In vitro study of the NS2-3 protease of hepatitis C virus.

1997 ◽  
Vol 71 (9) ◽  
pp. 6373-6380 ◽  
Author(s):  
L Pieroni ◽  
E Santolini ◽  
C Fipaldini ◽  
L Pacini ◽  
G Migliaccio ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn

Molecules ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 1367 ◽  
Author(s):  
Shao-Ru Chen ◽  
An-Qi Wang ◽  
Li-Gen Lin ◽  
Hong-Cong Qiu ◽  
Yi-Tao Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Vitro Study ◽  
Vitro Study ◽  
Virus Activity ◽  
Spatholobus Suberectus

Role of TGF-β1 and C-Kit Mutations in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients: in vitro Study

2019 ◽  
Vol 84 (8) ◽  
pp. 941-953 ◽  
Author(s):  
M. E. El-Houseini ◽  
A. Ismail ◽  
A. A. Abdelaal ◽  
A. H. El-Habashy ◽  
Z. F. Abdallah ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Vitro Study ◽  
Vitro Study ◽  
Tgf Β1

scholarly journals Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

2004 ◽  
Vol 48 (10) ◽  
pp. 4006-4008 ◽  
Author(s):  
Jim Zhen Wu ◽  
Gary Larson ◽  
Zhi Hong
Keyword(s):  
Hepatitis C ◽  
Viral Infection ◽  
Nucleoside Analogue ◽  
In Vitro Study ◽  
Vitro Study ◽  
Action Mechanism ◽  
Nucleoside Phosphorylase ◽  
Dual Action

ABSTRACT An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to ribavirin for the treatment of hepatitis C viral infection. We have reported that viramidine mainly functions as a prodrug of ribavirin that is enriched in the liver. This in vitro study further explores viramidine's activity against nucleoside phosphorylase, a host enzyme that is responsible for phosphorolysis of ribavirin in vivo. Our experiments show that viramidine inhibits ribavirin phosphorolysis with a Ki of 2.5 μM. This result suggests that viramidine may act through a dual-action mechanism by serving as a prodrug of ribavirin and concomitantly as an inhibitor for nucleoside phosphorylase catabolism of ribavirin.

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