Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart

1992 ◽  
Vol 12 (3) ◽  
pp. 1404
Author(s):  
N Bacher ◽  
Y Zisman ◽  
E Berent ◽  
E Livneh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Gene Family ◽  
Related Gene ◽  
Isolation And Characterization ◽  
Kinase C

Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart

1991 ◽  
Vol 11 (1) ◽  
pp. 126-133 ◽  
Author(s):  
N Bacher ◽  
Y Zisman ◽  
E Berent ◽  
E Livneh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Gene Family ◽  
Phorbol Esters ◽  
Structural Features ◽  
Cos Cells ◽  
Isolation And Characterization ◽  
Kinase C ◽  
Human Epidermoid Carcinoma

We have isolated and characterized a new human cDNA, coding for a protein kinase, related to the protein kinase C (PKC) gene family. Although this protein kinase shares some homologous sequences and structural features with the four members of the PKC family initially isolated (alpha, beta I, beta II, and gamma), it shows more homology with the recently described PKC-related subfamily, encoded by the cDNAs delta, epsilon, and zeta. The transcript for this gene product, termed PKC-L, is most abundant in lung tissue, less expressed in heart and skin tissue, and exhibited very low expression in brain tissue. Thus, its tissue distribution is different from that described for other mammalian members of the PKC gene family, their expression being enriched in brain tissues. PKC-L is also expressed in several human cell lines, including the human epidermoid carcinoma line A431. The ability of phorbol esters to bind to and stimulate the kinase activity of PKC-L was revealed by introducing the cDNA into COS cells.

scholarly journals Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.

1991 ◽  
Vol 11 (1) ◽  
pp. 126-133 ◽  
Author(s):  
N Bacher ◽  
Y Zisman ◽  
E Berent ◽  
E Livneh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Gene Family ◽  
Phorbol Esters ◽  
Structural Features ◽  
Cos Cells ◽  
Isolation And Characterization ◽  
Kinase C ◽  
Human Epidermoid Carcinoma

We have isolated and characterized a new human cDNA, coding for a protein kinase, related to the protein kinase C (PKC) gene family. Although this protein kinase shares some homologous sequences and structural features with the four members of the PKC family initially isolated (alpha, beta I, beta II, and gamma), it shows more homology with the recently described PKC-related subfamily, encoded by the cDNAs delta, epsilon, and zeta. The transcript for this gene product, termed PKC-L, is most abundant in lung tissue, less expressed in heart and skin tissue, and exhibited very low expression in brain tissue. Thus, its tissue distribution is different from that described for other mammalian members of the PKC gene family, their expression being enriched in brain tissues. PKC-L is also expressed in several human cell lines, including the human epidermoid carcinoma line A431. The ability of phorbol esters to bind to and stimulate the kinase activity of PKC-L was revealed by introducing the cDNA into COS cells.

Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells

Cell ◽  
1989 ◽  
Vol 57 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Eric Schaeffer ◽  
Dean Smith ◽  
Graeme Mardon ◽  
William Quinn ◽  
Charles Zuker
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Photoreceptor Cells ◽  
Isolation And Characterization ◽  
Kinase C ◽  
Drosophila Protein

Isolation and characterization of protein kinase C from human placenta

Placenta ◽  
1990 ◽  
Vol 11 (1) ◽  
pp. 27-33 ◽  
Author(s):  
C. Tertrin-Clary ◽  
M.C. Chenut ◽  
P. De la Llosa
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Human Placenta ◽  
Isolation And Characterization ◽  
Kinase C

scholarly journals Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.

1987 ◽  
Vol 84 (4) ◽  
pp. 1065-1069 ◽  
Author(s):  
G. M. Housey ◽  
C. A. O'Brian ◽  
M. D. Johnson ◽  
P. Kirschmeier ◽  
I. B. Weinstein
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Gene Family ◽  
Cdna Clones ◽  
Related Gene ◽  
Kinase C ◽  
Encoding Protein

scholarly journals Isolation and characterization of frog retina protein kinase C

1990 ◽  
Vol 52 ◽  
pp. 364
Author(s):  
Motomu Terasawa ◽  
Masatoshi Hagiwara ◽  
Takahisa Hachiya ◽  
Ryoji Kobayashi ◽  
Hiroyoshi Hidaka
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Isolation And Characterization ◽  
Kinase C ◽  
Frog Retina

scholarly journals Isolation and characterization of delta-subspecies of protein kinase C from rat brain.

1992 ◽  
Vol 89 (5) ◽  
pp. 1592-1596 ◽  
Author(s):  
K. Ogita ◽  
S. Miyamoto ◽  
K. Yamaguchi ◽  
H. Koide ◽  
N. Fujisawa ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Brain ◽  
Isolation And Characterization ◽  
Kinase C
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