hippocampal membranes

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-013-0887-7 ◽

2013 ◽

Vol 386 (11) ◽

pp. 937-947 ◽

Cited By ~ 11

Author(s):

Yuji Odagaki ◽

Masakazu Kinoshita ◽

Ryoichi Toyoshima

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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Pharmacological Characterization of LY593093, an M1 Muscarinic Acetylcholine Receptor-Selective Partial Orthosteric Agonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.111.182063 ◽

2011 ◽

Vol 338 (2) ◽

pp. 622-632 ◽

Cited By ~ 19

Author(s):

Marla L. Watt ◽

Douglas A. Schober ◽

Stephen Hitchcock ◽

Bin Liu ◽

Amy K. Chesterfield ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated Galpha(q) signalling in patients with psychiatric disorders

10.26226/morressier.5b68175eb56e9b005965c3a3 ◽

2018 ◽

Author(s):

Yuji Odagaki

Keyword(s):

Psychiatric Disorders ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts

Pharmacological Reports ◽

10.1007/s43440-021-00248-w ◽

2021 ◽

Author(s):

Yuji Odagaki ◽

Masakazu Kinoshita ◽

J. Javier Meana ◽

Luis F. Callado ◽

Jesús A. García-Sevilla

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Dorsolateral Prefrontal Cortex ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

Dorsolateral Prefrontal ◽

Opiate Addicts ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.137968 ◽

2008 ◽

Vol 325 (3) ◽

pp. 869-874 ◽

Cited By ~ 20

Author(s):

Hasib Salah-Uddin ◽

David R. Thomas ◽

Ceri H. Davies ◽

Jim J. Hagan ◽

Martyn D. Wood ◽

...

Keyword(s):

Human Brain ◽

Brain Tissue ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Human Brain Tissue ◽

Postmortem Human Brain ◽

Protein Coupling ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand‐binding affinity and signal transduction

The FASEB Journal ◽

10.1096/fj.201800936r ◽

2018 ◽

Vol 33 (3) ◽

pp. 3237-3251 ◽

Cited By ~ 3

Author(s):

Jianrong Xu ◽

Panpan Tan ◽

Hui Li ◽

Yongyao Cui ◽

Yu Qiu ◽

...

Keyword(s):

Signal Transduction ◽

Ligand Binding ◽

Binding Affinity ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

Download Full-text