Wide-field optical coherence tomography deviation map for early glaucoma detection

Background/aimsThis study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).MethodsFour hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT (DRI-OCT Triton; Topcon, Tokyo, Japan). The individual wide-field scan was converted into a uniform template using the fovea and optic disc centres as fixed landmarks. Subsequently, the wide-field deviation map was obtained via the comparison between individual wide-field data and a normative wide-field database that had been created by combining images of healthy eyes into a uniform template in a previous study. The ability of the new wide-field deviation map to distinguish between EG and healthy eyes was assessed by comparing it with conventional deviation maps based on the area under the receiver operating characteristic curve (AUC).ResultsThe wide-field deviation map obtained using the normative wide-field database showed the highest diagnostic ability for the diagnosis of EG (AUC=0.980 and 961 for colour-coded pixels presenting <5% and <1%, respectively) among various deviation maps. Its AUC was significantly superior to that of most conventional deviation maps (p<0.05). The wide-field deviation map demonstrated early structural glaucomatous damage well over a wider area.ConclusionThe wide-field SS-OCT deviation map exhibited good performance for distinguishing between eyes with EG and healthy eyes. The visualisation of the wider damaged area on the wide-field deviation map could be useful for the diagnosis of EG in clinical settings.

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Diagnostic Ability of Wide-field Retinal Nerve Fiber Layer Maps Using Swept-Source Optical Coherence Tomography for Detection of Preperimetric and Early Perimetric Glaucoma

Journal of Glaucoma ◽

10.1097/ijg.0000000000000662 ◽

2017 ◽

Vol 26 (6) ◽

pp. 577-585 ◽

Cited By ~ 16

Author(s):

Won June Lee ◽

Kyeong Ik Na ◽

Young Kook Kim ◽

Jin Wook Jeoung ◽

Ki Ho Park

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Wide Field ◽

Optical Coherence ◽

Fiber Layer ◽

Diagnostic Ability ◽

Swept Source ◽

Nerve Fiber Layer ◽

Retinal Nerve Fiber

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Wide-Field Swept-Source Optical Coherence Tomography Analysis of Interocular Symmetry of Choroidal Thickness in Healthy Young Individuals

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.62.3.5 ◽

2021 ◽

Vol 62 (3) ◽

pp. 5

Author(s):

Min-Su Kim ◽

Hyung-Bin Lim ◽

Woo-Hyuk Lee ◽

Kyeung-Min Kim ◽

Ki Yup Nam ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Thickness ◽

Wide Field ◽

Optical Coherence ◽

Swept Source ◽

Tomography Analysis

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Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography

PLoS ONE ◽

10.1371/journal.pone.0125957 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125957 ◽

Cited By ~ 33

Author(s):

Zhiyong Yang ◽

Andrew J. Tatham ◽

Robert N. Weinreb ◽

Felipe A. Medeiros ◽

Ting Liu ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Ganglion Cell ◽

Plexiform Layer ◽

Spectral Domain ◽

Inner Plexiform Layer ◽

Optical Coherence ◽

Diagnostic Ability ◽

Swept Source

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Topographic Analysis of Short Posterior Ciliary Arteries Using Wide-Field Swept-Source En-Face Optical Coherence Tomography

10.21203/rs.3.rs-151008/v1 ◽

2021 ◽

Author(s):

Raphael Lejoyeux ◽

Raphael Atia ◽

Kiran Vupparaboina ◽

Mohamed Ibrahim ◽

Jose-Alain Sahel ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Posterior Pole ◽

Wide Field ◽

Temporal Part ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Topographic Analysis ◽

En Face ◽

Ciliary Arteries

Abstract Purpose: To study the topographic distribution of the short posterior ciliary arteries (SPCA) entry sites into the choroid in normal eyes using structural en-face swept source optical coherence tomography (SS-OCT). Methods: Retrospective analysis of SS-OCT scans (wide-field structural SS-OCT 12x12mm) of 13 healthy subjects was performed. Cross-sectional swept-source OCT scans derived from a volume scan were represented as en-face image display following the Choroid-Scleral Interface to obtain en-face OCT. SPCAs in their last scleral location before choroidal entrance were identified manually, counted and localized by two masked observers. Correlations between two masked observers were analyzed using inter- and intra- class correlation. Results: Accuracy for the choroidal inner and outer border segmentation was 95-99%. Eighteen eyes from 13 normal subjects were included for SPCA analysis. The mean number of arteries was 13.8±3.5 per eye. Thirty-six percent were in the center of the posterior pole image; however, 21% were in the temporal part of the posterior pole. Median accuracy of the detection is 0.94. The correlation between the two observers was fair (0.54).Conclusion: Our algorithm allows visualization of the SPCA at the posterior pole of the eye using wide-field en-face SS-OCT. It can also help the clinicians to study the SPCAs in numerous ocular diseases, particularly its relationship with focal choroidal diseases.

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Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-311942 ◽

2018 ◽

Vol 103 (2) ◽

pp. 216-221 ◽

Cited By ~ 35

Author(s):

Takao Hirano ◽

Jyunya Kitahara ◽

Yuichi Toriyama ◽

Hirotsugu Kasamatsu ◽

Toshinori Murata ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Characteristic Curve ◽

Vascular Density ◽

Optical Coherence ◽

Image Size ◽

Healthy Individuals ◽

Cross Sectional ◽

Swept Source ◽

Retinal Microvasculature

AimsTo evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes.MethodsNon-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed. The area under the receiver operating characteristic curve was estimated to assess the ability of each image size to predict DR.ResultsThis prospective, cross-sectional study included 60 eyes, (non-DR, 13 eyes; non-proliferative DR (NPDR), 24 eyes; proliferative DR (PDR), 23 eyes) of 46 patients with diabetes and 21 eyes of 16 healthy individuals. In the 12×12 mm images, the PD of healthy individuals was significantly greater than that of patients with NPDR or PDR for all layers (NPDR, p<0.05; PDR, p<0.001 0.001; FD, p<0.001) or PDR (VLD, p<0.001; FD, p<0.001 for all layers). The results were similar for the 3×3 mm and 6×6 mm images. Overall, PD, VLD and FD progressively decreased with worsening DR severity in segmented and non-segmented layers for all SS-OCTA scan sizes. For detecting DR, 3×3 mm images best predicted DR for all evaluated quantitative parameters.ConclusionsVascular changes in DR can be monitored in detail through quantitative evaluations that combine different SS-OCTA scan sizes and parameters.

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