Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates.

1993 ◽  
Vol 67 (12) ◽  
pp. 7663-7667 ◽  
Author(s):  
D Pardi ◽  
J E Kaplan ◽  
J E Coligan ◽  
T M Folks ◽  
R B Lal
Virology ◽  
1995 ◽  
Vol 209 (2) ◽  
pp. 445-456 ◽  
Author(s):  
Vincenzo Ciminale ◽  
Donna M. D'Agostino ◽  
Lorenza Zotti ◽  
Genoveffa Franchini ◽  
Barbara K. Felber ◽  
...  

Gene ◽  
2006 ◽  
Vol 365 ◽  
pp. 119-124 ◽  
Author(s):  
Marco Turci ◽  
Maria Grazia Romanelli ◽  
Pamela Lorenzi ◽  
Paola Righi ◽  
Umberto Bertazzoni

1996 ◽  
Vol 70 (3) ◽  
pp. 1481-1492 ◽  
Author(s):  
N Eiraku ◽  
P Novoa ◽  
M da Costa Ferreira ◽  
C Monken ◽  
R Ishak ◽  
...  

1999 ◽  
Vol 15 (5) ◽  
pp. 407-417 ◽  
Author(s):  
Mirna Biglione ◽  
Oscar Vidan ◽  
Renaud Mahieux ◽  
Monica De Colombo ◽  
Maria De Los Angeles De Basualdo ◽  
...  

1998 ◽  
Vol 72 (5) ◽  
pp. 4327-4340 ◽  
Author(s):  
Anne-Mieke Vandamme ◽  
Marco Salemi ◽  
Marianne Van Brussel ◽  
Hsin-Fu Liu ◽  
Kristel Van Laethem ◽  
...  

ABSTRACT We identified a potential new subtype within human T-cell lymphotropic virus type 2 (HTLV-2), HTLV-2d, present in members of an isolated Efe Bambuti Pygmy tribe. Two of 23 Efe Pygmies were HTLV-2 seropositive, with HTLV-2 Western blot and enzyme-linked immunosorbent assay reactivities. From one of them the entire genome of the HTLV-2 strain Efe2 could be amplified and sequenced. In all gene regions analyzed, this strain was the most divergent HTLV-2 strain, differing by 2.4% (tax/rex) to 10.7% (long terminal repeat) from both subtypes HTLV-2a and HTLV-2b, yet major functional elements are conserved. The similarity between the HTLV-2 Efe2 Gag and Env proteins and the corresponding HTLV-2a and -2b proteins is consistent with the observed serological reactivity. In the proximal pX region, one of the two alternative splice acceptor sites is abolished in HTLV-2 Efe2. Another interesting feature of this potential new subtype is that it has a Tax protein of 344 amino acids (aa), which is intermediate in length between the HTLV-2a Tax protein (331 aa) and the HTLV-2b and -2c Tax proteins (356 aa) and similar to the simian T-cell lymphotropic virus type 2 (STLV-2) PP1664 Tax protein. Together these two findings suggest a different phenotype for the HTLV-2 Efe2 strain. Phylogenetic analyses confirmed that the Pygmy Efe2 strain potentially belonged to a new and quite divergent subtype, HTLV-2d. When the STLV-2 bonobo viruses PP1664 and PanP were used as an outgroup, it was clear that the Pygmy HTLV-2 Efe2 strain had the longest independent evolution and that HTLV-2 evolution is consistent with an African origin.


2006 ◽  
Vol 22 (10) ◽  
pp. 953-959 ◽  
Author(s):  
Simone Kashima ◽  
Luiz Carlos Alcantara ◽  
Osvaldo Massaiti Takayanagui ◽  
Marco Aurelio Valtas Cunha ◽  
Bernardo Galvão Castro ◽  
...  

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