Plasmid Replication Control by Antisense RNAs

2014 ◽  
Vol 2 (4) ◽  
Author(s):  
Sabine Brantl
Keyword(s):  
Plasmid Replication ◽  
Antisense Rnas ◽  
Replication Control

Four-way Junctions in Antisense RNA-mRNA Complexes Involved in Plasmid Replication Control: A Common Theme?

2001 ◽  
Vol 309 (3) ◽  
pp. 605-614 ◽  
Author(s):  
Fabrice A. Kolb ◽  
Eric Westhof ◽  
Bernard Ehresmann ◽  
Chantal Ehresmann ◽  
E.Gerhart H. Wagner ◽  
...  
Keyword(s):  
Antisense Rna ◽  
Plasmid Replication ◽  
Common Theme ◽  
Replication Control

scholarly journals Crosstalk between vertical and horizontal gene transfer: plasmid replication control by a conjugative relaxase

2017 ◽  
Vol 45 (13) ◽  
pp. 7774-7785 ◽  
Author(s):  
Fabián Lorenzo-Díaz ◽  
Cris Fernández-López ◽  
Rudi Lurz ◽  
Alicia Bravo ◽  
Manuel Espinosa
Keyword(s):  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Plasmid Replication ◽  
Replication Control ◽  
Transfer Plasmid

ColEl PLASMID REPLICATION CONTROL

1980 ◽  
pp. 313-323
Author(s):  
Barry Polisky ◽  
David Gelfand ◽  
H. Michael Shepard
Keyword(s):  
Plasmid Replication ◽  
Replication Control

scholarly journals Analysis of the individual regulatory components of the IncFII plasmid replication control system.

1985 ◽  
Vol 161 (2) ◽  
pp. 534-543 ◽  
Author(s):  
D D Womble ◽  
X Dong ◽  
V A Luckow ◽  
R P Wu ◽  
R H Rownd
Keyword(s):  
Control System ◽  
Plasmid Replication ◽  
Replication Control ◽  
The Individual

scholarly journals Using the Price equation to analyze multi-level selection on the reproductive policing mechanism of bacterial plasmids

2016 ◽  
Author(s):  
Kyriakos Kentzoglanakis ◽  
Sam P. Brown ◽  
Richard A. Goldstein
Keyword(s):  
Control System ◽  
Growth Rates ◽  
Price Equation ◽  
Plasmid Replication ◽  
Special Role ◽  
Selective Pressures ◽  
Bacterial Plasmids ◽  
Replication Control ◽  
Multi Level ◽  
Cellular Replication

AbstractThe replication control system of non-conjugative bacterial plasmids constitutes a simple and elegant example of a reproductive policing mechanism that moderates competition in the intra-cellular replication pool and establishes a mutually beneficial partnership among plasmids within a bacterial host and between plasmids and their hosts. The emergence of these partnerships is a product of the conflict between the evolutionary interests of hosts, who seek to maximize their growth rates within the population, and plasmids, who seek to maximize their growth rates within hosts. We employ a multi-scale computational model describing the growth, division and death of hosts, as well as the independent replication of plasmids within hosts, in order to investigate the implications of this conflict for the evolution of the plasmid replication parameters. We apply the multi-level form of the Price equation in order to quantify and elucidate the various selective pressures that drive the evolution of plasmid replication control. Our analysis shows how the evolution of the constituent components of the plasmid replication control system are shaped by selection acting at the level of hosts and the level of plasmids. In addition, we calculate finer-grained selective pressures that are attributed to atomic plasmid-related events (such as intra-cellular replication and plasmid loss due to host death) and demonstrate their special role at the early stages of the evolution of policing. Our approach constitutes a novel application of the Price equation for discerning and discussing the synergies between the levels of selection given the availability of a mechanistic model for the generation of the system’s dynamics. We show how the Price equation, particularly in its multi-level form, can provide significant insight by quantifying the relative importance of the various selective forces that shape the evolution of policing in bacterial plasmids.

Incompatibility and INCFII Plasmid Replication Control

1985 ◽  
pp. 335-354 ◽  
Author(s):  
Robert H. Rownd ◽  
David D. Womble ◽  
Xin-nian Dong ◽  
Verne A. Luckow ◽  
Ru Ping Wu
Keyword(s):  
Plasmid Replication ◽  
Replication Control

scholarly journals Multileveled Selection on Plasmid Replication

Genetics ◽  
2002 ◽  
Vol 161 (4) ◽  
pp. 1373-1384 ◽  
Author(s):  
Johan Paulsson
Keyword(s):  
Arms Race ◽  
Plasmid Replication ◽  
Site Specific ◽  
Site Specific Recombination ◽  
Cis Acting ◽  
Replication Control ◽  
Kinetic Mechanisms ◽  
Selection For ◽  
Level Of Selection ◽  
Lower Loss

Abstract The replication control genes of bacterial plasmids face selection at two conflicting levels. Plasmid copies that systematically overreplicate relative to their cell mates have a higher chance of fixing in descendant cells, but these cells typically have a lower chance of fixing in the population. Apart from identifying the conflict, this mathematical discussion characterizes the efficiency of the selection levels and suggests how they drive the evolution of kinetic mechanisms. In particular it is hypothesized that: (1) tighter replication control is more vulnerable to selfishness; (2) cis-acting replication activators are relics of a conflict where a plasmid outreplicated its intracellular competitors by monopolizing activators; (3) high-copy plasmids with sloppy replication control arise because intracellular selection favors overreplication, thereby relieving intercellular selection for lower loss rates; (4) the excessive synthesis of cis-acting replication activators and trans-acting inhibitors is the result of an arms race between cis selfishness and trans retaliations; (5) site-specific recombination of plasmid dimers is equivalent to self-policing; and (6) plasmids modify their horizontal transfer to spread without promoting selfishness. It is also discussed how replication control may be subject to a third level of selection acting on the entire population of plasmid-containing cells.

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