A Generalized Linear-Quadratic Model for Radiosurgery, Stereotactic Body Radiation Therapy, and High-Dose Rate Brachytherapy

2010 ◽  
Vol 2 (39) ◽  
pp. 39ra48-39ra48 ◽  
Author(s):  
J. Z. Wang ◽  
Z. Huang ◽  
S. S. Lo ◽  
W. T. C. Yuh ◽  
N. A. Mayr
Keyword(s):  
Radiation Therapy ◽  
Dose Rate ◽  
Stereotactic Body Radiation Therapy ◽  
High Dose Rate ◽  
Quadratic Model ◽  
High Dose ◽  
Linear Quadratic ◽  
High Dose Rate Brachytherapy ◽  
Stereotactic Body Radiation ◽  
Linear Quadratic Model

scholarly journals Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response

2016 ◽  
Vol 15 (6) ◽  
pp. 759-765 ◽  
Author(s):  
Antonio Pontoriero ◽  
Giuseppe Iatì ◽  
Dario Aiello ◽  
Stefano Pergolizzi
Keyword(s):  
Radiation Therapy ◽  
Dose Rate ◽  
Stereotactic Body Radiation Therapy ◽  
Radiation Therapy Oncology Group ◽  
High Dose Rate ◽  
High Dose ◽  
European Organization ◽  
Recurrent Cervical Cancer ◽  
Cervical Cancers ◽  
Stereotactic Body Radiation

Aim: To evaluate the role of stereotactic body radiation therapy in the retreatment of locally recurrent cervical cancers. Brachytherapy is the main choice to treat gynecologic cancers. Methods: Patients with recurrent cervical cancer, previously submitted to radiotherapy, were treated with stereotactic body radiation therapy using a CyberKnife system (Accuray Incorporated, Sunnyvale, California) with a fiducial tracking system. Results: From August 2011 to October 2014, 5 patients have been treated. Median age was 81 years (range, 70-84 years). Two patients were diagnosed with adenocarcinoma endometrioid and 3 with squamous cell carcinoma. Toxicity was scored according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. After a median follow-up of 12 months (range, 8-34 months), no severe (>grade 3) acute/late genitourinary or low gastrointestinal toxicity was observed. Conclusion: Our preliminary results of stereotactic body radiation therapy “simulating” high dose rate for recurrent cervical cancers confirm a minimal toxicity and an optimal outcome. The stereotactic body radiation therapy is an alternative to high dose rate brachytherapy for gynecologic tumors.

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