Semisynthesis of peptides - New strategy for specific protection and deprotection of the α-amino group of recombinantly-produced peptide fragments

1999 ◽  
Author(s):  
Johann M. Brass ◽  
Julie Frank ◽  
Fred W. Wagner ◽  
Hans Stocker ◽  
Erich Wünsch
Keyword(s):  
Amino Group ◽  
Peptide Fragments ◽  
New Strategy

scholarly journals Covalent Linkage of Polyamines to Peptidoglycan inAnaerovibrio lipolytica

2000 ◽  
Vol 182 (4) ◽  
pp. 1154-1157 ◽  
Author(s):  
Takashi Hirao ◽  
Masahide Sato ◽  
Akira Shirahata ◽  
Yoshiyuki Kamio
Keyword(s):  
Glutamic Acid ◽  
Anaerobic Bacterium ◽  
Diaminopimelic Acid ◽  
Molar Ratio ◽  
Carboxyl Group ◽  
Strictly Anaerobic ◽  
Amino Group ◽  
Peptide Fragments ◽  
Covalent Linkage ◽  
Glutamic Acid Residue

ABSTRACT Spermidine and cadaverine were found to be constituents of the cell wall peptidoglycan of Anaerovibrio lipolytica, a strictly anaerobic bacterium. The peptidoglycan was degraded with theN-acetylmuramyl-l-alanine amidase and endopeptidase into two peptide fragments, peptide I and peptide II, at a molar ratio of 4:1. Peptides I and II were identified asl-alanine–d-glutamic acid(αcadaverine)γ meso-diaminopimelic acid (DAP)–d-alanine andl-alanine–d-glutamic acid(αspermidine)γ meso-DAP–d-alanine, respectively. The N1-amino group of spermidine was linked to the α-carboxyl group of the d-glutamic acid residue of peptide II.

Tricyclic “oxadiazaphosphorine oxide” guanosines A new strategy to functionalize guanosine at the exocyclic amino group

1995 ◽  
Vol 36 (37) ◽  
pp. 6651-6654 ◽  
Author(s):  
Sébastien Robidoux ◽  
Yunkui Guo ◽  
Masad J. Damha
Keyword(s):  
Amino Group ◽  
New Strategy

K2S2O8-Activated Friedel–Crafts Type Alkylation of Indoles with α-Amido Sulfones

Synthesis ◽  
2017 ◽  
Vol 49 (22) ◽  
pp. 5017-5024 ◽  
Author(s):  
Wenling Qin ◽  
Xiaoyan Wu ◽  
Lu Xue ◽  
Shilong Luo ◽  
Shiqi Jia ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Lewis Acid ◽  
Amino Group ◽  
Mechanism Study ◽  
Previous Approach ◽  
Regioselective Alkylation ◽  
Wide Range ◽  
New Strategy ◽  
Formed Product ◽  
Electron Donating Groups

A K2S2O8-activated regioselective alkylation of α-amido sulfones at the C-3 position of indoles is reported. The protocol developed herein provides an alternative new strategy to the previous approach by using Lewis acid, clay, and resin as catalyst for this Friedel–Crafts type alkylation of indoles with α-amido sulfones. The formed product bears a versatile transformable sulfone group and an amino group. The reaction condition is tolerant to a wide range of substrates, including a series of indoles with electron-withdrawing and electron-donating groups at different positions. Moreover, a variety of α-substituted phenylamido sulfones and some α-aliphatic amido sulfones also give the desired products in modest yield. Furthermore, a preliminary mechanism study was performed and the plausible reaction mechanism is discussed.

A new strategy for prenatal diagnosis in a sporadic haemophilia B family

Haemophilia ◽  
2001 ◽  
Vol 7 (4) ◽  
pp. 416-418 ◽  
Author(s):  
M. Acquila ◽  
F. Bottini ◽  
A. Valetto ◽  
D. Caprino ◽  
P. G. Mori ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Haemophilia B ◽  
New Strategy

Guidelines Bring New Strategy in Low-Risk AF

2012 ◽  
Vol 45 (15) ◽  
pp. 12-13
Author(s):  
BRUCE JANCIN
Keyword(s):  
Low Risk ◽  
New Strategy

New Strategy for the Synthesis of 2-Deoxy-C-aryl-nucleoside Frameworks

2006 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
S.M. Mahalingam ◽  
S. Vijayasaradhi ◽  
I.S. Aidhen
Keyword(s):  
New Strategy

Practice Directorate: Practice Directorate pursues new strategy

1995 ◽  
Author(s):  
Scott Sleek ◽  
Keyword(s):  
New Strategy

NMR studies of the R2 repeat and related peptide fragments of the DNA binding domain of c-Myb. New light on the structure and folding of R2.

1999 ◽  
Vol 96 (9/10) ◽  
pp. 1580-1584 ◽  
Author(s):  
I. Ségalas ◽  
S. Desjardins ◽  
H. Oulyadi ◽  
Y. Prigent ◽  
S. Tribouillard ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Peptide Fragments ◽  
Nmr Studies ◽  
Related Peptide

New strategy to search lead compounds with unique structures from plants

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Villani ◽  
K Gustafson ◽  
J Zhen ◽  
JE Simon ◽  
Q Wu
Keyword(s):  
Lead Compounds ◽  
New Strategy
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