scholarly journals Aspergillus Galactomannan Enzyme Immunoassay and Quantitative PCR for Diagnosis of Invasive Aspergillosis with Bronchoalveolar Lavage Fluid

2004 ◽  
Vol 42 (12) ◽  
pp. 5517-5522 ◽  
Author(s):  
B. Musher ◽  
D. Fredricks ◽  
W. Leisenring ◽  
S. A. Balajee ◽  
C. Smith ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Invasive Aspergillosis ◽  
Enzyme Immunoassay ◽  
Quantitative Pcr ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid

scholarly journals Performance Characteristics of the Platelia Aspergillus Enzyme Immunoassay for Detection of Aspergillus Galactomannan Antigen in Bronchoalveolar Lavage Fluid

2008 ◽  
Vol 15 (12) ◽  
pp. 1760-1763 ◽  
Author(s):  
S. Husain ◽  
C. J. Clancy ◽  
M. H. Nguyen ◽  
S. Swartzentruber ◽  
H. Leather ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Enzyme Immunoassay ◽  
Bronchoalveolar Lavage Fluid ◽  
Organ Transplant ◽  
Lavage Fluid ◽  
Solid Organ ◽  
Computed Tomographic ◽  
Transplant Patients ◽  
Galactomannan Antigen ◽  
Positive Results

ABSTRACT We have evaluated the Platelia Aspergillus enzyme immunoassay for detection of galactomannan in bronchoalveolar lavage (BAL) specimens in solid organ transplant patients with aspergillosis. The precision and reproducibility in serum or BAL to which galactomannan was added were similar. Sensitivity was 81.8% in patients with aspergillosis, and specificity was 95.8% in lung transplant patients who underwent BAL for surveillance for infection or rejection. Among transplant controls, positive results were more common in patients (i) who underwent diagnostic BAL performed for evaluation of symptoms or chest computed tomographic abnormalities, (ii) who had undergone lung transplantation, or (iii) who were colonized with Aspergillus. Galactomannan testing in BAL is useful for diagnosis of aspergillosis in transplant patients. The significance of positive results in patients without confirmed aspergillosis requires further evaluation.

Sign in / Sign up

Export Citation Format

Share Document