FRI0391 Evaluation of peripheral blood perfusion by laser speckle contrast analysis in systemic sclerosis patients: comparison with laser doppler flowmetry.

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A505.2-A505
Author(s):  
B. Ruaro ◽  
A. Sulli ◽  
C. Pizzorni ◽  
G. Ferrari ◽  
F. Ravera ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Laser Doppler Flowmetry ◽  
Peripheral Blood ◽  
Blood Perfusion ◽  
Laser Speckle ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Speckle Contrast ◽  
Contrast Analysis ◽  
Laser Speckle Contrast Analysis

Laser speckle contrast analysis: a new method to evaluate peripheral blood perfusion in systemic sclerosis patients

2013 ◽  
Vol 73 (6) ◽  
pp. 1181-1185 ◽  
Author(s):  
Barbara Ruaro ◽  
Alberto Sulli ◽  
Elisa Alessandri ◽  
Carmen Pizzorni ◽  
Giorgia Ferrari ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Peripheral Blood ◽  
Blood Perfusion ◽  
Laser Speckle ◽  
New Method ◽  
Speckle Contrast ◽  
Contrast Analysis ◽  
Laser Speckle Contrast Analysis

OP0128 Evaluation of Peripheral Blood Perfusion by Laser Speckle Contrast Analysis in Systemic Sclerosis Patients Treated with Aminaphtone

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 104.2-104
Author(s):  
B. Ruaro ◽  
C. Pizzorni ◽  
A.C. Trombetta ◽  
S. Paolino ◽  
E. Bernero ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Peripheral Blood ◽  
Blood Perfusion ◽  
Laser Speckle ◽  
Speckle Contrast ◽  
Contrast Analysis ◽  
Laser Speckle Contrast Analysis

scholarly journals THU0334 LASER SPECKLE CONTRAST ANALYSIS FOR MEASUREMENT OF PERIPHERAL BLOOD PERFUSION IN SYSTEMIC SCLEROSIS PATIENTS: CAN IT PREDICT FUTURE ISCHEMIC DIGITAL TROPHIC LESIONS?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 398.1-398
Author(s):  
C. Debusschere ◽  
A. Vanhaecke ◽  
M. Cutolo ◽  
E. Deschepper ◽  
V. Smith
Keyword(s):  
Logistic Regression ◽  
Systemic Sclerosis ◽  
Peripheral Blood ◽  
Blood Perfusion ◽  
Laser Speckle ◽  
Research Support ◽  
Speckle Contrast ◽  
Contrast Analysis ◽  
Laser Speckle Contrast Analysis

Background:Vasculopathy is a hallmark of systemic sclerosis (SSc). Laser speckle contrast analysis (LASCA) is a research tool to assess peripheral blood perfusion (PBP) (1). At this moment, its reliability has been attested in SSc patients, but its predictive value for future ischemic digital trophic lesions (DTL) is unknown (1).Objectives:To investigate in an unselected, prospective SSc cohort if baseline LASCA PBP measurements can discriminate between patients who will develop ischemic DTL (iDTL) and those who will not.Methods:Patients (fulfilling 2013 ACR/EULAR criteria and/or 2001 LeRoy and Medsger criteria) were recruited during the period of December 2017 to September 2018. LASCA was performed at baseline, in standardized conditions (1). Regions of interest (ROIs) (diameter 1 cm) were outlined at the 2nd-5thfingertip both volar and dorsal. The ‘average PBP’ of these ROIs was calculated (expressed in arbitrary perfusion units [PU]). A monthly telephone survey was conducted for 1 year to investigate DTL occurrence. DTL were considered ‘ischemic’ if not related to calcinosis. Logistic regression and ROC analysis were used to assess if average PBP is predictive of future iDTL.Results:Of the 106 patients with complete follow-up (92 women [86,8%]; 18 limited SSc [17,0%], 82 limited cutaneous SSc [77,4%], 6 diffuse cutaneous SSc [5,7%]), 29 patients (27,4%) had a DTL history. Forty-nine patients (46,2%) were on vasodilator therapy. Only 7 patients developed at least 1 iDTL during follow-up (6,6%) (Figure 1a). Performing univariate logistic regression (ULR), average PBP was not predictive for future iDTL (Table 1). Of note, analyzing only the patients not taking vasodilators, average PBP in the ‘iDTL group’ (n = 3) was median 46,8 PU (min. 45,6 - max. 68,8) vs. median 141,4 PU (min. 24,4 - max. 269,5) in the ‘no iDTL group’ (n = 54) (Figure 1b). In this subgroup, all 3 patients who developed iDTL (100%) had an average PBP ≤ 70 PU whereas only 9 of the 54 patients without iDTL development (16,7%) had such PBP values.Table 1.Results of ULRSummary statisticsULRVariableiDTL cases(n = 7)Non-iDTL cases(n = 99)ParameterOR(95% CI)pROC AUC(95% CI)Average PBP (PU) mean (+/- SD)123,0 (74,6)142,9 (61,9)Average PBP (linear)0,995(0,982-1,007)0,4180,597(0,352-0,843)Conclusion:In this pilot study with an unselected day-to-day SSc population, where patients were allowed to continue vasodilators, there was an unexpected low iDTL incidence, undermining the power of our study. Even though, the observations in the subgroup of patients not taking vasodilators deserve future investigation to assess whether low PBP values, as measured by LASCA, are associated with a higher iDTL incidence.References:[1]Cutolo M, Vanhaecke A, et al. Autoimmun Rev. 2018;17(8):775-80.Figure 1.Distribution of ‘average PBP’ as measured by LASCA for ‘no iDTL group’ and ‘iDTL group’Disclosure of Interests:Claire Debusschere: None declared, Amber Vanhaecke: None declared, Maurizio Cutolo Grant/research support from: Bristol-Myers Squibb, Actelion, Celgene, Consultant of: Bristol-Myers Squibb, Speakers bureau: Sigma-Alpha, Ellen Deschepper: None declared, Vanessa Smith Grant/research support from: The affiliated company received grants from Research Foundation - Flanders (FWO), Belgian Fund for Scientific Research in Rheumatic diseases (FWRO), Boehringer Ingelheim Pharma GmbH & Co and Janssen-Cilag NV, Consultant of: Boehringer-Ingelheim Pharma GmbH & Co, Speakers bureau: Actelion Pharmaceuticals Ltd, Boehringer-Ingelheim Pharma GmbH & Co and UCB Biopharma Sprl

Reliability of the quantitative assessment of peripheral blood perfusion by laser speckle contrast analysis in a systemic sclerosis cohort

2016 ◽  
Vol 75 (6) ◽  
pp. 1263-1264 ◽  
Author(s):  
Valérie Lambrecht ◽  
Maurizio Cutolo ◽  
Filip De Keyser ◽  
Saskia Decuman ◽  
Barbara Ruaro ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Peripheral Blood ◽  
Quantitative Assessment ◽  
Blood Perfusion ◽  
Laser Speckle ◽  
Speckle Contrast ◽  
Contrast Analysis ◽  
Laser Speckle Contrast Analysis

FRI0382 Laser speckle contrast analysis (LASCA) a new method to evaluate blood perfusion in different skin areas of systemic sclerosis patients

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A502.3-A502
Author(s):  
A. Sulli ◽  
B. Ruaro ◽  
F. Ravera ◽  
E. Alessandri ◽  
E. Bernero ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Blood Perfusion ◽  
Laser Speckle ◽  
New Method ◽  
Speckle Contrast ◽  
Contrast Analysis ◽  
Laser Speckle Contrast Analysis
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