In many industries, such as mechanical engineering and aerospace, traditional alloys are being replaced by metal matrix composites (MCM). Compared to unreinforced alloys, MCM is characterized by increased strength and rigidity combined with low density. To calculate the resource of nodes for the safe and reliable operation of new equipment, it is necessary to have a set of calculated values of the MCM strength characteristics, including the characteristics of short-term and long-term strength, low-cycle (LCF) and high-cycle (HCF) fatigue. The work is devoted to the study of the characteristics of short-term and long-term strength, LCF and MCF fatigue of dispersion-strengthened MKM grade VKM22.