Microbiology Spectrum
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Published By American Society For Microbiology

2165-0497, 2165-0497

Monika Opalek ◽  
Bogna Smug ◽  
Michael Doebeli ◽  
Dominika Wloch-Salamon

Nongenetic cell heterogeneity is present in glucose-starved yeast populations in the form of quiescent (Q) and nonquiescent (NQ) phenotypes. There is evidence that Q cells help the population survive long starvation.

Karen Kubo ◽  
Kaori Itto-Nakama ◽  
Shinsuke Ohnuki ◽  
Yoko Yashiroda ◽  
Sheena C. Li ◽  

Non- Candida albicans Candida species (NCAC) are on the rise as a cause of mycosis. Many antifungal drugs are less effective against NCAC, limiting the available therapeutic agents.

Ben Lin ◽  
Meng Wang ◽  
Renyuan Gao ◽  
Zhao Ye ◽  
Yifei Yu ◽  

Dysbiosis of gut microbiota is associated not only with intestinal disorders but also with numerous extraintestinal diseases. Growth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of GH and IGF-1, causing increased morbidity and mortality.

Erica L. Plummer ◽  
Kate Maddaford ◽  
Gerald L. Murray ◽  
Christopher K. Fairley ◽  
Shivani Pasricha ◽  

Given the role of the oral microbiota in human health, it is important to understand if and how external factors influence its composition. Mouthwash use is common in some populations, and the use of antiseptic mouthwash has been proposed as an alternative intervention to prevent gonorrhea transmission.

Yang Zhang ◽  
Liyan Zhou ◽  
Yan Liu ◽  
Xi Zhao ◽  
Xianqiang Lian ◽  

Cryptococcus neoformans and Cryptococcus gattii can cause cryptococcosis, which has a high mortality rate. To treat the disease, amphotericin B and fluconazole are often used in clinic.

Renru Han ◽  
Xuelin Yang ◽  
Yang Yang ◽  
Yan Guo ◽  
Dandan Yin ◽  

Multidrug-resistant Gram-negative bacteria, especially for extended-spectrum β-lactamases-producing and carbapenemase-producing Enterobacterales , are disseminating rapidly around the world. Treatment options for these infections are limited, which prompt the development of novel or combinational therapies to combat the infections caused by multidrug-resistant pathogens.

Zehong Cao ◽  
Guangjie Cheng

Over the past 2 decades, more than 20 new infectious diseases have emerged. Unfortunately, novel antimicrobial therapeutics are discovered at much lower rates.

Wassihun Wedajo Aragaw ◽  
Nicole Cotroneo ◽  
Suzanne Stokes ◽  
Michael Pucci ◽  
Ian Critchley ◽  

Clinical emergence of resistance to new antibiotics affects their utility. Characterization of in vitro resistance is a first step in the profiling of resistance properties of novel drug candidates.

Emmanuel Musisi ◽  
Abdul Sessolo ◽  
Sylvia Kaswabuli ◽  
Josephine Zawedde ◽  
Patrick Byanyima ◽  

This paper highlights the value of stool as a sample type for diagnosis of tuberculosis. While other studies have used DNA-based assays like the Xpert MTB/RIF and culture to detect Mycobacterium tuberculosis in stool, this is the first study that has applied TB-MBLA, an RNA-based assay, to quantify TB bacteria in stool.

Kayla A. Simanek ◽  
Isabelle R. Taylor ◽  
Erica K. Richael ◽  
Erica Lasek-Nesselquist ◽  
Bonnie L. Bassler ◽  

Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors. QS relies on the group-wide detection of molecules called autoinducers (AI).

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