scholarly journals Head and neck cutaneous metastasis of testicular choriocarcinoma

2020 ◽  
Vol 13 (2) ◽  
pp. e233337
Author(s):  
Sepehr Shabani ◽  
Nicholas Pritchard ◽  
Tapan A Padhya ◽  
Matthew Mifsud
Keyword(s):  
Germ Cell ◽  
Surgical Intervention ◽  
Germ Cell Tumour ◽  
Cutaneous Metastasis ◽  
Palliative Surgery ◽  
Potential Utility ◽  
Unique Case ◽  
Metastatic Focus ◽  
Lower Lip ◽  
Life Threatening

Testicular choriocarcinoma (CC) is a malignant germ cell tumour which most frequently presents with disseminated metastasis, often involving the lungs, brain and liver. Metastatic are characterised by extensive vascularity, often causing patients to present emergently with potentially life-threatening haemorrhagic complications. We report a patient with disseminated testicular CC, presenting with haemorrhage from a dermal metastatic focus involving the lower lip and mentum, requiring surgical intervention. This unique case illustrates the potential utility of palliative surgery, for the management of symptomatic metastatic disease, such as those caused by testicular CC.

scholarly journals Cutaneous metastasis from testicular germ cell tumour

2014 ◽  
Vol 30 (1) ◽  
pp. 99 ◽  
Author(s):  
Anjana Joel ◽  
AmitDilip Bhatt ◽  
Abraham Samuel ◽  
RajuTitus Chacko
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cutaneous Metastasis ◽  
Cell Tumour ◽  
Testicular Germ Cell Tumour ◽  
Testicular Germ Cell

scholarly journals A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component

2011 ◽  
Vol 5 (5) ◽  
pp. E81-E83
Author(s):  
Luke T. Lavallée ◽  
Nicolas LD Roustan Delatour ◽  
Ilias Cagiannos ◽  
Eric C Bélanger ◽  
Kien T. Mai
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Yolk Sac ◽  
Cell Tumour ◽  
Unique Case

scholarly journals A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component

2013 ◽  
Vol 5 (5) ◽  
pp. 81
Author(s):  
Luke T. Lavallée ◽  
Nicolas LD Roustan Delatour ◽  
Ilias Cagiannos ◽  
Eric C. Bélanger ◽  
Kien T. Mai
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Treatment Strategies ◽  
Yolk Sac ◽  
Cell Tumour ◽  
Unique Case ◽  
Prior Chemotherapy ◽  
First Case

We present a unique case of a sarcoma arising in a testicularnon-seminomatous mixed germ cell tumour with a predominantyolk sac tumour (YST) component. This is the first case reported inwhich a sarcoma is linked to YST of the testis in a patient not havingundergone prior chemotherapy. This finding confirms the ability ofYST to contain sarcoma; it underlies its importance for urologists,oncologists and pathologists to be aware of this phenomenon andto modify treatment strategies appropriately.

ANKYLOBLEPHARON FILIFORM ADNATUM AND ITS RARE ASSOCIATED SYNDROMES-A UNIQUE CASE SERIES

2021 ◽  
pp. 5-6
Author(s):  
S. Anandhalakshmi ◽  
Suhas Prabhakar ◽  
M. Radhakrishnan ◽  
V. Aisvarya ◽  
Anniksha.M. N
Keyword(s):  
Cleft Palate ◽  
Local Anesthesia ◽  
Multidisciplinary Approach ◽  
Surgical Intervention ◽  
Ectodermal Dysplasia ◽  
Case Series ◽  
Unique Case ◽  
Life Threatening ◽  
Ophthalmologic Examination ◽  
Early Surgical Intervention

This paper presents a case series of two neonates reporting with difculty in opening the eyes on the rst day of life. On ocular examination multiple adhesional bands are found between lids in both the eyes. On systemic evaluation a smooth philtrum, low set ears suggesting Edward's syndrome was revealed in baby A and baby B had posterior cleft palate, dermal erosions along with mandibular dysplasia revealing ectodermal dysplasia cleft palate syndrome. Transection under local anesthesia was done on both the babies. Examination post transection revealed normal eyelid function. Ankyloblepharon Filiform Adnatum (AFA) in a neonate should alert the ophthalmologist because it can be rarely associated with life threatening multi-systemic defects. This case series aims to highlight such rare presentations and exemplies the need for multidisciplinary approach. Early surgical intervention performed can reduce the risk of occlusion induced amblyopia and also helps in the detailed ophthalmologic examination later in life.

