Central ossifying fibroma of mandible

2020 ◽  
Vol 13 (12) ◽  
pp. e239286
Author(s):  
Kumar Nilesh ◽  
Prashant Punde ◽  
Nitin Shivajirao Patil ◽  
Amol Gautam

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.

2019 ◽  
Vol 120 (6) ◽  
pp. 897-902 ◽  
Author(s):  
Lumarie Santiago ◽  
Beatriz E. Adrada ◽  
Abigail S. Caudle ◽  
Mark W. Clemens ◽  
Dalliah M. Black ◽  
...  

2017 ◽  
Vol 139 (3) ◽  
pp. 811e-812e ◽  
Author(s):  
Carolyn R. Rogers-Vizena ◽  
Peter Weinstock ◽  
Katie Livingston ◽  
Sanjay P. Prabhu

Author(s):  
Cheng-I Yen ◽  
Pang-Yun Chou ◽  
Angela Ting-Wei Hsu ◽  
Mark Shafarenko ◽  
Georgios Kolios ◽  
...  

2021 ◽  
Author(s):  
Tobias Butelmann ◽  
Hans Priks ◽  
Zoel Parent ◽  
Trevor G. Johnston ◽  
Tarmo Tamm ◽  
...  

AbstractThe three-dimensional printing of cells offers an attractive opportunity to design and develop innovative biotechnological applications, such as the fabrication of biosensors or modular bioreactors. Living materials (LMs) are cross-linked polymeric hydrogel matrices containing cells, and recently, one of the most deployed LMs consists of F127-bis-urethane methacrylate (F127-BUM). The material properties of F127-BUM allow reproducible 3D printing and stability of LMs in physiological environments. These materials are permissible for small molecules like glucose and ethanol. However, no information is available for oxygen, which is essential— for example, towards the development of aerobic bioprocesses using microbial cell factories. To address this challenge, we investigated the role of oxygen as a terminal electron acceptor in the budding yeast’s respiratory chain and determined its permissibility in LMs. We quantified the ability of cell-retaining LMs to utilize oxygen and compared it with cells in suspension culture. We found that the cells’ ability to consume oxygen was heavily impaired inside LMs, indicating that the metabolism mostly relied on fermentation instead of respiration. To demonstrate an application of these 3D printed LMs, we evaluated a comparative brewing process. The analysis showed a significantly higher (3.7%) ethanol production using 3D printed LMs than traditional brewing, indicating an efficient control of the metabolism. Towards molecular and systems biology studies using LMs, we developed a highly reliable method to isolate cells from LMs for flow cytometry and further purified macromolecules (proteins, RNA, and DNA). Our results show the application of F127-BUM-based LMs for microaerobic processes and envision the development of diverse bioprocesses using versatile LMs in the future.


2020 ◽  
Vol 194 ◽  
pp. 108940 ◽  
Author(s):  
Saeideh Kholgh Eshkalak ◽  
Erfan Rezvani Ghomi ◽  
Yunqian Dai ◽  
Deepak Choudhury ◽  
Seeram Ramakrishna

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