A Solitary Rosai-Dorfman Disease of The Talus: The First Case Report of Bisphosphonate Therapy with Imaging Follow-up

Rosai-Dorfman disease (RDD) manifesting as a solitary osseous lesion especially of talus bone is rare. The authors reported a 31-year-old Thai man who had chronic left ankle pain and the biopsy of his talar lesion demonstrated emperipolesis, the typical histological feature of RDD. He was treated with curettage and adjuvant bisphosphonate and appeared to show improvement in clinical symptoms and radiological evidence. To the authors’ knowledge, this is the first report of an intraosseous RDD lesion treated with bisphosphonate with imaging follow-up. Keywords: Rosai-Dorfman disease; Talus; Solitary; Radiology; Bisphosphonate

A path less travelled — Short review on ossifying fibroma and osseous dysplasia

Fibro-osseous lesions (FOL) are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product. The mineralized product may be ossification (sometimes cementum formation) or calcification of fibrous tissue by metaplasia. These lesions have similar radiographic and histopathologic features hence the term fibre- osseous lesion is not a diagnosis, rather a description of the presence of fibrous and calcified tissue. They may be developmental (fibrous dysplasia), reactive (cemento-osseous dysplasia) or neoplastic (ossifying/cementifying fibroma). This article presents the commonly used classification for fibro-osseous lesions and an insight into a few changes that have been introduced in the recent past with emphasis on Ossifying Fibroma and Osseous Dysplasia.Ossifying fibromas are considered as benign fibro-osseous neoplasms which are principally encountered within the jawbones. Cemento-osseous dysplasias are non-neoplastic fibro- osseous lesion. Since 1971, the World Health Organization classified cemental lesions into 4 distinct entities, as follows: Periapical Cemental Dysplasia, Benign Cementoblastoma (true cementoma), Cementifying Fibroma and Gigantiform Cementoma (GC). The term, gigantiform cementoma, may imply a solitary process but it is misleading because the condition typically presents as slow-growing, multifocal/multiquadrant and expansile lesions involving both jaws. WHO classified it in Osseous dysplasia and El-Mofty et al. under Ossifying fibroma.

Desmoplastic ameloblastoma in maxilla mimicking fibro-osseous leison: A case report

Desmoplastic Ameloblastoma accounts for 4% to 13% of all ameloblastomas and is a rare variant with high rate of recurrence. The desmoplastic variant of ameloblastoma usually appears in the anterior and premolar regions and sometimes resembles a benign fibro-osseous lesion showing a mixed radiolucent and radiopacity in the radiographic examination. Malignant transformation with repeated postsurgical recurrences have also been reported. In this paper we present a case of a 22-year-old female with swelling in the left upper jaw which turned out to be desmoplastic ameloblastoma. The pathologist and the clinician should be aware of the concepts and the association with malignant transformation and spread of the lesion in order to deliver appropriate treatment and to avoid further recurrences of the leison.

Cherubism: Case Report and Review of Literature

Cherubism is an autosomal dominant, very rare benign fibro-osseous lesion, with an estimation of only 300 cases have been reported worldwide. Cherubism is characterized clinically by bilateral symmetrical self-limiting jaw enlargement starts in the childhood or early teens.Mandible is mostly affected although maxilla and zygomatic bones may be involved but to a lower extent), and is associated with tooth displacement and severe malocclusion. Histopathologically, it is indistinguishable from giant cell lesions therefore the clinical manifestations of the disease remain the Gold Stone. Keywords: Cherubism, mandible, maxilla, bilateral palatal swelling

Juvenile psammomatoid ossifying fibroma of the parietal bone and review of calvarial presentations: illustrative case

BACKGROUND Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign fibro-osseous lesion that only rarely presents in the calvaria. OBSERVATIONS The authors reported a case of JPOF in the left parietal bone of a 20-year-old patient and reviewed the 27 other cases of JPOF occurring in the calvaria as reported in the literature. LESSONS JPOF rarely presents in the calvaria, and because diagnosis is a histopathologic one, clinicians should consider this entity when presented with a lytic, expansile mass on imaging. Little is known about the molecular mechanisms driving development of JPOF. MDM2 amplification may play a role, although this was not seen in the case presented herein.

The importance of cone-beam computed tomography for the diagnosis and treatment plan of florid cemento-osseous dysplasia: a case report

Cone-beam computed tomography (CBCT) provides images without overlapping anatomical structures, which is important for the diagnosis and assessment of florid cemento-osseous dysplasia. This fibro-osseous lesion that affects the alveolar process without compromising the teeth’ pulp vitality is usually asymptomatic, and bone expansion, cortical disruption, and root resorption are uncommon. Due to its avascular characteristic, surgical procedures are often contraindicated. In this case, a 59-year-old female patient presented with a complaint of pain in the right maxillary central incisor. Panoramic and periapical radiographs showed florid cemento-osseous dysplasia in some regions. The right maxillary central incisor showed an extensive radiolucent image suggestive of root resorption but without fibro- -osseous lesion. For better evaluation and implant planning, CBCT was performed and demonstrated florid cemento-osseous dysplasia adjacent to the right maxillary central incisor, contraindicating implant placement. In other regions, CBCT enabled the identification of the expansive features of this fibro-osseous lesion.