scholarly journals Hemoperitoneum Secondary to Spontaneous Rupture of a Retroperitoneal Varix

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Derrick D. Eichele
Keyword(s):  
Abdominal Pain ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Acute Abdominal Pain ◽  
Early Recognition ◽  
Relevant Literature ◽  
Hypovolemic Shock ◽  
Rare Condition ◽  
Unique Case ◽  
Life Threatening

Hemoperitoneum due to a ruptured retroperitoneal varix is an exceedingly rare condition and a poor prognostic sign with catastrophic and life-threatening complication of portal hypertension. We present a unique case of a 56-year-old female with cirrhosis secondary to primary sclerosing cholangitis who presented with acute abdominal pain and hypovolemic shock prior to a cardiac arrest following a ruptured retroperitoneal varix without prior esophageal varices and a newly identified intrahepatic cholangiocarcinoma. The clinical presentation with abdominal pain and hemorrhagic shock is consistently reported in the relevant literature. Early recognition affords appropriate management and urgent surgical intervention leading to survival.

A suprasellar germ cell tumour presenting with cranial diabetes insipidus

2019 ◽  
Author(s):  
Suhaniya Samarasinghe ◽  
Rebecca Scott ◽  
Michael J Seckl ◽  
Mike Gonzalez ◽  
Richard Harvey ◽  
...  
Keyword(s):  
Germ Cell ◽  
Diabetes Insipidus ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Cranial Diabetes Insipidus

scholarly journals COVD-01. VINBLASTINE MONOTHERAPY INDUCTION FOR LOCALISED CNS GERMINOMA DURING THE COVID-19 PANDEMIC

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii282-iii282
Author(s):  
Rafael Moleron ◽  
Sara Stoneham ◽  
Thankamma Ajithkumar ◽  
Justin Cross ◽  
James Nicholson ◽  
...  
Keyword(s):  
Germ Cell ◽  
Treatment Options ◽  
Single Agent ◽  
Germ Cell Tumour ◽  
Research Priorities ◽  
Tumour Volume ◽  
Cell Tumour ◽  
Low Grade ◽  
Testicular Seminoma

Abstract INTRODUCTION Patients with localised CNS-germinoma have excellent survival. More recently, intensive inpatient chemotherapy (carboPEI=carboplatin/etoposide/ifosfamide in Europe) has been effectively employed to reduce radiotherapy fields and/or dose. Current research priorities focus on reducing treatment burden and long-term sequelae. Of note, outpatient-based single-agent carboplatin chemotherapy is associated with excellent outcomes in metastatic testicular seminoma (an identical pathology) [Alifrangis,EJC,2020]. Recently, successful vinblastine monotherapy was reported in localised CNS-germinoma [Murray,Neurooncol-Adv,2020]. METHODS Due to the COVID-19 pandemic, adapted UK guidelines for germ-cell-tumour management were distributed, including potential non-standard treatment options that would reduce hospital visits/admissions. A 30-year-old patient presented with a 32mmx30mmx35mm diameter solid+multi-cystic localised pineal CNS lesion, consistent radiologically with a germ-cell-tumour with prominent teratoma component. Investigation revealed negative AFP/HCG markers and biopsy-proven pure germinoma. After appropriate consent, the patient commenced 12-week induction with weekly vinblastine monotherapy (low-grade-glioma dosing [Lassaletta,JCO,2016]), with wk6&12 MRI re-assessment prior to definitive radiotherapy. RESULTS Vinblastine was well-tolerated. After initial 4mg/m2 test-dosing (wk1), standard 6mg/m2 was delivered for wk2, but resulted in asymptomatic neutropenia (nadir 0.3x10^9/l) and missed dosing at wk3. Subsequent doses were 4mg/m2, with no further neutropenia. As expected, MRI showed moderate 40% tumour volume reduction by wk12. Surgical resection of the residual presumed teratoma component was undertaken prior to radiotherapy. CONCLUSION Patients with CNS-germinoma have excellent outcomes and reduction of treatment-effects remains a priority. The exquisite chemosensitivity of germinoma, excellent results from monotherapy for metastatic testicular disease, and early promise of vinblastine monotherapy lend itself to further exploration for CNS-germinoma.

Sign in / Sign up

Export Citation Format

Share Document