scholarly journals Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

2018 ◽  
Vol 103 (8) ◽  
pp. 1024-1029 ◽  
Author(s):  
Ryan J Diel ◽  
Jodi Hwang ◽  
Zachary A Kroeger ◽  
Roy C Levitt ◽  
Constantine D Sarantopoulos ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Chronic Migraine ◽  
Dry Eye ◽  
Botulinum Toxin A ◽  
Demographic Data ◽  
Tear Film ◽  
Phenol Red ◽  
Toxin A ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

BackgroundTo evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients.MethodsRetrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review. Standardised validated surveys were administered to assess symptoms prior to and after BoNT-A injection. Preinjection tear volumes were obtained using the phenol red thread (PRT) test.ResultsPreinjection migraine, photophobia and dry eye symptom scores were all significantly correlated, p<0.05, and none were associated with preinjection PRT results. After BoNT-A, improvements in migraine, photophobia and dry eye symptoms were also significantly correlated, p<0.05 and similarly did not associate with preinjection PRT results. Photophobia scores significantly improved following BoNT-A, while dry eye symptoms significantly improved in those with severe symptoms at baseline (DEQ-5 score ≥12), p=0.027. In logistic regression analysis of all individuals with dry eye symptoms (DEQ-5 ≥6), individuals with more severe dry eye symptoms were more likely improve, OR 1.27, 95% CI 1.06 to 1.51, p<0.01.ConclusionsBoNT-A significantly improved photophobia in patients being treated for migraine and also improved dry eye symptoms in patients with severe symptoms at baseline, independent of baseline tear film volume. These improvements may be due to modulation of shared trigeminal neural pathways.

scholarly journals Comparable effects on tear film parameters after femtosecond laser-assisted and conventional cataract surgery

2020 ◽  
Vol 40 (11) ◽  
pp. 3097-3104 ◽  
Author(s):  
Marc Schargus ◽  
Svetlana Ivanova ◽  
Gesa Stute ◽  
H. Burkhard Dick ◽  
Stephanie C. Joachim
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Surgical Techniques ◽  
Tear Film ◽  
Schirmer Test ◽  
Fluorescein Staining ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Abstract Purpose Dry eye symptoms after conventional cataract surgery are a very common problem. Until now, only few data are available on objective tear film parameters in regard to femtosecond laser-assisted cataract surgery (LCS). Aim of this study was therefore to analyze and compare tear film parameter changes between LCS and conventional cataract surgery. Methods A consecutive group of 34 patients, scheduled for cataract surgery, were randomly selected for either LCS or conventional cataract surgery (17 patients/group). Tear film assessments including tear film osmolarity, Schirmer test, MMP-9 analysis via quantitative ELISA, corneal sensitivity, corneal fluorescein staining, and conjunctival fluorescein staining were sequentially evaluated pre- as well as 1 and 3 months postoperatively. Results Both groups showed no significant difference in baseline characteristics. All surgeries were performed without any complications. After 1 and 3 months, there was no statistically significant difference in regard to tear film osmolarity (1 month: p = 0.81, 3 months: p = 1.0), Schirmer test (1 month: p = 0.35, 3 month: p = 0.08), and MMP-9 concentration (1 month: p = 0.36, 3 month: p = 0.28) between the two groups. Conclusions Neither LCS nor conventional cataract surgery affected objective tear film parameters significantly during our 3-month postoperative observation period. Hence, both surgical techniques can be equally used to treat patients without prior dry eye symptoms.

Associations between dry eye symptoms with tear film stability, volume, and osmolarity in a sample of young adults in Kuala Lumpur

2018 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Bariah Mohd-Ali ◽  
MohamadHanif Hajar-Maidin ◽  
Asmah Ahmad ◽  
Zainora Mohammed ◽  
Jamaluddin Mohamed
Keyword(s):  
Young Adults ◽  
Dry Eye ◽  
Tear Film ◽  
Kuala Lumpur ◽  
Film Stability ◽  
Tear Film Stability ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

scholarly journals Acute withdrawal and botulinum toxin A in chronic migraine with medication overuse: a double-blind randomized controlled trial

Brain ◽  
2019 ◽  
Vol 142 (5) ◽  
pp. 1203-1214 ◽  
Author(s):  
Judith A Pijpers ◽  
Dennis A Kies ◽  
Mark A Louter ◽  
Erik W van Zwet ◽  
Michel D Ferrari ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Botulinum Toxin ◽  
Chronic Migraine ◽  
Medication Overuse ◽  
Botulinum Toxin A ◽  
Controlled Trial ◽  
Toxin A ◽  
Double Blind ◽  
Acute Withdrawal ◽  
Randomized Controlled

scholarly journals Botulinum Toxin A for the Treatment of Photophobia and Dry Eye

