The Molecular Genetics of Mycolic Acid Biosynthesis

2015 ◽  
pp. 611-631
Author(s):  
Jakub Pawełczyk ◽  
Laurent Kremer
Keyword(s):  
Molecular Genetics ◽  
Mycolic Acid ◽  
Acid Biosynthesis

scholarly journals A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

2003 ◽  
Vol 101 (1) ◽  
pp. 314-319 ◽  
Author(s):  
D. Portevin ◽  
C. de Sousa-D'Auria ◽  
C. Houssin ◽  
C. Grimaldi ◽  
M. Chami ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Mycolic Acid ◽  
Acid Biosynthesis

scholarly journals Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy

2003 ◽  
Vol 49 (6) ◽  
pp. 1547-1563 ◽  
Author(s):  
Lian-Yong Gao ◽  
Francoise Laval ◽  
Elise H. Lawson ◽  
Richard K. Groger ◽  
Andy Woodruff ◽  
...  
Keyword(s):  
Cell Wall ◽  
Intracellular Survival ◽  
Mycolic Acid ◽  
Acid Biosynthesis

scholarly journals Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes ofMycobacterium tuberculosis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Eduard Baquero ◽  
Wiston Quiñones ◽  
Wellman Ribon ◽  
Maria Leonor Caldas ◽  
Ladys Sarmiento ◽  
...  
Keyword(s):  
Antimycobacterial Activity ◽  
Mycolic Acid ◽  
Mass Spectrometry Analysis ◽  
Ultrastructural Changes ◽  
Acid Biosynthesis ◽  
Spectrometry Analysis ◽  
Mycolic Acids ◽  
The World ◽  
Bacterial Morphology ◽  
Important Disease

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed againstMycobacterium tuberculosisH37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.

scholarly journals TheMycobacterium tuberculosisFAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development

2007 ◽  
Vol 64 (6) ◽  
pp. 1442-1454 ◽  
Author(s):  
Apoorva Bhatt ◽  
Virginie Molle ◽  
Gurdyal S. Besra ◽  
William R. Jacobs ◽  
Laurent Kremer
Keyword(s):  
Drug Development ◽  
Mycolic Acid ◽  
Acid Biosynthesis ◽  
Future Drug
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