scholarly journals In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn

Molecules ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 1367 ◽  
Author(s):  
Shao-Ru Chen ◽  
An-Qi Wang ◽  
Li-Gen Lin ◽  
Hong-Cong Qiu ◽  
Yi-Tao Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Vitro Study ◽  
Vitro Study ◽  
Virus Activity ◽  
Spatholobus Suberectus

In vitro study of the NS2-3 protease of hepatitis C virus.

1997 ◽  
Vol 71 (9) ◽  
pp. 6373-6380 ◽  
Author(s):  
L Pieroni ◽  
E Santolini ◽  
C Fipaldini ◽  
L Pacini ◽  
G Migliaccio ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Vitro Study ◽  
Vitro Study

Role of TGF-β1 and C-Kit Mutations in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients: in vitro Study

2019 ◽  
Vol 84 (8) ◽  
pp. 941-953 ◽  
Author(s):  
M. E. El-Houseini ◽  
A. Ismail ◽  
A. A. Abdelaal ◽  
A. H. El-Habashy ◽  
Z. F. Abdallah ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Vitro Study ◽  
Vitro Study ◽  
Tgf Β1

scholarly journals Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2′-C-Methylcytidine, the Active Component of Valopicitabine

2006 ◽  
Vol 50 (10) ◽  
pp. 3444-3446 ◽  
Author(s):  
Lotte Coelmont ◽  
Jan Paeshuyse ◽  
Marc P. Windisch ◽  
Erik De Clercq ◽  
Ralf Bartenschlager ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Protease Inhibitor ◽  
Nucleoside Analogue ◽  
Active Component ◽  
Pyrimidine Nucleoside ◽  
Virus Activity ◽  
Hcv Protease

ABSTRACT Ribavirin antagonizes the in vitro anti-hepatitis C virus (HCV) activity of the pyrimidine nucleoside analogue 2′-C-methylcytidine, the active component of the experimental anti-HCV drug valopicitabine. In contrast, the combination of ribavirin with either the purine nucleoside analogue 2′-C-methyladenosine or the HCV protease inhibitor VX-950 resulted in an additive antiviral activity. These findings may have implications when planning clinical studies with valopicitabine.

Synthesis and anti-hepatitis C virus activity of novel ethyl 1H-indole-3-carboxylates in vitro

2010 ◽  
Vol 18 (16) ◽  
pp. 6143-6148 ◽  
Author(s):  
Grazia Sellitto ◽  
Aurora Faruolo ◽  
Paolo de Caprariis ◽  
Sergio Altamura ◽  
Giacomo Paonessa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Activity

scholarly journals Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

2004 ◽  
Vol 48 (10) ◽  
pp. 4006-4008 ◽  
Author(s):  
Jim Zhen Wu ◽  
Gary Larson ◽  
Zhi Hong
Keyword(s):  
Hepatitis C ◽  
Viral Infection ◽  
Nucleoside Analogue ◽  
In Vitro Study ◽  
Vitro Study ◽  
Action Mechanism ◽  
Nucleoside Phosphorylase ◽  
Dual Action

ABSTRACT An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to ribavirin for the treatment of hepatitis C viral infection. We have reported that viramidine mainly functions as a prodrug of ribavirin that is enriched in the liver. This in vitro study further explores viramidine's activity against nucleoside phosphorylase, a host enzyme that is responsible for phosphorolysis of ribavirin in vivo. Our experiments show that viramidine inhibits ribavirin phosphorolysis with a Ki of 2.5 μM. This result suggests that viramidine may act through a dual-action mechanism by serving as a prodrug of ribavirin and concomitantly as an inhibitor for nucleoside phosphorylase catabolism of ribavirin.

1233 GS-6620: A LIVER TARGETED NUCLEOTIDE PRODRUG WITH POTENT PAN-GENOTYPE ANTI-HEPATITIS C VIRUS ACTIVITY IN VITRO

2011 ◽  
Vol 54 ◽  
pp. S487 ◽  
Author(s):  
A.S. Ray ◽  
J.Y. Feng ◽  
T. Wang ◽  
K. Wong ◽  
L. Zhang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Activity

scholarly journals The Antiviral Efficacy of <i>Withania somnifera</i> (Ashwagandha) against Hepatitis C Virus Activity: <i>In Vitro</i> and <i>in Silico</i> Study

2020 ◽  
Vol 10 (09) ◽  
pp. 463-477 ◽  
Author(s):  
Dina Mofed ◽  
Wafaa Ahmed ◽  
Abdel-Rahman Zekri ◽  
Ola Said ◽  
Mohamed Rahouma ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
In Silico ◽  
Withania Somnifera ◽  
Antiviral Efficacy ◽  
Virus Activity
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