Ophthalmology ◽  
2018 ◽  
Vol 125 (1) ◽  
pp. 139-140 ◽  
Author(s):  
Ryan J. Diel ◽  
Zachary A. Kroeger ◽  
Roy C. Levitt ◽  
Constantine Sarantopoulos ◽  
Heather Sered ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Dry Eye ◽  
Botulinum Toxin A ◽  
Toxin A

Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters

2015 ◽  
Vol 99 (8) ◽  
pp. 1126-1129 ◽  
Author(s):  
Anat Galor ◽  
Elizabeth R Felix ◽  
William Feuer ◽  
Nabeel Shalabi ◽  
Eden R Martin ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

scholarly journals Effectiveness of eye-light therapy in improving dry eye symptoms

2021 ◽  
Vol 7 (3) ◽  
pp. 509-514
Author(s):  
Onkar H Pirdankar ◽  
Vaishal P Kenia ◽  
Merlin Saldanha ◽  
Raj V Kenia
Keyword(s):  
Layer Thickness ◽  
Dry Eye ◽  
Environmental Changes ◽  
Tear Film ◽  
Light Therapy ◽  
Lipid Layer ◽  
Eye Symptoms ◽  
Upper Lid ◽  
Post Therapy ◽  
Dry Eye Symptoms

: We aimed to examine the effectiveness of eye-light therapy in improving the dry eye symptoms.: The retrospective case series where patients who underwent eye-light therapy between March 2019 to May 2020 were analyzed. Twenty patients aged ≥18 years with dry eyes were included. Patients with ocular infections, complications, contact lens users and missing data were excluded. OSDI scores and tear parameters such as  noninvasive break up time (NIBUT), lipid layer thickness (LLT), tear meniscus height, meibography of upper and lower lid were evaluated pre and post one month Eye-Light therapy.: Twenty patients with mean±SD age of 43.55±20.53 years and mean spherical equivalent refractive error of 0.69±1.79 diopters were analyzed. OSDI was significantly associated with NBUT (r=-0.50, P = 0.02), lipid layer thickness (r=-0.45, P=0.047) and tear height (r =-0.45, P=0.046).  OSDI was positively associated with upper lid meibography (r=0.74, P=&#60;0.001) and lower lid meibography (r=0.45, P=0.045). Post-therapy, reduction in OSDI score post-therapy was present, NBUT was similar, lipid layer thickness and tear height were increased, meibography of upper lid was reduced, and meibography of lower lid did not alter much. Eye-light therapy is effective in reducing dry eye related symptoms with minimal immediate effect on tear film parameters post therapy. Eye-light therapy acts as an adjunct to ameliorate MGD. MGD being a chronic disease requires sustained therapy with environmental changes. Long term evaluation is required to assess the tear film changes and the pattern of efficacy of light therapy.

scholarly journals In Vivo Confocal Microscopic Evaluation of Corneal Langerhans Cells in Dry Eye Patients§

2014 ◽  
Vol 8 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Federica Machetta ◽  
Antonio M Fea ◽  
Alessandro G Actis ◽  
Ugo de Sanctis ◽  
Paola Dalmasso ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Surface Damage ◽  
Nerve Plexus ◽  
Sjogren Syndrome ◽  
Central Cornea ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Purpose. To assess inflammatory involvement of cornea in dry eye by means of confocal microscopy, evaluating the presence and distribution of Langherans cells (LCs). Methods: 98 eyes of 49 subjects were enrolled: 18 subjects affected by Sjögren Syndrome Dry Eye (SSDE), 17 with Non-Sjögren Syndrome Dry Eye (NSSDE), 14 healthy volunteeers. Dry eye symptoms, tear film, ocular surface damage and corneal confocal microscopy were analized. Results: A significant increase of LCs density was observed at sub-basal nerve plexus (SSDE = 79 cells/mm2 and NDE = 22 cells/mm2; p = 0,0031) and sub-epithelial nerve plexus (SSDE = 38 cells/mm2 and NDE = 3 cells/mm2; p = 0,0169) in central cornea of SSDE group. An increased number of LCs from the center to the periphery of the cornea was observed, significant only in healthy volunteers group. In dry eye patients there was an increase in LCs density in both peripheral and central cornea with a significant difference between NDE (14,66 cells/mm2) and SSDE (56,66 cells/mm2) only in central cornea (p = 0,0028). In SSDE group, mean density of LCs in central cornea results also superior to NSSDE group (29,33 cells/mm2). There was no correlation between LCs density and dry eye symptoms, tear film deficiency and ocular surface damage. Conclusion: This study demonstrates the activation of an inflammatory and immunological reaction in cornea of NSSDE and SSDE patients. Confocal microscopy can be an important diagnostic tool in evaluation and follow-up of dry eye disease.

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