scholarly journals Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide.

1979 ◽  
Vol 137 (3) ◽  
pp. 1165-1175 ◽  
Author(s):  
J W Foster ◽  
D M Kinney ◽  
A G Moat
Keyword(s):  
Salmonella Typhimurium ◽  
Nicotinamide Adenine Dinucleotide ◽  
Pyridine Nucleotide ◽  
Nicotinamide Adenine ◽  
Isolation And Characterization ◽  
Pyridine Nucleotide Cycle

Characterization of the nadR locus in Escherichia coli

1974 ◽  
Vol 20 (2) ◽  
pp. 205-209 ◽  
Author(s):  
Gerald J. Tritz
Keyword(s):  
Escherichia Coli ◽  
Genetic Control ◽  
Quinolinic Acid ◽  
Nicotinamide Adenine Dinucleotide ◽  
Pyridine Nucleotide ◽  
Nicotinamide Adenine ◽  
Positive Type ◽  
Pyridine Nucleotide Cycle

The biosynthesis of nicotinamide adenine dinucleotide (NAD) is under the genetic control of the nadR+ locus. The nadR+ allele is dominant to the nadR allele in transheterogenotes, indicating that the regulation is of the positive type. Mutants of the nadR type are unable to synthesize quinolinic acid; however, they do retain the ability to convert quinolinic acid into NAD and to recycle this NAD through the pyridine nucleotide cycle. Thus, the nadR+ locus regulates only genes involved in the biosynthesis of quinolinic acid.

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