Serial anterior segment optical coherence tomography post autologous simple limbal epithelial transplantation

2020 ◽  
Vol 13 (12) ◽  
pp. e236692
Author(s):  
Anahita Kate ◽  
Swapna S Shanbhag ◽  
Ritin Goyal ◽  
Sayan Basu

A 24-year-old young man presented to us with total limbal stem cell deficiency (LSCD) in the right eye 1 year post ocular chemical burn. The patient subsequently underwent limbal biopsy in the healthy contralateral eye and autologous simple limbal epithelial transplantation in the right eye. The patient was followed up with sequential imaging of the cornea with high-resolution anterior segment optical coherence tomography (HR-ASOCT) for 3 years. The serial HR-ASOCT imaging in the operated eye showed regeneration of the epithelium from the limbal transplant over the human amniotic membrane (hAM) with integration of the transplant within the cornea with subepithelial retention of the hAM. Over the long-term follow-up, thinning of the hAM and thickening of the epithelium was noted. At 3 years, the cornea maintained an intact epithelium with no signs of recurrence of LSCD.

2017 ◽  
Vol 8 (3) ◽  
pp. 459-464 ◽  
Author(s):  
Irini Chatziralli ◽  
George Theodossiadis ◽  
Dimitrios Brouzas ◽  
Ioannis Emfietzoglou ◽  
Panagiotis Theodossiadis

Purpose: We present the evolution of X-linked juvenile retinoschisis (XLRS) in a male patient using optical coherence tomography (OCT) with a long-term follow-up time of 15 years. Case Description: A 10-year-old male patient presented at the Medical Retina Department of our hospital complaining for blurred vision in both eyes. At the initial presentation in 2001, his best corrected visual acuity (BCVA) was 6/12 in both eyes on the Snellen chart. Based on clinical and OCT findings, the diagnosis of XLRS was made, and it was confirmed by genetic testing. No treatment was performed, but the patient was regularly examined. His BCVA and OCT findings remained relatively stable from 2001 to 2012, when BCVA decreased to 6/18 and 6/24 in the right and left eye, respectively. In 2016, his BCVA was 6/24 and 6/36 in right and left eye, respectively, while OCT depicted significant macular thinning, accompanied by irregularities of the foveal contour in both eyes. Conclusion: Patients with XLRS should be monitored regularly to evaluate the progression of the disease and manage the potential complications.


2016 ◽  
Vol 32 (6) ◽  
pp. 855-862 ◽  
Author(s):  
Tomasz Roleder ◽  
Mariusz Skowerski ◽  
Andrzej Wiecek ◽  
Marcin Adamczak ◽  
Beata Czerwienska ◽  
...  

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Tomasz Roleder ◽  
Mariusz Skowerski ◽  
Andrzej Wiecek ◽  
Marcin Adamczak ◽  
Beata Czerwienska ◽  
...  

Intoduction: Although radiofrequency renal denervation (RF-RND) may cause acute spasm, intimal injury and thrombus formation, there are no data on long-term renal artery (RA) healing. Hypothesis: Aim of this study was to assess the RA healing after RF-RND by optical coherence tomography (OCT) imaging and quantitative contrast angiography (QCA) at long-term follow-up. Methods: A single center registry enrolled 12 patients (22 RA) with refractory hypertension previously treated with RF-RND (Symplicity, Medtronic). Imaging studies (QCA and OCT) were done at (mean±SD) 18.41±5.83 months after RF-RND. Results: No adverse events or complications were noted during the follow-up. Ten patients (83%) achieved significant reductions of blood pressure by ≥10 mmHg on 4.50 ± 1.08 medications per patient. OCT analysis involved 518 mm of pullbacks and 518 cross-sections. There were 26 spots of focal intimal thickening found in 10 (83%) patients in 14 (64%) arteries and calcifications in 2 (9%) of treated RA. The mean area of focal intimal thickening was 0.054±0.033 mm2 and it was limited to the intimal layer. No vessel dissection, thrombus, intimal tear or acute vasospasms were observed during the OCT analysis. The QCA revealed that minimal lumen and proximal lumen diameter were smaller after the RND and this difference was persistent at follow-up, as compared to measurements obtained before RND [6.21±1.01 vs. 5.61 ± 0.60, p=0.005 and 5.53±0.99 vs. 5.15±0.67, p=0.034, respectively]. Conclusions: There is a favorable long-term vessel healing after RF-RND without significant RA stenosis. Only focal intimal thickening and a modest reduction of the minimal lumen diameter may be observed in long-term and their relation to the RND procedure needs further studies.


2008 ◽  
Vol 51 (9) ◽  
pp. 968-969 ◽  
Author(s):  
Masamichi Takano ◽  
Masanori Yamamoto ◽  
Shigenobu Inami ◽  
Daisuke Murakami ◽  
Koji Seimiya ◽  
...  

2013 ◽  
Vol 29 (5) ◽  
pp. 977-988 ◽  
Author(s):  
Rodolfo Staico ◽  
Marco A. Costa ◽  
Daniel Chamié ◽  
Hiram Bezerra ◽  
Luciana V. Armaganijan ◽  
...  

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