Thymidine (monophosphate) analogues as Mycobacterium tuberculosis thymidylate kinase inhibitors

2002 ◽  
Author(s):  
Philippe Van Rompaey ◽  
Vanheusden Veerle ◽  
Sylvie Pochet ◽  
Hélene Munier-Lehmann ◽  
Matheus Froeyen ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Kinase Inhibitors ◽  
Thymidylate Kinase ◽  
Thymidine Monophosphate

scholarly journals Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

2013 ◽  
Vol 21 (1) ◽  
pp. 257-268 ◽  
Author(s):  
Kiran S. Toti ◽  
Frederick Verbeke ◽  
Martijn D.P. Risseeuw ◽  
Vladimir Frecer ◽  
Hélène Munier-Lehmann ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Kinase Inhibitors ◽  
Thymidylate Kinase

Design of Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors

ChemInform ◽  
2004 ◽  
Vol 35 (4) ◽  
Author(s):  
H. Munier-Lehmann ◽  
S. Pochet ◽  
L. Dugue ◽  
O. Dutruel ◽  
G. Labesse ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Kinase Inhibitors ◽  
Thymidine Monophosphate

scholarly journals Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2′- and 3′-Modified Thymidine Analogues

2003 ◽  
Vol 2003 (15) ◽  
pp. 2911-2918 ◽  
Author(s):  
Philippe Van Rompaey ◽  
Koen Nauwelaerts ◽  
Veerle Vanheusden ◽  
Jef Rozenski ◽  
Hélène Munier-Lehmann ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Conformational Analysis ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Thymidine Monophosphate

scholarly journals In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

2020 ◽  
Vol Volume 14 ◽  
pp. 1027-1039 ◽  
Author(s):  
Katharigatta N Venugopala ◽  
Christophe Tratrat ◽  
Melendhran Pillay ◽  
Sandeep Chandrashekharappa ◽  
Omar Husham Ahmed Al-Attraqchi ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
In Silico ◽  
Kinase Inhibitors ◽  
Thymidylate Kinase ◽  
In Silico Design ◽  
Design And Synthesis

Exploring Pyrimidine Pharmacophore as Thymidine Monophosphate Kinase Inhibitors for Antitubercular Activity: A Review

2016 ◽  
Vol 16 (28) ◽  
pp. 3211-3223 ◽  
Author(s):  
Trupti Sameer Chitre ◽  
Kalyani Dhirendra Asgaonkar ◽  
Shital Manoj Patil ◽  
Muthu Kumaradoss Kathiravan ◽  
Subhash Balkrishna Padhye
Keyword(s):  
Kinase Inhibitors ◽  
Antitubercular Activity ◽  
Thymidine Monophosphate

Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM/MM docking studies

2012 ◽  
Vol 19 (1) ◽  
pp. 179-192 ◽  
Author(s):  
Renata V. Bueno ◽  
Ney R. Toledo ◽  
Bruno J. Neves ◽  
Rodolpho C. Braga ◽  
Carolina H. Andrade
Keyword(s):  
Kinase Inhibitors ◽  
Docking Studies ◽  
Chemical Basis ◽  
Thymidine Monophosphate

Synthesis and Evaluation of Thymidine-5′-O-monophosphate Analogues as Inhibitors of Mycobacterium tuberculosis Thymidylate Kinase.

ChemInform ◽  
2003 ◽  
Vol 34 (2) ◽  
Author(s):  
Veerle Vanheusden ◽  
Helene Munier-Lehmann ◽  
Sylvie Pochet ◽  
Piet Herdewijn ◽  
Serge Van Calenbergh
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Thymidylate Kinase

3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods

2006 ◽  
Vol 16 (4) ◽  
pp. 1014-1020 ◽  
Author(s):  
V. Aparna ◽  
J. Jeevan ◽  
M. Ravi ◽  
G.R. Desiraju ◽  
B. Gopalakrishnan
Keyword(s):  
Kinase Inhibitors ◽  
3D Qsar ◽  
Qsar Studies ◽  
Thymidine Monophosphate

scholarly journals Thymidylate kinase of Mycobacterium tuberculosis: A chimera sharing properties common to eukaryotic and bacterial enzymes

2001 ◽  
Vol 10 (6) ◽  
pp. 1195-1205 ◽  
Author(s):  
HÉLÈNE Munier-Lehmann ◽  
Alain Chaffotte ◽  
Sylvie Pochet ◽  
Gilles Labesse
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Bacterial Enzymes ◽  
Thymidylate Kinase

scholarly journals Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

2011 ◽  
Vol 19 (24) ◽  
pp. 7603-7611 ◽  
Author(s):  
Sara Van Poecke ◽  
Hélène Munier-Lehmann ◽  
Olivier Helynck ◽  
Matheus Froeyen ◽  
Serge Van Calenbergh
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Inhibitory Activity ◽  
Thymidine Monophosphate
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