scholarly journals Analysis of the cell fusion activities of chimeric simian immunodeficiency virus-murine leukemia virus envelope proteins: inhibitory effects of the R peptide.

1996 ◽  
Vol 70 (1) ◽  
pp. 248-254 ◽  
Author(s):  
C Yang ◽  
R W Compans
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Cell Fusion ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Envelope Proteins ◽  
Inhibitory Effects ◽  
Virus Envelope ◽  
Immunodeficiency Virus ◽  
Murine Leukemia

scholarly journals Suppression of Rat Bone Marrow Cells by Friend Murine Leukemia Virus Envelope Proteins

Virology ◽  
1998 ◽  
Vol 242 (2) ◽  
pp. 357-365 ◽  
Author(s):  
Stefan Mazgareanu ◽  
Justus G. Müller ◽  
Stefanie Czub ◽  
Simone Schimmer ◽  
Martin Bredt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Murine Leukemia Virus ◽  
Bone Marrow Cells ◽  
Leukemia Virus ◽  
Envelope Proteins ◽  
Virus Envelope ◽  
Murine Leukemia ◽  
Rat Bone ◽  
Marrow Cells

The nature of the association between the murine leukemia virus envelope proteins

Virology ◽  
1978 ◽  
Vol 91 (2) ◽  
pp. 345-351 ◽  
Author(s):  
Abraham Pinter ◽  
Judy Lieman-Hurwitz ◽  
Erwin Fleissner
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Envelope Proteins ◽  
Virus Envelope ◽  
Murine Leukemia

scholarly journals Functional Characterization of the N Termini of Murine Leukemia Virus Envelope Proteins

2001 ◽  
Vol 75 (9) ◽  
pp. 4357-4366 ◽  
Author(s):  
Chi-Wei Lu ◽  
Monica J. Roth
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Functional Characterization ◽  
Virus Titer ◽  
Envelope Proteins ◽  
Virus Envelope ◽  
C Terminus ◽  
N Terminus ◽  
Env Protein ◽  
Murine Leukemia

ABSTRACT The function of the N terminus of the murine leukemia virus (MuLV) surface (SU) protein was examined. A series of five chimeric envelope proteins (Env) were generated in which the N terminus of amphotropic 4070A was replaced by equivalent sequences from ecotropic Moloney MuLV (M-MuLV). Viral titers of these chimeras indicate that exchange with homologous sequences could be tolerated, up to V17eco/T15ampho (crossover III). Constructs encoding the first 28 amino acids (aa) of ecotropic M-MuLV resulted in Env expression and binding to the receptor; however, the virus titer was reduced 5- to 45-fold, indicating a postbinding block. Additional exchange beyond the first 28 aa of ecotropic MuLV Env resulted in defective protein expression. These N-terminal chimeras were also introduced into the AE4 chimeric Env backbone containing the amphotropic receptor binding domain joined at the hinge region to the ecotropic SU C terminus. In this backbone, introduction of the first 17 aa of the ecotropic Env protein significantly increased the titer compared to that of its parental chimera AE4, implying a functional coordination between the N terminus of SU and the C terminus of the SU and/or transmembrane proteins. These data functionally dissect the N-terminal sequence of the MuLV Env protein and identify differential effects on receptor-mediated entry.

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