Nano-antidotes for drug overdose and poisoning

2015 ◽  
Vol 7 (290) ◽  
pp. 290ps14-290ps14 ◽  
Author(s):  
Vincent Forster ◽  
Jean-Christophe Leroux
Keyword(s):  
United States ◽  
Drug Overdose ◽  
Safety Profile ◽  
Recent Progress ◽  
The United States ◽  
Proof Of Concept ◽  
Medical Needs ◽  
Higher Doses ◽  
Unmet Medical Needs

The number of intoxications from xenobiotics—natural or synthetic foreign chemicals, or substances given in higher doses than typically present in humans—has risen tremendously in the last decade, placing poisoning as the leading external cause of death in the United States. This epidemic has fostered the development of antidotal nanomedicines, which we call “nano-antidotes,” capable of efficiently neutralizing offending compounds in situ. Although prototype nano-antidotes have shown efficacy in proof-of-concept studies, the gap to clinical translation can only be filled if issues such as the clinical relevance of intoxication models and the safety profile of nano-antidotes are properly addressed. As the unmet medical needs in resuscitative care call for better treatments, this Perspective critically reviews the recent progress in antidotal medicine and emerging nanotechnologies.

Perceived Discrimination and Increased Odds of Unmet Medical Needs Among US Children

2021 ◽  
pp. 002073142199708
Author(s):  
Sze Yan Liu ◽  
Roman Pabayo ◽  
Peter Muennig
Keyword(s):  
United States ◽  
Perceived Discrimination ◽  
The United States ◽  
Exact Matching ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Model Estimate ◽  
Medical Needs ◽  
Us Children ◽  
Unmet Medical Needs

Our study examines the association between perceived discrimination due to race and unmet medical needs among a nationally representative sample of children in the United States. We used data from the 2016-2017 National Survey of Children's Health, a population-based cross-sectional survey of randomly selected parents or guardians in the United States. We compared results from the coarsened exact matching (CEM) method and survey-weighted logistic regression to assess the robustness of the results. Using self-reported measures from caregivers, we find that ∼2.7% of US children have experienced racial discrimination with prevalence varying significantly by race. While <1% of non-Hispanic whites have experienced some measure of racism, this increases to 8.8% among non-Hispanic blacks. Perceived discrimination was associated with significantly greater odds of unmet medical needs in the adjusted, survey-weighted multivariate-adjusted model (adjusted odds ratio [OR] = 2.4 and 95% confidence interval [CI] = 1.2, 4.9) as well as in the CEM-model estimate (OR = 2.8 and 95% CI = 1.8, 4.0). Children who have experienced perceived discrimination had higher odds of unmet medical needs. Awareness of discrimination among children may help inform future intervention development that addresses unmet medical needs during childhood.

scholarly journals The Unmet Medical Needs of Correctional Populations in the United States

2012 ◽  
Vol 104 (11-12) ◽  
pp. 487-492 ◽  
Author(s):  
Karen L. Cropsey ◽  
Ingrid A. Binswanger ◽  
C. Brendan Clark ◽  
Faye S. Taxman
Keyword(s):  
United States ◽  
The United States ◽  
Medical Needs ◽  
Unmet Medical Needs

The Special Perils of Being Old and Sick in Prison

2020 ◽  
Vol 32 (5) ◽  
pp. 276-284
Author(s):  
William J. Jefferson
Keyword(s):  
United States ◽  
Health Care ◽  
Medical Care ◽  
Health Care Providers ◽  
The United States ◽  
United States Constitution ◽  
Care Providers ◽  
Medical Practitioners ◽  
Medical Needs ◽  
Access To Medical Care

The United States Supreme Court declared in 1976 that deliberate indifference to the serious medical needs of prisoners constitutes the unnecessary and wanton infliction of pain…proscribed by the Eighth Amendment. It matters not whether the indifference is manifested by prison doctors in their response to the prisoner’s needs or by prison guards intentionally denying or delaying access to medical care or intentionally interfering with treatment once prescribed—adequate prisoner medical care is required by the United States Constitution. My incarceration for four years at the Oakdale Satellite Prison Camp, a chronic health care level camp, gives me the perspective to challenge the generally promoted claim of the Bureau of Federal Prisons that it provides decent medical care by competent and caring medical practitioners to chronically unhealthy elderly prisoners. The same observation, to a slightly lesser extent, could be made with respect to deficiencies in the delivery of health care to prisoners of all ages, as it is all significantly deficient in access, competencies, courtesies and treatments extended by prison health care providers at every level of care, without regard to age. However, the frailer the prisoner, the more dangerous these health care deficiencies are to his health and, therefore, I believe, warrant separate attention. This paper uses first-hand experiences of elderly prisoners to dismantle the tale that prisoner healthcare meets constitutional standards.

scholarly journals International Arctic Systems for Observing the Atmosphere: An International Polar Year Legacy Consortium

2016 ◽  
Vol 97 (6) ◽  
pp. 1033-1056 ◽  
Author(s):  
Taneil Uttal ◽  
Sandra Starkweather ◽  
James R. Drummond ◽  
Timo Vihma ◽  
Alexander P. Makshtas ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Satellite Observations ◽  
The Arctic ◽  
International Polar Year ◽  
Network Measurements ◽  
International Polar ◽  
In Situ Observations ◽  
Arctic Atmosphere

Abstract International Arctic Systems for Observing the Atmosphere (IASOA) activities and partnerships were initiated as a part of the 2007–09 International Polar Year (IPY) and are expected to continue for many decades as a legacy program. The IASOA focus is on coordinating intensive measurements of the Arctic atmosphere collected in the United States, Canada, Russia, Norway, Finland, and Greenland to create synthesis science that leads to an understanding of why and not just how the Arctic atmosphere is evolving. The IASOA premise is that there are limitations with Arctic modeling and satellite observations that can only be addressed with boots-on-the-ground, in situ observations and that the potential of combining individual station and network measurements into an integrated observing system is tremendous. The IASOA vision is that by further integrating with other network observing programs focusing on hydrology, glaciology, oceanography, terrestrial, and biological systems it will be possible to understand the mechanisms of the entire Arctic system, perhaps well enough for humans to mitigate undesirable variations and adapt to inevitable change.

scholarly journals What Is Driving the Drug Overdose Epidemic in the United States?

2020 ◽  
Vol 61 (3) ◽  
pp. 274-274
Author(s):  
Ryan P. Thombs ◽  
Dennis L. Thombs ◽  
Andrew K. Jorgenson ◽  
Taylor Harris Braswell
Keyword(s):  
United States ◽  
Drug Overdose ◽  
The United States
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