DNA repair amplifies transcriptional noise

Science ◽  
2021 ◽  
Vol 373 (6557) ◽  
pp. 866.10-868
Author(s):  
L. Bryan Ray
Keyword(s):  
Dna Repair ◽  
Transcriptional Noise

A DNA-repair pathway can affect transcriptional noise to promote cell fate transitions

Science ◽  
2021 ◽  
pp. eabc6506
Author(s):  
Ravi V. Desai ◽  
Xinyue Chen ◽  
Benjamin Martin ◽  
Sonali Chaturvedi ◽  
Dong Woo Hwang ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cell Fate ◽  
Excision Repair ◽  
Dna Supercoiling ◽  
Cellular Reprogramming ◽  
Transcriptional Noise ◽  
Expression Noise ◽  
Dna Base ◽  
Base Modifications ◽  
Base Excision

Stochastic fluctuations in gene expression (‘noise’) are often considered detrimental, but fluctuations can also be exploited for benefit (e.g., dither). We show here that DNA base-excision repair amplifies transcriptional noise to facilitate cellular reprogramming. Specifically, the DNA-repair protein Apex1, which recognizes both naturally occurring and unnatural base modifications, amplifies expression noise while homeostatically maintaining mean-expression levels. This amplified expression noise originates from shorter duration, higher intensity, transcriptional bursts generated by Apex1-mediated DNA supercoiling. The remodeling of DNA topology first impedes and then accelerates transcription to maintain mean levels. This mechanism, which we term Discordant Transcription through Repair (DiThR; pronounced /’dither’/), potentiates cellular reprogramming and differentiation. Our study reveals a potential functional role for transcriptional fluctuations mediated by DNA base modifications in embryonic development and disease.

259: Dna-Repair Genetic Polymorphisms and Prostate Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Prostate Cancer Risk

983: Bladder Cancer Predisposition: A Pathway-Based Approach to DNA Repair and Cell Cycle Control Genes

2006 ◽  
Vol 175 (4S) ◽  
pp. 317-317
Author(s):  
Xifeng Wu ◽  
Jian Gu ◽  
H. Barton Grossman ◽  
Christopher I. Amos ◽  
Carol Etzel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Bladder Cancer ◽  
Dna Repair ◽  
Cell Cycle Control ◽  
Cancer Predisposition

Drugs Impair Keratinocyte DNA Repair in Culture

2005 ◽  
Vol 36 (7) ◽  
pp. 42
Author(s):  
PATRICE WENDLING
Keyword(s):  
Dna Repair

DNA Repair

2019 ◽  
Keyword(s):  
Dna Repair

DNA Repair and Transcription in Human Premature Aging Disorders

1998 ◽  
Vol 3 (1) ◽  
pp. 11-13 ◽  
Author(s):  
Vilhelm A Bohr ◽  
Grigoiy Dianov ◽  
Adayabalam Balajee ◽  
Alfred May ◽  
David K Orren
Keyword(s):  
Dna Repair ◽  
Premature Aging

DNA repair: Finding a surprising partner

Nature China ◽  
2007 ◽  
Author(s):  
Dangsheng Li
Keyword(s):  
Dna Repair

Tobacco giant sponsors work on DNA repair

Nature ◽  
2006 ◽  
Keyword(s):  
Dna Repair

DNA repair: all due to SUMO

2012 ◽  
Author(s):  
Edward Duca
Keyword(s):  
Dna Repair
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