scholarly journals Population Pharmacokinetics and Dosing Optimization of Piperacillin-Tazobactam in Critically Ill Patients on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Jongsung Hahn ◽  
Kyoung Lok Min ◽  
Soyoung Kang ◽  
Seungwon Yang ◽  
Min Soo Park ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Renal Replacement Therapy ◽  
Critical Illness ◽  
Extracorporeal Membrane Oxygenation ◽  
Replacement Therapy ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Concentration Data ◽  
Dosing Optimization

To the best of our knowledge, this is the first large prospective pharmacokinetic/pharmacodynamic (PK/PD) study of piperacillin-tazobactam in ECMO patients. We used piperacillin-tazobactam plasma concentration data from four different cases (concomitant use of ECMO and CVVHDF, receiving ECMO only, weaned from ECMO and receiving CVVHDF, and weaned from ECMO and not receiving CVVHDF) to provide preliminary insights into the incremental effects of critical illness, ECMO, and CVVHDF on PK.

scholarly journals Renal Replacement Therapy in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation

2012 ◽  
Vol 7 (8) ◽  
pp. 1328-1336 ◽  
Author(s):  
David J. Askenazi ◽  
David T. Selewski ◽  
Matthew L. Paden ◽  
David S. Cooper ◽  
Brian C. Bridges ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Extracorporeal Membrane Oxygenation ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Membrane Oxygenation

scholarly journals Population Pharmacokinetics of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy

2008 ◽  
Vol 47 (3) ◽  
pp. 173-180 ◽  
Author(s):  
Arantxazu Isla ◽  
Alicia Rodríguez-Gascón ◽  
Iñaki F Trocóniz ◽  
Lorea Bueno ◽  
María Ángeles Solinís ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients

Population pharmacokinetics and dosing considerations of daptomycin in critically ill patients undergoing continuous renal replacement therapy

2020 ◽  
Vol 75 (6) ◽  
pp. 1559-1566
Author(s):  
Feifan Xie ◽  
Sanwang Li ◽  
Zeneng Cheng
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
High Probability ◽  
Population Pharmacokinetic ◽  
Target Attainment ◽  
Concentration Data ◽  
Concentration Threshold

Abstract Objectives The dosing regimen of daptomycin for critically ill patients undergoing continuous renal replacement therapy (CRRT) remains controversial. The goal of this study was to provide guidance for optimal daptomycin therapy in CRRT patients with Staphylococcus aureus infections. Methods Individual concentration data of 32 CRRT subjects pooled from previously published studies were used to construct the population pharmacokinetic model for daptomycin. Model-based simulations were performed to evaluate the efficacy and risk of toxicity for daptomycin doses of 4, 6 and 8 mg/kg, q24h or q48h, under CRRT doses of 25, 30 and 35 mL/h/kg. Efficacy was assessed by the bacteriostatic and bactericidal AUC/MIC targets and drug exposure-based efficacy references. Toxicity was estimated by safety exposure references and the trough concentration threshold. Results A two-compartment model adequately described the pharmacokinetics of daptomycin. Efficacy analysis demonstrated that q48h dosing is associated with an extremely low probability of bactericidal target attainment on every second day after dosing and q24h dosing is preferred for a high probability of bactericidal target attainment. Toxicity evaluation showed that 8 mg/kg q24h has a high probability for reaching the toxicity-related concentration threshold, while 6 mg/kg q24h gives a satisfactory risk–benefit balance. The studied CRRT doses had a limited impact on efficacy and a CRRT dose of 30–35 mL/h/kg may lower the risk of toxicity. Conclusions The model predicted that the combination of 6 mg/kg q24h daptomycin dose and CRRT dose of 30–35 mL/h/kg would achieve the best balance of efficacy and safety.

Sign in / Sign up

Export Citation Format

Share Document