Influence of ATP-dependent K+-channel opener on K+-cycle and oxygen consumption in rat liver mitochondria

2010 ◽  
Vol 75 (9) ◽  
pp. 1139-1147 ◽  
Author(s):  
O. V. Akopova ◽  
V. I. Nosar ◽  
V. A. Bouryi ◽  
I. N. Mankovskaya ◽  
V. F. Sagach
Keyword(s):  
Oxygen Consumption ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
K Channel ◽  
Rat Liver Mitochondria ◽  
Channel Opener ◽  
K Channel Opener

Effect of melatonin treatment on oxygen consumption by rat liver mitochondria

Amino Acids ◽  
2006 ◽  
Vol 31 (3) ◽  
pp. 299-302 ◽  
Author(s):  
C. F. Reyes-Toso ◽  
I. R. Rebagliati ◽  
C. R. Ricci ◽  
L. M. Linares ◽  
L. E. Albornoz ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Melatonin Treatment

scholarly journals The monophenolic metabolites of the herbicide 2,6-dichlorobenzonitrile in animals as uncouplers of oxidative phosphorylation

1966 ◽  
Vol 101 (3) ◽  
pp. 707-710 ◽  
Author(s):  
JG Wit ◽  
H Van Genderen
Keyword(s):  
Oxygen Consumption ◽  
Oxidative Phosphorylation ◽  
Rat Liver ◽  
Adenosine Triphosphatase ◽  
Hepatic Injury ◽  
Liver Mitochondria ◽  
Significant Rise ◽  
Yeast Cells ◽  
Rat Liver Mitochondria

1. Both monophenolic metabolites of 2,6-dichlorobenzonitrile (2,6-dichloro-3-hydroxybenzonitrile and its 4-hydroxy analogue) added to starved yeast cells incubated with a limited quantity of glucose cause a significant rise in oxygen consumption of the cells. 2. The same compounds induce adenosine-triphosphatase activity in isolated intact rat-liver mitochondria. 3. The possible role of the hydroxylation of 2,6-dichlorobenzonitrile in mammals in relation to hepatic injury is discussed.

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

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