Human Immunodeficiency Virus Type 1 (HIV-1) Non-B Subtypes Are Similar to HIV-1 Subtype B in that Coreceptor Specificity Is a Determinant of Cytopathicity in Human Lymphoid Tissue Infected Ex Vivo
2001 ◽
Vol 75
(21)
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pp. 10520-10522
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Keyword(s):
Ex Vivo
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ABSTRACT We sought to determine the relationship between virus-mediated CD4+ T-lymphocyte cytopathicity and viral coreceptor preference among various human immunodeficiency virus type 1 (HIV-1) subtypes in an ex vivo-infected human lymphoid tissue model. Our data show that all R5 HIV-1 infections resulted in mild depletion of CD4+ T lymphocytes, whereas all X4 HIV-1 infections caused severe depletion of CD4+ T lymphocytes regardless of their subtype origin. Thus, at least for the viruses within subtypes A, B, C, and E that were tested, coreceptor specificity is a critical factor that determines the ability of HIV-1 to deplete CD4+ T cells in human lymphoid tissue infected ex vivo.
2004 ◽
Vol 78
(22)
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pp. 12689-12693
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2001 ◽
Vol 75
(21)
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pp. 10113-10117
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2001 ◽
Vol 75
(18)
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pp. 8842-8847
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2001 ◽
Vol 75
(17)
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pp. 8195-8202
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1998 ◽
Vol 72
(11)
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pp. 9345-9347
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1990 ◽
Vol 172
(4)
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pp. 1151-1158
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2000 ◽
Vol 74
(11)
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pp. 5347-5351
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