Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling

2021 ◽  
Vol 14 (714) ◽  
Author(s):  
Mayumi Mori ◽  
Julie Ruer-Laventie ◽  
Wandrille Duchemin ◽  
Philippe Demougin ◽  
Tohnyui Ndinyanka Fabrice ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Caspase 8 ◽  
T Cell Survival

scholarly journals The c-FLIPLCleavage Product p43FLIP Promotes Activation of Extracellular Signal-regulated Kinase (ERK), Nuclear Factor κB (NF-κB), and Caspase-8 and T Cell Survival

2013 ◽  
Vol 289 (2) ◽  
pp. 1183-1191 ◽  
Author(s):  
Andreas Koenig ◽  
Iwona A. Buskiewicz ◽  
Karen A. Fortner ◽  
Jennifer Q. Russell ◽  
Tomoko Asaoka ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Nuclear Factor Κb ◽  
Caspase 8 ◽  
Nuclear Factor ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
T Cell Survival

scholarly journals Cellular FLICE-inhibitory protein is required for T cell survival and cycling

2005 ◽  
Vol 202 (3) ◽  
pp. 405-413 ◽  
Author(s):  
Hien Chau ◽  
Veronica Wong ◽  
Nien-Jung Chen ◽  
Huey-Lan Huang ◽  
Wen-Jye Lin ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Survival ◽  
Cell Function ◽  
Embryonic Stem ◽  
Underlying Mechanism ◽  
Caspase 8 ◽  
Death Domain ◽  
Inhibitory Protein ◽  
T Cell Survival

Fas-associated death domain (FADD) and caspase-8 are key signal transducers for death receptor–induced apoptosis, whereas cellular FLICE-inhibitory protein (cFLIP) antagonizes this process. Interestingly, FADD and caspase-8 also play a role in T cell development and T cell receptor (TCR)–mediated proliferative responses. To investigate the underlying mechanism, we generated cFLIP-deficient T cells by reconstituting Rag−/− blastocysts with cFLIP-deficient embryonic stem cells. These Rag chimeric mutant mice (rcFLIP−/−) had severely reduced numbers of T cells in the thymus, lymph nodes, and spleen, although mature T lymphocytes did develop. Similar to FADD- or caspase-8–deficient cells, rcFLIP−/− T cells were impaired in proliferation in response to TCR stimulation. Further investigation revealed that cFLIP is required for T cell survival, as well as T cell cycling in response to TCR stimulation. Interestingly, some signaling pathways from the TCR complex appeared competent, as CD3 plus CD28 cross-linking was capable of activating the ERK pathway in rcFLIP−/− T cells. We demonstrate an essential role for cFLIP in T cell function.

scholarly journals Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion

2010 ◽  
Vol 18 (1) ◽  
pp. 90-98 ◽  
Author(s):  
S Leverrier ◽  
G S Salvesen ◽  
C M Walsh
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Clonal Expansion ◽  
Caspase 8 ◽  
Single Chain ◽  
T Cell Survival
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