A Wake-Up Call in the Fight Against Sleeping Sickness

2021 ◽  
Keyword(s):  
Sleeping Sickness

The Sleeping Sickness

1904 ◽  
Vol 57 (1469supp) ◽  
pp. 23540-23541
Keyword(s):  
Sleeping Sickness

scholarly journals Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection

2016 ◽  
Vol 9 (2) ◽  
pp. 381-393 ◽  
Author(s):  
Joshua B. Richardson ◽  
Benjamin Evans ◽  
Patient P. Pyana ◽  
Nick Van Reet ◽  
Mark Sistrom ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Sleeping Sickness ◽  
Whole Genome

Sleeping sickness: An agent-based model approach

2021 ◽  
pp. 126282
Author(s):  
Matheus M.G. Correia ◽  
João V.M. Barboza ◽  
Aquino L. Espíndola
Keyword(s):  
Sleeping Sickness ◽  
Agent Based Model ◽  
Agent Based ◽  
Model Approach

scholarly journals Implications of seasonal variations, host and vector migration on spatial spread of sleeping sickness: Insights from a mathematical model

2021 ◽  
Vol 24 ◽  
pp. 100570
Author(s):  
Mlyashimbi Helikumi ◽  
Paride O. Lolika ◽  
Steady Mushayabasa
Keyword(s):  
Mathematical Model ◽  
Seasonal Variations ◽  
Sleeping Sickness ◽  
Spatial Spread

scholarly journals Quantifying the Burden of Rhodesiense Sleeping Sickness in Urambo District, Tanzania

2010 ◽  
Vol 4 (11) ◽  
pp. e868 ◽  
Author(s):  
Lucas E. Matemba ◽  
Eric M. Fèvre ◽  
Stafford N. Kibona ◽  
Kim Picozzi ◽  
Sarah Cleaveland ◽  
...  
Keyword(s):  
Sleeping Sickness

scholarly journals Safety and Efficacy of the 10-Day Melarsoprol Schedule for the Treatment of Second Stage Rhodesiense Sleeping Sickness

2012 ◽  
Vol 6 (8) ◽  
pp. e1695 ◽  
Author(s):  
Irene Kuepfer ◽  
Caecilia Schmid ◽  
Mpairwe Allan ◽  
Andrew Edielu ◽  
Emma P. Haary ◽  
...  
Keyword(s):  
Sleeping Sickness ◽  
Safety And Efficacy ◽  
Second Stage

scholarly journals Targeting the Variable Surface of African Trypanosomes with Variant Surface Glycoprotein-Specific, Serum-Stable RNA Aptamers

2003 ◽  
Vol 2 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Mihaela Lorger ◽  
Markus Engstler ◽  
Matthias Homann ◽  
H. Ulrich Göringer
Keyword(s):  
Antigenic Variation ◽  
Sleeping Sickness ◽  
Rna Aptamers ◽  
Surface Glycoprotein ◽  
Variant Surface Glycoprotein ◽  
Parasite Protein ◽  
African Trypanosomes ◽  
Variable Surface ◽  
New Strategy

ABSTRACT African trypanosomes cause sleeping sickness in humans and Nagana in cattle. The parasites multiply in the blood and escape the immune response of the infected host by antigenic variation. Antigenic variation is characterized by a periodic change of the parasite protein surface, which consists of a variant glycoprotein known as variant surface glycoprotein (VSG). Using a SELEX (systematic evolution of ligands by exponential enrichment) approach, we report the selection of small, serum-stable RNAs, so-called aptamers, that bind to VSGs with subnanomolar affinity. The RNAs are able to recognize different VSG variants and bind to the surface of live trypanosomes. Aptamers tethered to an antigenic side group are capable of directing antibodies to the surface of the parasite in vitro. In this manner, the RNAs might provide a new strategy for a therapeutic intervention to fight sleeping sickness.

scholarly journals Costs Of Using “Tiny Targets” to Control Glossina fuscipes fuscipes, a Vector of Gambiense Sleeping Sickness in Arua District of Uganda

2015 ◽  
Vol 9 (3) ◽  
pp. e0003624 ◽  
Author(s):  
Alexandra P. M. Shaw ◽  
Inaki Tirados ◽  
Clement T. N. Mangwiro ◽  
Johan Esterhuizen ◽  
Michael J. Lehane ◽  
...  
Keyword(s):  
Sleeping Sickness ◽  
Glossina Fuscipes Fuscipes
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